A5058691292- Colorectal Cancer Treatments and Studies
- Advanced Radiotherapy Techniques
- Gastric Cancer Management and Outcomes
- Cancer Treatment and Pharmacology
- Hepatocellular Carcinoma Treatment and Prognosis
- Medical Imaging Techniques and Applications
- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Colorectal and Anal Carcinomas
- Radiation Therapy and Dosimetry
- Genetic factors in colorectal cancer
- Management of metastatic bone disease
- Cardiovascular Function and Risk Factors
- Breast Cancer Treatment Studies
- Prostate Cancer Treatment and Research
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Head and Neck Cancer Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Advanced X-ray and CT Imaging
- Monoclonal and Polyclonal Antibodies Research
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2016-2025
University of Padua
2024
Università Cattolica del Sacro Cuore
2020-2023
University of Molise
2022-2023
Centro di Riferimento Oncologico della Basilicata
2007-2009
Federico II University Hospital
2000-2008
Istituto Oncologico Veneto
2008
Istituti di Ricovero e Cura a Carattere Scientifico
2008
Presidio Ospedaliero
2007
University of Naples Federico II
2005
Left ventricular hypertrophy (LVH) is the most important independent marker of cardiovascular risk in adults with chronic kidney disease. Cardiovascular morbidity seems increased even children renal insufficiency (CRI), but age and stage CRI when cardiac alterations become manifest are unknown. For assessing prevalence factors associated abnormal LV geometry CRI, echocardiograms, ambulatory BP monitoring, biochemical profiles were obtained 156 aged 3 to 18 yr stages 2 through 4 disease (GFR...
Recent data have shown that cardiotoxicity represents a potentially important side-effect in patients treated with sunitinib. We reviewed cardiac adverse events metastatic renal cell carcinoma (RCC) who underwent treatment this agent.The medical records of 175 RCC sunitinib at eight Italian institutions were retrospectively reviewed. Alterations left ventricular ejection fraction (LVEF) and blood pressure evaluated. Patients preexisting risk factors specifically scrutinized for increased...
There might be limitations in identifying concentric left ventricular (LV) geometry by ratio of diastolic posterior wall thickness (WT p ) to cavity radius, defined as relative (RWT ). This study has been designed evaluate age effects on RWT . WT , mean septal and m ), radius were cross-sectionally evaluated 766 1- 85-year-old, normotensive, nonobese subjects 331 hypertensive Italians (used a test series). ≥0.43 “traditional” LV geometry. The ratios /radius increased 0.005 0.006 per year the...
// Massimiliano Berretta 1 , Chiara Della Pepa 2 Paolo Tralongo 3 Alberto Fulvi 4 Ferdinando Martellotta Arben Lleshi Guglielmo Nasti 5 Rossella Fisichella 6 Carmela Romano De Divitiis Rosaria Taibi Francesco Fiorica 7 Raffaele Di Francia 8, 9 Anna Mari Lino Del Pup 10 Crispo 11 Paoli 12 Adriano Santorelli 13 Vincenzo Quagliariello Rosario Iaffaioli Umberto Tirelli Gaetano Facchini Department of Medical Oncology, National Cancer Institute, Aviano (PN), Italy Division Uro-Gynaecological...
Abstract Despite the recent advanced developments in radiation therapy planning, treatment planning for head-neck and pelvic cancers remains challenging due to large concave target volumes, multiple dose prescriptions numerous organs at risk close targets. Inter-institutional studies highlighted that plan quality strongly depends on planner experience skills. Automated optimization of procedure may improve best practice. We performed a comprehensive dosimetric clinical evaluation Pinnacle 3...
Background —It is unclear whether impairment of left ventricular (LV) diastolic characteristics independent systolic dysfunction. Methods and Results —To address this issue, 159 consecutive hypertensive patients (44±11 years, 78 obese, 96 women) 165 normotensive subjects (32±11 84 110 were studied with the use Doppler echocardiography. After adjustment for age, body mass index (BMI), sex, we found that ejection fraction (EF; M-mode, z -derived) was higher in (66.6±5.2%) than (63.9±4.4%, P...
Abstract Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. Although SNPs in genes encoding are functionally relevant cetuximab-mediated ADCC colorectal cancer, direct correlation between vitro and clinical response cetuximab not defined. We therefore enrolled 96 consecutive metastatic cancer (mCRC) patients at diagnosis study assessed FcγR status ADCC. Patients carrying FcγRIIa H alleles 131H/H...
