A5005784207- Cancer Immunotherapy and Biomarkers
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Mitochondrial Function and Pathology
- Radiopharmaceutical Chemistry and Applications
- Autophagy in Disease and Therapy
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Galectins and Cancer Biology
- Pancreatic and Hepatic Oncology Research
- Eosinophilic Esophagitis
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Glioma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2018-2025
Ospedale Cannizzaro
2025
University of Messina
2023
University of Naples Federico II
2022-2023
University of Campania "Luigi Vanvitelli"
2022-2023
Tumori Foundation
2022
Cancer Institute (WIA)
2021
Ospedale Civile di Giaveno
2014
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2014
Istituti di Ricovero e Cura a Carattere Scientifico
2014
Background Colorectal cancer (CRC) is one of the most prevalent and deadly tumors worldwide. The majority CRC resistant to anti-programmed cell death-1 (PD-1)-based immunotherapy, with approximately 15% high-microsatellite instability, high tumor mutation burden, intratumoral lymphocytic infiltration. Programmed death-ligand 1 (PD-L1)/PD-1 signaling was described in solid cells. In melanoma, liver, thyroid cells, intrinsic PD-1 activates oncogenic functions, while lung it has a suppressor...
Abstract Cisplatin (CDDP) is commonly used to treat a multitude of tumors including sarcomas, ovarian and cervical cancers. Despite recent investigations allowed improve chemotherapy effectiveness, the molecular mechanisms underlying development CDDP resistance remain major goal in cancer research. Here, we show that mitochondrial morphology autophagy are altered different resistant cell lines. In osteosarcoma carcinoma, mitochondria fragmented closely juxtaposed endoplasmic reticulum; rates...
Immune checkpoint inhibitors cause side effects ranging from autoimmune endocrine disorders to severe cardiotoxicity. Periodic Fasting mimicking diet (FMD) cycles are emerging as promising enhancers of a wide range cancer therapies including immunotherapy. Here, either FMD alone or in combination with anti-OX40/anti-PD-L1 much more effective than immune delaying melanoma growth mice. also show trend for increased against lung model. As importantly, the cardiac fibrosis, necrosis and...
The use of Vascular Endothelial Growth Factor inhibitors (VEGFi) has become prevalent in the field medicine, given high incidence various pathological conditions necessitating VEGF inhibition within general population. These encompass a range advanced neoplasms, such as colorectal cancer, non-small cell lung renal ovarian and others, along with ocular diseases. utilization VEGFi is not without potential risks adverse effects, requiring healthcare providers to be well-prepared for...
Immune checkpoint inhibitors (ICIs) have significantly changed the oncology clinic in recent years, improving survival expectations cancer patients. ICI therapy a broad spectrum of side effects from endocrinopathies to cardiovascular diseases. In this study, pro-inflammatory and pro-fibrotic short-term ICIs preclinical models were analyzed.Firstly, human vitro model, cardiomyocytes co-cultured with hPBMC exposed (with CTLA-4 or PD-1 blocking agents, at 200 nM) for 72 h. After treatment,...
Abstract Background and Aims Cholangiocarcinoma (CCA), a rare aggressive hepatobiliary malignancy, presents significant clinical management challenges. Despite rising incidence evolving treatment options, prognosis remains poor, motivating the exploration of real‐world data for enhanced understanding patient care. Methods This multicenter study analyzed from 120 metastatic CCA patients at three institutions 2016 to 2023. Kaplan–Meier curves assessed overall survival (OS), while univariate...
Clonal myeloproliferation and fibrotic transformation of the bone marrow (BM) are pathogenetic events most commonly occurring in myelofibrosis (MF). There is great evidence indicating that tumor microenvironment characterized by high lactate levels, acting not only as an energetic source, but also a signaling molecule. To test involvement MF milieu transformation, we measured its levels patients' sera, eventually finding massive accumulation this metabolite, which showed to promote expansion...
