A5056723399- Lymphoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Ocular Oncology and Treatments
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- AI in cancer detection
- Head and Neck Cancer Studies
- CNS Lymphoma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- Prostate Cancer Treatment and Research
- Nonmelanoma Skin Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- CAR-T cell therapy research
- RNA Research and Splicing
- Ovarian cancer diagnosis and treatment
- Immunotherapy and Immune Responses
- Plant Virus Research Studies
University of Naples Federico II
2015-2025
Federico II University Hospital
2017-2024
Advanced Computer System (Italy)
2019-2020
Anti-programmed cell death 1 (PD1) is the first-choice treatment in patients with advanced cutaneous squamous carcinoma (cSCC), when curative options are unavailable. However, reliable biomarkers for patient selection still lacking. In this translational study, clinical annotations, tissue and liquid biopsies were acquired to investigate association between sustained objective responses transcriptional profiles, immune dynamics tumor peripheral blood samples, as well circulating cytokine...
Abstract Epithelial tumor progression often involves epithelial-mesenchymal transition (EMT). We report that increased intracellular levels of thyroid hormone (TH) promote the EMT and malignant evolution squamous cell carcinoma (SCC) cells. TH induces by transcriptionally up-regulating ZEB-1, mesenchymal genes metalloproteases suppresses E-cadherin expression. Accordingly, in human SCC, elevated D2 (the T3-producing enzyme) correlates with grade is associated an risk postsurgical relapse...
PReferentially expressed Antigen in Melanoma (PRAME) is a cancer testis antigen, first isolated tumor-reactive T-cell clones from metastatic melanoma patient. It has been widely studied skin pathology as an immunohistochemical marker capable of distinguishing between benign nevi and malignant melanomas. PRAME found to be also non-melanocytic tumors, including lung, breast, kidney ovarian cancer. However, less known about the diagnostic and/or prognostic role this protein uveal (UM); few...
Uveal melanoma, in spite of its rarity, represents the most common primitive intraocular malignant neoplasm adults; it affects choroid, ciliary bodied and iris remains clinically silent for a long time, being accidentally discovered by routine ophthalmic exams. Prognosis uveal melanoma is poor frequently characterized liver metastases, within 10–15 years from diagnosis. Autophagy multi-step catabolic process which cells remove damaged organelles proteins recycle nutrients. It has been...
Choroidal melanoma (CM), despite its rarity, is the most frequent intraocular malignancy. Over time, several histological variants of CM have been distinguished, including spindle A and B cell, fascicular, epithelioid necrotic type. However, they progressively abandoned as having no prognostic value currently, American Joint Committee Cancer (AJCC) classification identifies three cell types: spindle, mixed Other rare include: (i) diffuse melanoma; (ii) clear cell; (iii) balloon melanoma....
MacroH2A1 has two splice isoforms, macroH2A1.1 and macroH2A1.2, that have been studied in several form of cancer. In the literature there are not many scientific papers dealing with role macroH2A1 breast Breast cancer is most frequent malignancy females. It tend to metastasize bone approximately 70% patients. Despite treatment, new metastases will still occur 30%-50% cases advanced disease. Overall 5-year survival after diagnosis metastasis 20%. Osteoclasts osteoblasts microenvironment...
Up-to-date, several molecular markers of prognosis have been studied in Oral Squamous Cell Carcinoma (OSCC), but none entered the clinical setting. Therapy OSCC tumors mainly relies on surgery, radiotherapy and partially chemotherapy; there is an urgent need for biomarkers able to better stratify patients' risk address targeted therapeutic strategies. The role immune response pathogenesis biological behavior has investigated by authors, promising results obtained with checkpoint inhibitors....
Uveal melanoma (UM) is the most common intraocular tumor in adults. Despite sharing name and similar morphological features with cutaneous (CM), it an entirely different neoplasia a particular genetic background clinical behavior. CDKN2A gene located at chromosome 9p21, encoding for P16INK4a P14(ARF) proteins, whose role as suppressor has been clearly defined many malignant tumors. frequently presents germline mutations familial CM epigenetic downregulation considerable percentage of...
We introduce a machine learning-based analysis to predict the immunohistochemical (IHC) labeling index for cell proliferation marker Ki67/MIB1 on cancer tissues based morphometrical features extracted from hematoxylin and eosin (H&E)-stained formalin-fixed, paraffin-embedded (FFPE) tumor tissue samples. provided proof-of-concept prediction of IHC positivity cells through definition quantitation single nuclear features. In first instance, we set our digital framework Ki67/MIB1-stained OSCC...
Abstract The reliability and safety of front‐line ultrasonography guided core needle biopsy (UG‐CNB) performed with specific uniform approach have never been evaluated in a large series patients lymphadenopathies suspected lymphoma. aim this study was to assess the overall accuracy UG‐CNB lymph node histological diagnosis, using standard reference based on pathologist consensus, molecular biology, and/or surgery. We retrospectively checked findings concerning application from four Italian...
Background: Despite advances in uveal melanoma (UM) diagnosis and treatment, about 50% of patients develop distant metastases, thereby displaying poor overall survival. Molecular profiling has identified several genetic alterations that can stratify with UM into different risk categories. However, these are currently dispersed over multiple studies methodologies, emphasizing the need for a defined workflow will allow standardized reproducible molecular analyses. Methods: Following findings...
Splenomegaly is a quite common clinical feature of Philadelphia (Ph) negative chronic myeloproliferative neoplasms (MPNs) and its presence may, in some cases, drives treatment decision. Most importantly, palpable splenomegaly minor criterion for both pre-fibrotic/early primary myelofibrosis (PMF) diagnosis, even if assessment by physical examination poorly reliable accurate. On the other hand, despite International Working Group-Myeloproliferative Neoplasms Research Treatment European...
227 Background: Metastatic hormone-sensitive prostate cancers (mHSPC) are generally sensitive to androgen deprivation therapy (ADT). However, resistance often occurs, leading disease progression. Understanding the transcriptomic changes underpinning shift antiandrogen is crucial for identification of novel therapeutic vulnerabilities. Methods: Sixty patients with mHSPC undergoing ADT plus receptor pathway inhibitors (ARPI) were enrolled. We defined non-responder (NR) (13/60) biochemical/...
Background: the treatment of squamous cell carcinomas oral cavity (OSCCs) is limited by lack reliable diagnostic/prognostic, and predictive markers, as well intrinsic tumor heterogeneity. 5-azacytidine (5-AZA) offers opportunities for cancer reprogramming to develop new target-specific treatments. The protein annexin A1 (ANXA1) downregulated in head neck carcinoma (HNSCC), correlated with pathological differentiation grade. Objectives: this work aimed further investigate role ANXA1 OSCC...
Abstract Introduction: Despite the expanding landscape of antibody-drug conjugates (ADCs), patient selection remains challenging due to limited liquid biopsy methods for target assessment. Current tissue approaches lack longitudinal assessments and provide insufficient resolution expression heterogeneity that could inform ADC selection. We present first platform specifically designed therapy, treatment through single-cell RNA sequencing circulating tumor cells (CTCs). This provides...