A5071024866- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Medical Imaging Techniques and Applications
- Cancer Cells and Metastasis
- Prostate Cancer Treatment and Research
- Estrogen and related hormone effects
- Gene expression and cancer classification
- HER2/EGFR in Cancer Research
- AI in cancer detection
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- Redox biology and oxidative stress
- Ionosphere and magnetosphere dynamics
- Chronic Lymphocytic Leukemia Research
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Genomics and Chromatin Dynamics
- Immunotherapy and Immune Responses
University of Nottingham
2015-2025
Nottingham University Hospitals NHS Trust
2010-2024
KIIT University
2024
Queen's Medical Centre
2019-2024
Manipal University Jaipur
2024
National Health Service
2023
Wellcome Trust
2023
St James's University Hospital
2023
Indian Institute of Engineering Science and Technology, Shibpur
2020-2022
Nottingham Biomedical Research Centre
2022
FEN1 has key roles in Okazaki fragment maturation during replication, long patch base excision repair, rescue of stalled replication forks, maintenance telomere stability and apoptosis. may be dysregulated breast ovarian cancers have clinicopathological significance patients. We comprehensively investigated mRNA expression multiple cohorts cancer [training set (128), test (249), external validation (1952)]. protein was evaluated 568 oestrogen receptor (ER) negative cancers, 894 ER positive...
Evaluating expression of the human epidermal growth factor receptor 2 (HER2) by visual examination immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part diagnostic assessment BCa due to its recognized importance as predictive and prognostic marker in clinical practice. However, scoring HER2 subjective, consequently prone interobserver variability. Given therapeutic implications scoring, more objective method required. In this paper, we report recent automated contest, held...
Abstract Purpose: Colorectal cancer is one of the most common cancers. The tumor necrosis factor–related apoptosis inducing ligand (TRAIL) pathway transmits apoptotic signals and anticancer agents that activate this system, which are in clinical development. We sought to determine prognostic value clinically relevant members colorectal patients. Experimental Design: used an arrayed panel tissue assess protein expression functional TRAIL receptors (TRAIL-R1 TRAIL-R2) both long short forms...
Aims Tumour‐infiltrating lymphocytes ( TIL s) are an important component of the immune response to cancer and have a prognostic value in breast cancer. Although several studies investigated role T cancer, B ‐Bs) ductal carcinoma situ DCIS ) remains uncertain. This study aimed assess ‐Bs . Methods results Eighty cases (36 pure 44 mixed with invasive cancer) were stained immunohistochemically for lineage markers CD 19, 20 plasma cell marker 138. density localization assessed, including...
The integration of genomic and transcriptomic profiles 2000 breast tumours from the METABRIC [Molecular Taxonomy Breast Cancer International Consortium] cohort revealed ten subtypes, termed integrative clusters (IntClust/s), characterised by distinct drivers. Central histopathology (
Image segmentation is a fundamental task in the field of imaging and vision. Supervised deep learning for has achieved unparalleled success when sufficient training data with annotated labels are available. However, annotation known to be expensive obtain, especially histopathology images where target regions usually high morphology variations irregular shapes. Thus, weakly supervised sparse annotations points promising reduce workload. In this work, we propose contrast-based variational...
AW464 (NSC 706704) is a novel benzothiazole substituted quinol compound active against colon, renal and certain breast cancer cell lines. NCI COMPARE analysis indicates possible interaction with thioredoxin/thioredoxin reductase, which upregulated under hypoxia. Through activity on HIF1alpha, VEGF levels are regulated angiogenesis controlled. A thioredoxin inhibitor could therefore exhibit enhanced hypoxic toxicity indirect antiangiogenic effects. In vitro experiments were performed...
Loss of HLA class I is important in ovarian cancer prognosis but its role as a prognostic indicator relation to therapy remains unproven. We studied the potential this antigen and significance platinum therapy. A total 157 primary cancers were assessed for immunohistochemically linked comprehensive database clinicopathological variables, treatment details, sensitivity. Tumours expressing high levels had significantly improved survival (P=0.044). There was 19-month difference median overall...
This study was aimed to develop a new method for personalising chemotherapeutic and granulocyte colony-stimulating factor (G-CSF) combined schedules, use it suggesting efficacious chemotherapy with reduced neutropenia. Clinical data from 38 docetaxel (Doc)-treated metastatic breast cancer patients were employed validating pharmacokinetic/pharmacodynamics model Doc, mathematical granulopoiesis. An optimisation procedure constructed used selecting improved treatment schedules. The accurately...
The molecular landscape of breast cancer (BC), especially the Luminal A subtype, remains to be fully delineated. Transcriptomic data show that tumours are enriched for aberrant expression genes in cell division control 42 homolog (CDC42) pathway. This study aims investigate protein CDC42 BC and assess its clinicopathological significance. Expression was examined by immunohistochemistry on tissue microarrays a well-characterised cohort 895 early-stage (I–IIIa) primary invasive BCs. observed...
Little is known about the role of microRNAs (miRNAs) in rewiring metabolism within tumours and adjacent non-tumour bearing normal tissue their potential cancer therapy. This study aimed to investigate relationship between deregulated miRNAs metabolic components murine duodenal polyps non-polyp-derived organoids (mPOs mNPOs) from a double-mutant ApcMinFbxw7∆G mouse model intestinal/colorectal (CRC). We analysed expression 373 12 genes mPOs mNPOs. Our findings revealed miR-135b might target...
This study aimed to identify predictors of response anthracycline-based chemotherapy (5-fluoro-uracil, epirubicin, cyclophosphamide (FEC)) in locally advanced primary breast cancer (LAPC). A total 91 LAPC patients were treated with six cycles FEC before surgery. Protein expression nine biomarkers (topoisomerase2α (Topo2α), ER, PR, HER2, Ki67, p53, EGFR, CK5/6 and CK14) was assessed pre-chemotherapy core biopsies using immunohistochemistry (IHC) results correlated clinical pathological...
Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and therapeutic resistance. However, the antibiotics antibacterial drugs signalling that regulate potency of anticancer treatment upon forced differentiation stem-like cell (CSC) are not fully defined yet. We screened an NIH-clinical collection small-molecule compound library antibacterial/anti-inflammatory agents identified potential candidate targeting CRC-SC for differentiation. Selected compounds were...
PMX464 is a novel benzothiazole substituted cyclohexadienone reportedly targeting the thioredoxin (Trx1)/thioredoxin reductase (TrxR1) system. We have previously shown that has enhanced hypoxic anti-proliferative effects in colorectal tumour cells, with some non-tumour cells (quiescent endothelium and fibroblasts) being relatively resistant. The current study aimed to validate Trx1 system as molecular target of investigate differential sensitivities normal at level.Proliferation, clonogenic...