A5026444557- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Erythrocyte Function and Pathophysiology
- Biomedical Research and Pathophysiology
- MicroRNA in disease regulation
- GDF15 and Related Biomarkers
- Plasmonic and Surface Plasmon Research
- Chemical Synthesis and Analysis
- Apelin-related biomedical research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Mesoporous Materials and Catalysis
- Macrophage Migration Inhibitory Factor
- Bone Tissue Engineering Materials
- Advanced Nanomaterials in Catalysis
- Carbon and Quantum Dots Applications
- Nanoparticle-Based Drug Delivery
- Cardiovascular Disease and Adiposity
- Renal and related cancers
- Graphene and Nanomaterials Applications
- Nanocluster Synthesis and Applications
- Cardiovascular Effects of Exercise
- bioluminescence and chemiluminescence research
- Nutrition and Health in Aging
Mayo Clinic in Florida
2024
University of Milan
2022
Ospedale San Paolo
2022
Innova (Italy)
2020
Centro di Riferimento Oncologico
2016-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2019
University of Padua
2015-2018
Cluster in Biomedicine
2015
To demonstrate that exosomes (exo) could increase the therapeutic index of doxorubicin (DOX).Exosomes were characterized by nanoparticle tracking analysis and western blot. Tissue toxicity was evaluated histopathological drug efficacy measuring tumor volume. DOX biodistribution analyzed MS.Exosomal (exoDOX) avoids heart partially limiting crossing through myocardial endothelial cells. For this reason, mice can be treated with higher concentration exoDOX thus increasing as demonstrated in...
To test the efficacy and toxicity of exosomal doxorubicin (exoDOX) compared with free doxorubicin.The cytotoxic effects exoDOX were tested in vitro nude mice by measuring tumor volume. The toxic evaluated bodyweight through histopathologic analyses. biodistribution DOX was assessed MS.In vivo studies showed that exosomes did not decrease DOX. Surprisingly, no cardiotoxicity as observed DOX-treated MS confirmed accumulation heart reduced approximately 40%.We demonstrated less than its altered...
DNA origami systems could be important candidates for clinical applications. Unfortunately, their intrinsic properties such as the activation of non-specific immune system responses leading to inflammation, instability in physiological solutions, and a short vivo lifetime are major challenges real world A compact tube (STDO) 30 nm length 10 width was designed fit inside core stealth liposome (LSTDO) about 150 remote load doxorubicin. Biocompatibility tested three-dimensional (3D) organoid...
One of the most promising applications DNA origami is its use as an excellent evolution nanostructured intelligent systems for drug delivery, but short in vivo lifetime and immune-activation are still major challenges to overcome. On contrary, stealth liposomes have long-circulation time well tolerated by immune system. To overcome limitations, we designed synthesized a compact tube (STDO) approximately 30 nm length 10 width. These STDO highly stable ≥48 h physiological conditions without...
Severe/critical COVID-19 is associated with immune dysregulation and plasmatic SARS-CoV-2 detection (i.e. RNAemia). We detailed the association of RNAemia responses in patients at end first week disease. enrolled hospitalized acute phase ascertained pneumonia, evaluated RNAemia, cytokines, activated/pro-cytolytic T-cells phenotypes, SARS-CoV-2-specific cytokine-producing (IL-2, IFN-γ, TNF-α, IL-4, IL-17A), simultaneous Th1-cytokines production (polyfunctionality) amount (iMFI). The humoral...
In cancer therapy, it is imperative to increase the efficacy and reduce side effects of chemotherapeutic drugs. Nanotechnology offers unique opportunity overcome these barriers. particular, in last few years, DNA nanostructures have gained attention for their biocompatibility, easy customized synthesis ability deliver drugs cells. Here, an open-caged pyramidal DNA@Doxorubicin (Py-Doxo) nanostructure was constructed with 10 sequences 26-28 nucleotides drug delivery The synthesized are...
Nanocarriers as theranostic agents are under the spotlight in modern nanomedicine, and mesoporous nanomaterials represent a class of devices major interest. Zirconia is biocompatible, inert with good mechanical thermal properties for vivo biomedical applications. Although few examples zirconia nanoparticles have been described, limitation was low surface area, which fundamental payload transport. Here, simple highly efficient method described synthesis spherical (MZNs) high area through...
Key Points PIEZO1 activation reduces cystogenesis: Yoda1 activates PIEZO1, raising calcium and lowering cAMP, reducing cyst growth in autosomal dominant polycystic kidney disease models. Context-dependent role of PIEZO1: knockout mice with or without kidneys does not affect formation, suggesting redundancy mechanosensitive pathways. Therapeutic potential: Findings support as a part combination therapy to slow disease, needing more vivo studies. Background The disruption signaling associated...
A cytokine storm drives the pathogenesis of severe COVID-19 infection and several biomarkers have been linked to mortality. Chronic kidney disease (CKD) emerged as a risk factor for COVID-19. We investigated association between selected mortality in 77 patients hospitalized COVID-19, whether they differ with eGFR higher lower than 45 mL/min. The patients’ characteristics, plasma was conducted by univariate logistic regression models independent predictors were then used create multivariate...
Abstract Exosomes are nanovesicles produced by cells embedded of cellular information and represent a formidable natural cargo for communication. The name “FedExosomes” denotes the general idea that exosomes could deliver conveniently manipulated be help patient therapy. Up to now, few papers demonstrated modified drugs specifically cancer many laboratories now studying their properties compositions. Differently from previously published focused on efficacy doxorubicin encapsulated in...
The disruption of calcium signaling associated with polycystin deficiency has been proposed as the primary event underlying increased abnormally patterned epithelial cell growth characteristic Polycystic Kidney Disease. Calcium can be regulated through mechanotransduction, and mechanosensitive cation channel Piezo1 implicated in sensing intrarenal pressure urinary osmoregulation. However, a possible role for PIEZO1 kidney cystogenesis remains undefined. We hypothesized that ADPKD reflects...
Abstract BACKGROUND AND AIMS A cytokine storm drives the pathogenesis of severe coronavirus disease (COVID-19) and several biomarkers with different mechanisms action have been linked to mortality. Chronic kidney (CKD) emerged as a very common risk factor for COVID-19. Indeed, CKD patients are at increased premature death from many causes, including, but not limited to, cardiovascular (CVD) infections. In this study, we aimed investigate associations between growth differentiation 15...
Background: Thousands of people are dying as a result infections caused by bacteria. Among the main routes germ transmission hands, making hand hygiene very important in preventing spread pathogens and bacterial infection. Hand washing with soap water is considered to be simple effective measure. Old manufacturers have long had traditional uses Lebanese community. Methods: The purpose this study compare antibacterial activity oil-based soaps commercial sold market. Different types herbal...