A5005124809- Genetics, Aging, and Longevity in Model Organisms
- Telomeres, Telomerase, and Senescence
- Obesity, Physical Activity, Diet
- DNA Repair Mechanisms
- Nutritional Studies and Diet
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Health and Lifestyle Studies
- Birth, Development, and Health
- Carcinogens and Genotoxicity Assessment
- Fatty Acid Research and Health
- Circadian rhythm and melatonin
- Cardiac Ischemia and Reperfusion
- Skin Protection and Aging
- NF-κB Signaling Pathways
- Air Quality and Health Impacts
- Reproductive Biology and Fertility
- Science, Research, and Medicine
- Antioxidant Activity and Oxidative Stress
- Dietary Effects on Health
- Genomics, phytochemicals, and oxidative stress
- Growth Hormone and Insulin-like Growth Factors
- Consumer Attitudes and Food Labeling
- Muscle Physiology and Disorders
- Pluripotent Stem Cells Research
University of Bologna
2016-2025
Istituto Nazionale Biostrutture e Biosistemi
2023-2025
Drexel University
2009-2013
Lankenau Institute for Medical Research
2001-2006
University of Pisa
1999
Abstract Aging is a major risk factor for the majority of human diseases, and development interventions to reduce intrinsic rate aging expected age-related diseases including cardiovascular disease, cancer, dementia. In skin, manifests itself in photodamage dermal atrophy, with underlying tissue reduction impaired barrier function. To determine whether rapamycin, an FDA-approved drug targeting mechanistic target rapamycin (mTOR) complex, can senescence markers exploratory,...
Electronic cigarettes (e-cigs) are devices designed to deliver nicotine in a vaping solution rather than smoke and without tobacco combustion. Perceived as safer alternative conventional cigarettes, e-cigs aggressively marketed lifestyle-choice consumables, thanks few restrictions lack of regulatory guidelines. E-cigs have also gained popularity among never-smokers teenagers, becoming an emergent public health issue. Despite the burgeoning worldwide consumption e-cigs, their safety remains...
A reduction in IGF-I signaling has been found to increase lifespan multiple organisms despite the fact that is a trophic factor for many cell types and have protective effects against forms of damage acute settings. The longevity seen response reduced suggests there may be differences between chronic impact signaling. We examined possibility long-term stimulation with negative at cellular level using quiescent human fibroblasts. find fibroblast cells exposed 14 days viability as judged by...
Agricultural food waste and by-products could provide high-value compounds that positively affect human environmental health, thus representing promising ingredients for cosmeceutical products. This study explores the biological activities of tomato skin (HP) pomegranate peel (PPE) extracts on oral mucosa to evaluate their possible use in mouthwashes. The mouthwash (MW) containing them were evaluated Human Primary Gingival Epithelial cells (HGECs). antioxidant anti-inflammatory analyzed...
Ischemic preconditioning is a complex cardioprotective phenomenon that involves adaptive changes in cells and molecules occurs biphasic pattern: an early phase after 1-2 h late 12-24 h. While it widely accepted reactive oxygen species are strongly involved triggering ischemic preconditiong, not clear if they play major role the or of which mechanisms involved. The present study was designed to investigate behind H(2)O(2)-induced cardioprotection rat neonatal cardiomyocytes. We focused on...
Normal somatic cells have a limited replicative lifespan, and serial subcultivation ultimately results in senescence. Senescent are irreversibly growth-arrested show impaired responses to mitogens. Activation of the ERK signaling pathway, an absolute requirement for cell proliferation, nuclear relocalization active ERKs, event senescent fibroblasts. This impairment coincides with increased activity phosphatase MKP2. Here we that lifespan can be altered by changes activity. Ectopic expression...
Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase span. However, data are conflicting and complicated by physiology neuroendocrine system. We have performed life-span analysis mice homozygous for an insertion Igf1 gene. These produce reduced display a phenotype consistent with significant decrease IGF-1. Life-span was carried out at three...
Abstract A large number of basic researches and observational studies suggested the cancer preventive activity vitamin E, but large-scale human intervention trials have yielded disappointing results actually showed a higher incidence prostate although mechanisms underlying increased risk remain largely unknown. Here we show through in vitro vivo that E produces marked inductive effect on carcinogen-bioactivating enzymes pro-oxidant status promoting both DNA damage cell transformation...
Recently, the Food and Drug Administration authorized marketing of IQOS Tobacco Heating System as a Modified Risk Product based on an electronic heat-not-burn technology that purports to reduce risk.
Amniotic fluid stem cells (AFSCs) are characterized in vivo by a unique niche guarantying their homeostatic role the body. Maintaining functionality of ex for clinical applications requires continuous improvement cell culture conditions. Cellular redox status plays an important biology as long reactive oxygen species (ROS) concentration is finely regulated and adverse effects excluded. The aim this study was to investigate protective effect two antioxidants, sulforaphane (SF)...
In order to examine potential differences in genomic stability, we have challenged fibroblasts derived from five different mammalian species of variable longevity with the genotoxic agents, etoposide and neocarzinostatin. We report that cells longer-lived exhibit more tumor protein p53 binding 1 (53BP1) foci for a given degree DNA damage relative shorter-lived species. The presence greater number 53BP1 was associated decreased fragmentation lower percentage exhibiting micronuclei. These data...
Healthy eating and active lifestyle habits are essential for a child's development, wellbeing, health. School setting family environment play crucial role in shaping these this could be reflected different behavior patterns during weekdays weekends.We investigated primary school children's through cross-sectional analysis of 428 Italian children, with mean age 8.99 years (±1.43). Data were collected from May to June 2017 using weekly diary assess lifestyles.Children who eat their morning...
The Peto's paradox consists in the observation that individuals from long-lived and large animal species do not experience a higher cancer incidence, despite being exposed for longer time to possibility of accumulating mutations having more target cells phenomenon. existence this has been recently confirmed (Vincze et al., 2022). Concurrently, robust evidence published longevity involves convergent evolution cellular mechanisms prevent accumulation (Cagan It remains unclear which are...