Anna Diana
A5049685931- Cholangiocarcinoma and Gallbladder Cancer Studies
- Advanced Breast Cancer Therapies
- Cystic Fibrosis Research Advances
- Breast Cancer Treatment Studies
- Neonatal Respiratory Health Research
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- PI3K/AKT/mTOR signaling in cancer
- Gallbladder and Bile Duct Disorders
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- PARP inhibition in cancer therapy
- Tracheal and airway disorders
- Ovarian cancer diagnosis and treatment
- Neuroendocrine Tumor Research Advances
- Vibrio bacteria research studies
- Pharmaceutical studies and practices
- Cancer Risks and Factors
- Liver Diseases and Immunity
Ospedale Santa Maria
2023
University of Campania "Luigi Vanvitelli"
2015-2022
University of Bari Aldo Moro
2009-2020
Azienda Ospedaliera Universitaria Università degli Studi della Campania Luigi Vanvitelli
2018
University of Naples Federico II
2015-2016
Regione Puglia
2014
Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari
2014
University of Cagliari
2007
University of Kentucky
1990
Abstract Background The TOPAZ‐1 phase III trial reported a survival benefit with the anti‐programmed death cell ligand 1 (anti‐PD‐L1) durvalumab in combination gemcitabine and cisplatin patients advanced biliary tract cancer. present study investigated efficacy safety of this new standard treatment real‐world setting. Methods analysed population included unresectable, locally or metastatic adenocarcinoma treated at 17 Italian centres. primary endpoint was progression‐free (PFS), whereas...
Background Pemigatinib is approved for patients with pretreated, locally advanced or metastatic CCA harboring FGFR2 rearrangements fusions. We aim to assess the effectiveness and safety of pemigatinib in real-world setting. Material Methods A joint analysis two multicentre observational retrospective cohort studies independently conducted France Italy was performed. All consecutive FGFR2-positive affected by treated as second- further line systemic treatment clinical practice, within outside...
ObjectiveTo assess the correlation between presurgery neutrophil to lymphocyte ratio (NLR) and distant metastasis-free survival (DMFS) in patients with early breast cancer.DesignRetrospective analysis.Participants300 Caucasian (T1–2, N0–1, non-metastatic) cancer who were followed from July 1999 June 2015 at our Institution.Main outcome measuresDistant (DMFS).ResultsOf whole populations (300 patients), 134 166 grouped as low high NLR, respectively, on basis of NLR value 1.97, established by...
Approximately 45-50% of breast cancers (BCs) have a HER2 immunohistochemical score 1+ or 2+ with negative in situ hybridization, defining the "HER2-low BC" subtype. No anti-HER2 agents are currently approved for this subgroup Europe, where treatment is still determined by HR expression status. In study, we investigated prognostic significance HER2-low status HR+/HER2- metastatic BC (MBC) patients treated endocrine therapy (ET) plus palbociclib as first line.We conducted retrospective study...
Pancreatic adenocarcinoma is an aggressive disease with poor prognosis. In a randomized phase III trial, combination of Nab-paclitaxel (Nab-P) plus gemcitabine showed superior activity and efficacy in first-line treatment compared alone.Nab-P not dispensed Italy; however, we obtained this drug from our Ethics Committee for compassionate use. The aim study was to evaluate the safety profile Nab-P cohort patients treated outside clinical trials. From January 2012 May 2014, included 41 advanced...
Abstract Background and Aims Cholangiocarcinoma (CCA), a rare aggressive hepatobiliary malignancy, presents significant clinical management challenges. Despite rising incidence evolving treatment options, prognosis remains poor, motivating the exploration of real‐world data for enhanced understanding patient care. Methods This multicenter study analyzed from 120 metastatic CCA patients at three institutions 2016 to 2023. Kaplan–Meier curves assessed overall survival (OS), while univariate...
The role of colony stimulating factors (CSFs) in cystic fibrosis (CF) circulating neutrophils has not been thoroughly evaluated, considering that the neutrophil burden lung inflammation these subjects is very high. aim this study was to assess granulocyte-CSF (G-CSF) and granulocyte-macrophage-CSF (GM-CSF) levels CF patients various clinical conditions how cytokines impact on activation priming neutrophils. G-CSF GM-CSF were measured sputum serum samples stable (n = 21) with acute...
Abstract Standard of care first‐line systemic treatment for advanced biliary tract cancer includes chemo‐immunotherapy with gemcitabine, cisplatin, and durvalumab, followed by maintenance durvalumab monotherapy. The present work aims to investigate the differences in baseline clinical molecular characteristics between patients early progression during those who reach therapy. study population included unresectable, locally advanced, or metastatic BTC received at 38 Institutions 12 countries...
Abstract Cystic fibrosis ( CF ) is caused by mutations in the transmembrane conductance regulator CFTR gene, with most of mortality given lung disease. Human amniotic mesenchymal stromal (stem) cells (h AMSC s) hold great promise for regenerative medicine field disease; however, their potential as therapeutics disease has not been fully explored. In present study, h s were analysed co‐cultures on Transwell filters immortalized airway epithelial CFBE 41o‐ line) at different ratios to exploit...
Platinum-based chemotherapy represents the standard first-line treatment for biliary tract cancers (BTC). Deficits in genes involved homologous recombination (HR) and DNA damage response (DDR) may confer higher sensitivity to platinum agents.
Cutaneous congenital candidiasis (CCC) is a very rare disease of the term or premature infant consisting generalized rash at shortly after birth usually without other signs symptoms. The presence white microabscesses on placenta and umbilical cord an with such must suggest diagnosis CCC, which always secondary to Candida chorioamnionitis but may pass unrecognized. Despite high prevalence vulvo‐vaginitis in pregnant women, CCC remains apparently extremely just some hundred cases described....
// Floriana Morgillo 1 , Carminia Maria Della Corte Anna Diana Concetta di Mauro 2 Vincenza Ciaramella Giusi Barra 3 Valentina Belli Elisena Franzese Roberto Bianco Evaristo Maiello 4 Ferdinando De Vita Fortunato Ciardiello and Michele Orditura Oncologia Medica, Dipartimento Internistica Clinica e Sperimentale "F. Magrassi", Università degli Studi della Campania "Luigi Vanvitelli", Napoli, Italy Medicina Chirurgia, Napoli "Federico II", Immunologia Clinica, IRCCS Casa Sollievo Sofferenza,...
Background . High neutrophil to lymphocyte ratio (NLR) has shown be a predictor of poor outcomes in various malignancies, including pancreatic cancer. Methods We assessed 70 consecutive pts with histologically confirmed mPC who received chemotherapy nab-paclitaxel/gemcitabine at two different European oncologic centers between January 2012 and November 2015. Variables for prognostic correlations included age ≥ 66, sex, Karnofsky PS score, primary tumor site, baseline CA19.9 level 59xULN,...
The pathogenicity of the Vibrio cholerae strains belonging to serogroup O1 and O139 is due production virulence factors such as cholera toxin (CT) toxin-coregulated pilus (TCP). remaining serogroups, which mostly lack CT TCP, are more frequently isolated from aquatic environmental sources than clinical samples; nevertheless, these have been reported cause human disease, sporadic outbreaks watery diarrhoea inflammatory enterocolitis. This evidence suggested possibility that other factor(s)...