Increasing evidences showed that the location of primary tumor on right (proximal) or left (distal) side colon have a prognostic/predictive value for cancer patients. However, understanding molecular mechanisms contribute to pathogenesis in different is still unclear. Probably an important role could be played by genes control spatial–temporal development bodily structures, such as HOX genes. The main purpose this study was analyze expression paralogous 13 and regulating lncRNA HOTAIR distal...
Colorectal cancer (CRC) is the second most common cause of cancer-specific death in both sexes Western countries. KRAS mutations occur about 50% metastatic CRCs (mCRCs). The prognostic value specific still remains unexplored and unclear.Two hundred forty wild-type 206 KRAS/NRAS mutant consecutive unresectable mCRC patients with PS Eastern Cooperative Oncology Group (ECOG) 0 or 1, aged < 80 years, a life expectancy >3 months entered into this study. DNA was extracted from paraffin-embedded...
Genetic dynamics underlying cancer progression are largely unknown and several genes involved in highly prevalent illnesses (e.g., hypertension, obesity, diabetes) strongly concur to phenotype heterogeneity. To study genotype-phenotype relationships contributing the mutational evolution of colorectal (CRC) with a focus on liver metastases, we performed genome profiling tumor tissues CRC patients metastatic disease no co-morbidities. We studied 523 cancer-related tumor-immune microenvironment...
Background and aims: Post-operative atrial fibrillation (POAF), defined as new-onset AF in the immediate period after surgery, is associated with poor adverse cardiovascular events a higher risk of permanent AF. Mechanisms leading to POAF are not completely understood epicardial adipose tissue (EAT) inflammation could be potent trigger. Here, we aim at exploring link between EAT-secreted interleukin (IL)-1β, remodeling, population coronary artery disease (CAD) patients. Methods: We collected...
Neuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the ability to secrete peptide hormones and biogenic amines but other reliable biomarkers lacking, making diagnosis identification primary site very challenging. While in some NENs, such as pancreatic ones, next generation sequencing technologies allowed new molecular hallmarks, our knowledge profile NENs from anatomical sites is still poor.Starting concept that...
Genetics and immunologic dynamics pushing the evolution of colorectal cancer (CRC) from primary tumor to metastases are largely unknown; heterogeneity makes challenging both therapy mechanistic studies. We selected patients developing CRC with lung-limited metastatic disease as only illness during their life in order find any relevant genotype-phenotype relationship. Analysis 523 cancer-relevant genes immune cells infiltration tissues revealed atypical genomic trajectories (TMB decrease,...
Anthracyclines are essential adjuvant therapies for a variety of cancers, particularly breast, gastric and esophageal cancers. Whilst prolonging cancer-related survival, these agents can induce drug-related cardiotoxicity. Spirulina, Reishi (Ganoderma lucidum) Moringa three nutraceuticals with anti-inflammatory effects that currently used in cancer patients as complementary alternative medicines to improve quality life fatigue. We hypothesize the nutraceutical combination (Singo) could...
The present study was undertaken to analyze prognostic and genetic interactions between type 2 diabetes metastatic colorectal cancer. Patients' survival depicted through the Kaplan-Meier product limit method. Prognostic factors were examined Cox proportional-hazards regression model, associations clinical-pathologic variables evaluated by χ2 test. In total, 203 cancer patients enrolled. Lymph nodes (P = 0.0004) distant organs (> sites, P 0.0451) more frequently involved in diabetic compared...
The Immunoscore (IS) is a quantitative digital pathology assay that evaluates the immune response in cancer patients. This study reports on reproducibility of pathologists' visual assessment CD3+- and CD8+-stained colon tumors, compared to IS quantification.An international group expert pathologists evaluated 540 images from 270 randomly selected (CC) cases. Concordance between T-score, corresponding hematoxylin-eosin (H&E) slides, was for two- three-category IS.Non-concordant T-scores were...