There are few background data on the impact of clinical factors neurotoxicity and prognosis in patients treated with adjuvant capecitabine oxaliplatin (CAPOX) chemotherapy.102 stage II high-risk III colorectal cancer were for 6 months CAPOX, then they followed up. Associations between variables, metabolic syndrome components, smoking evaluated by x03C7;2 test. The Kaplan-Meier product limit method was applied to graph disease-free survival (DFS). Univariate analysis done log-rank Cox's...
The aim of this work was to apply the 'win ratio' compare outcomes rectal-sparing approaches [watch and wait (WW) local excision (LE)] in management locally advanced rectal cancer responding neoadjuvant chemoradiotherapy. Patients enrolled ReSARCh study (NCT02710812) between 2016 2021 were divided into two cohorts (WW vs. LE). win ratio calculated by dividing number successes (or wins) WW group LE on matched pairs. Oncological (overall survival, distant recurrence), presence a stoma rectum...
We have previously shown that an intensified preoperative regimen including oxaliplatin plus raltitrexed and 5-fluorouracil/folinic acid (OXATOM/FUFA) during pelvic radiotherapy produced promising results in locally advanced rectal cancer (LARC). Preclinical evidence suggests the scheduling of bevacizumab may be crucial to optimize its combination with chemo-radiotherapy.This non-randomized, non-comparative, phase II study was conducted MRI-defined high-risk LARC. Patients received three...
Colorectal cancer (CRC) is the second most common cause of cancer-specific death in both sexes Western countries. KRAS mutations occur about 50% metastatic CRCs (mCRCs). The prognostic value specific still remains unexplored and unclear.Two hundred forty wild-type 206 KRAS/NRAS mutant consecutive unresectable mCRC patients with PS Eastern Cooperative Oncology Group (ECOG) 0 or 1, aged < 80 years, a life expectancy >3 months entered into this study. DNA was extracted from paraffin-embedded...
Abstract Background Anti-EGFR monoclonal antibodies have shown efficacy in the treatment of metastatic colorectal cancer (mCRC). One mechanism is antibody-dependent cell-mediated cytotoxicity (ADCC) which Fc region antibody binds to gamma receptors (FcγR) expressed by immune cells. The present study investigated association between single nucleotide polymorphisms FcγRIIa and FcγRIIIa clinical outcome mCRC treated with anti-EGFR antibodies. Methods Seventy-four consecutive patients were...
<h3>Importance</h3> Although bevacizumab is a standard of care in combination treatments for metastatic colorectal cancer (mCRC), its clinical benefit has been limited. <h3>Objective</h3> To determine whether sequential scheduling administration with chemotherapy improves treatment efficacy patients mCRC, keeping the tumor vascular normalization hypothesis. <h3>Design, Setting, and Participants</h3> This open-label, randomized phase 3 trial was conducted from May 8, 2012, to December 9,...
Radiation-induced skin toxicity is a common and distressing side effect of breast radiation therapy (RT). We investigated the use quantitative spectrophotometric markers as input parameters in supervised machine learning models to develop predictive model for acute toxicity.One hundred twenty-nine patients treated adjuvant whole-breast radiotherapy were evaluated. Two spectrophotometer variables, i.e. melanin (IM) erythema (IE) indices, used quantitatively assess physical changes....
Preoperative treatment of resectable liver metastases from colorectal cancer (CRC) is a matter debate. The aim this study was to assess the feasibility and activity bevacizumab plus FOLFIRI in setting. Patients aged 18–75 years, PS 0–1, with liver-confined CRC were eligible. They received 5 mg kg−1 followed by irinotecan 180 m−2, leucovorin 200 5-fluorouracil 400 m−2 bolus 2400 46-h infusion, biweekly, for 7 cycles. Bevacizumab stopped at cycle 6. A single-stage, single-arm phase 2 design...
Purpose: The aim of this study is to assess MRI features mucinous liver metastases compared non-mucinous and hepatic hemangioma. Methods: A radiological archive was assessed from January 2017 June 2021 select patients subjected resection for CRCLM in the staging phase. We selected 20 with hemangioma (study group B). evaluated (a) maximum diameter lesions, millimeters, on T1-W flash 2D phase out phase, axial HASTE T2-W portal VIBE T1 W; (b) signal intensity (SI) sequences, Diffusion-Weighted...