A5004998760- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Carcinogens and Genotoxicity Assessment
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Mast cells and histamine
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Public health and occupational medicine
- Thyroid Cancer Diagnosis and Treatment
- Immune Response and Inflammation
- PI3K/AKT/mTOR signaling in cancer
- Ergonomics and Musculoskeletal Disorders
- Ferroptosis and cancer prognosis
- Fatty Acid Research and Health
- Effects and risks of endocrine disrupting chemicals
- RNA Research and Splicing
- Occupational Health and Safety in Workplaces
- Biomarkers in Disease Mechanisms
- Cancer Mechanisms and Therapy
- Obstructive Sleep Apnea Research
- Protein Tyrosine Phosphatases
University of Naples Federico II
2011-2025
Institute for Experimental Endocrinology and Oncology
2010-2023
National Research Council
2019
University of Perugia
1983-1993
Institute of General and Experimental Biology
1986
Background Colorectal cancer (CRC) is one of the most prevalent and deadly tumors worldwide. The majority CRC resistant to anti-programmed cell death-1 (PD-1)-based immunotherapy, with approximately 15% high-microsatellite instability, high tumor mutation burden, intratumoral lymphocytic infiltration. Programmed death-ligand 1 (PD-L1)/PD-1 signaling was described in solid cells. In melanoma, liver, thyroid cells, intrinsic PD-1 activates oncogenic functions, while lung it has a suppressor...
Thyroid cancer is the most common endocrine cancer, but its key oncogenic drivers remain undefined. In this study we identified TYRO3 and AXL receptor tyrosine kinases as transcriptional targets of chemokine CXCL12/SDF-1 in CXCR4-expressing thyroid cells. Both receptors were constitutively expressed cell lines not normal displayed high levels phosphorylation due to constitutive expression ligand GAS6. human carcinoma specimens, tissues, GAS6 often coexpressed. expressing both ligand,...
Abstract Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 PD-L2 are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express the PD-Ls bind PD-1 on cells, inhibiting their activity. Recently, expression has also been found in cells. Here, we analysed functions of thyroid (TC). Methods was evaluated by immunohistochemistry human TC samples RT-PCR, western blot FACS lines. Proliferation migration culture were assessed BrdU incorporation...
AXL is a tyrosine kinase receptor activated by GAS6 and regulates cancer cell proliferation migration angiogenesis. We studied as new therapeutic target in colorectal (CRC). Expression activation of were evaluated panel human CRC lines. gene silencing or pharmacologic inhibition with foretinib suppressed proliferation, survival cells. In an orthotopic colon model HCT116 cells overexpressing AXL, treatment caused significant tumour growth peritoneal metastatic spreading. overexpression...
Chronic inflammation can result from inadequate engagement of resolution mechanisms, mainly accomplished by specialized pro-resolving mediators (SPMs) arising the metabolic activity lipoxygenases (ALOX5/15) on ω-6 or ω-3 essential polyunsaturated fatty acids (PUFA). We previously demonstrated that formyl peptide receptor 1 (FPR1) suppresses gastric cancer (GC) inhibiting its inflammatory/angiogenic potential. In this study, we asked whether FPR1 exploits pathways to suppress GC angiogenesis...
Interleukin-8 (IL-8/CXCL8) mediates its biological effects through two receptors, CXCR1 and CXCR2. While recognizes IL-8 granulocyte chemotactic protein-2, CXCR2 binds to multiple chemokines including IL-8, CXCL1, 2 3. Both CXCL1 have been implicated in the neoplastic features of thyroid cancer (TC). Here, we assessed role autocrine circuits sustained by determining TC stem cell (TC SC) features. Using immunohistochemistry, found that epithelial cancerous, but not normal, cells stained...
// Federica Liotti 1 , Maria De Pizzol 2 Marcello Allegretti Nella Prevete 3, 4 Rosa Marina Melillo 1, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples "Federico II", Naples, Italy Dompé Farmaceutici S.p.A., L'Aquila, 3 Scienze Mediche Traslazionali, Istituto Endocrinologia ed Oncologia Sperimentale del CNR "G. Salvatore", Correspondence to: Melillo, email: rosmelil@unina.it Prevete, nella.prevete@unina.it Keywords: Reparixin, thyroid cancer, CXCR1, CXCR2...
Papillary thyroid carcinomas (PTCs) have an excellent prognosis, but a fraction of them show aggressive behavior, becoming radioiodine (RAI)-resistant and/or metastatic. AXL (Anexelekto) is tyrosine kinase receptor regulating viability, invasiveness and chemoresistance in various human cancers, including PTCs. Here, we analyze the role PTC prognosis as marker RAI refractoriness. Immunohistochemistry was used to assess positivity cohort samples. Normal cancerous cell lines were vitro for...
Adiposity and diabetes affect breast cancer (BC) progression. We addressed whether glucose may the interaction between mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs) BC cells. Two-dimensional co-cultures spheroids were established in 25 mM or 5.5 (High Glucose-HG Low Glucose-LG) by using MAT-MSCs MCF7 MDA-MB231 Gene expression was measured qPCR, while protein levels cytofluorimetry ELISA. CD44high/CD24low stem-like sub-population quantified cytofluorimetry. An vivo...
<ns4:p>Tumors modulate the host immune cells within their microenvironment to avoid recognition and elimination by our system, a phenotype called cancer escape. Different mechanisms responsible for escape that result either in decreased tumor immunogenicity or increased immunosuppressive activity have been identified. Recently, various immunotherapeutic approaches developed with aim revert The aims of this review are explore immunological aspects thyroid assess whether these features can be...
Formyl peptide receptors (FPR1, FPR2 and FPR3) are innate immune sensors of pathogen commensal bacteria have a role in colonic mucosa homeostasis. We identified FPR1 as tumour suppressor gastric cancer cells due to its ability sustain an inflammation resolution response with antiangiogenic potential. Here, we investigate whether exerts similar functions colorectal carcinoma (CRC) cells. Since it has been shown that the bacterium Lactobacillus rhamnosus GG (LGG) can promote intestinal...
Oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinomas show high morbidity mortality rates. We aimed to investigate the role of “Chromatin Assembly Factor-1” (CAF-1) p60 p150 subunits, involved in DNA repair replication, OSCC OPSCC progression response Poly(ADP-ribose) polymerase (PARP)-inhibitors exposure ionizing radiation (IR). immunostained tissue microarrays (TMAs), including 112 42 OPSCC, with anti-CAF-1/p60 anti-CAF-1/p150 specific antibodies, correlating their expression...
Pattern recognition receptors (PRR) promote inflammation but also its resolution. We demonstrated that a specific PRR—formyl peptide receptor 1 (FPR1)—sustains an resolution response with anti-angiogenic and antitumor potential in gastric cancer. Since toll-like 7 (TLR7) is crucial the physiologic of airway inflammation, we asked whether it could be responsible for pro-resolving responses non-small cell lung cancer (NSCLC). TLR7 correlated directly inversely angiogenic mediators NSCLC...
Abstract Thyroid cancer is the most prevalent endocrine malignancy and comprises a wide range of lesions subdivided into differentiated (DTC) undifferentiated thyroid (UTC), mainly represented by anaplastic carcinoma (ATC). This one lethal malignancies in humankind leading invariably to patient death few months. Then, better comprehension mechanisms underlying development ATC required set up new therapeutic approaches. Long non-coding RNAs (lncRNAs) are transcripts over 200 nucleotides...