A5036337907- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Melanoma and MAPK Pathways
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- CAR-T cell therapy research
- Nutritional Studies and Diet
- Metabolism, Diabetes, and Cancer
- SARS-CoV-2 detection and testing
- Cancer Risks and Factors
- Chemotherapy-induced cardiotoxicity and mitigation
- Cutaneous Melanoma Detection and Management
- Neuroendocrine Tumor Research Advances
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- COVID-19 and healthcare impacts
- Immune cells in cancer
- Colorectal Cancer Treatments and Studies
- Lung Cancer Research Studies
- Diet and metabolism studies
- Multiple Myeloma Research and Treatments
- Neuroblastoma Research and Treatments
- Cancer survivorship and care
- Cancer Treatment and Pharmacology
- Microtubule and mitosis dynamics
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Fondazione IRCCS Istituto Nazionale dei Tumori
2014-2021
Centro di Riferimento Oncologico
2021
Tumori Foundation
2020
University of Naples Federico II
1989
Previous studies have suggested that elevated neutrophil-to-lymphocyte ratio (NLR) is prognostic for worse outcomes in patients with a variety of solid cancers, including those treated immune checkpoint inhibitors.This was retrospective analysis 97 consecutive stage IV melanoma who were nivolumab. Baseline NLR and derived (d) calculated and, along other characteristics, correlated progression-free survival (PFS) overall (OS) univariate multivariate analyses. The best cutoff values dNLR using...
Abstract Background Inefficient T-cell access to the tumor microenvironment (TME) is among causes of immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME. To evaluate role newly developed antagonists (PCT/IB2011/000120/ EP2528936B1/US2013/0079292A1) in potentiating anti-PD-1 two syngeneic murine models, MC38 colon cancer and B16 melanoma-human CXCR4-transduced, were employed. Methods Mice subcutaneously injected with (1 × 10 6...
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes HRQoL after a 12-month lifestyle modification program 227 BC survivors participating DEDiCa trial (Mediterranean diet, exercise, vitamin D). was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 EORTC QLQ-BR23. Baseline were tested using analysis variance. Multiple regression analyses performed...
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality life (HRQoL) in healthy subjects. HRQoL is relevant cancer therapy and disease outcomes, therefore we investigated association between adherence to MedDiet breast survivors participating multicentre trial DEDiCa. were assessed at baseline subgroup 309 women enrolled within 12 months diagnosis without metastasis (stages I-III, mean age 52±1 yrs, BMI 27±7 kg/m2). The 14-item PREDIMED questionnaire...
Abstract Background Identifying response markers is highly needed to guide the treatment strategy in patients with metastatic melanoma. Methods A retrospective study was carried out unresectable/metastatic melanoma (stage IIIb–IV), treated anti-PD-1 first line setting, better explore role and timing of neutrophil/lymphocyte ratio (NLR) as potential biomarker response. The relationship NLR inflammation-immune mediators underlying negative effect raising during immunotherapy, have been...
Recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) has a poor prognosis combination cisplatin cetuximab, with or without 5-fluorouracil, is gold standard treatment in this stage. Thus, concomitant use novel compounds represents critical strategy to improve results. Histone deacetylase inhibitors (HDACi) enhance activity several anticancer drugs including anti-Epidermal Growth Factor Receptor (anti-EGFR) compounds. Preclinical studies models have shown that vorinostat...
The Metabolic syndrome (MetS) is an emerging condition worldwide, consistently associated with increased risk of several cancers. Some information exists on urothelial carcinoma the bladder (UCB) and MetS. This study aims at further evaluating association between MetS UCB. Between 2003 2014 in Italy, we conducted a hospital-based case-control study, enrolling 690 incident UCB patients 665 cancer-free matched patients. was defined as presence least three four selected indicators: abdominal...
Renal cell carcinoma (RCC) represents the main renal tumors and are highly metastatic. Sunitinib, a recently-approved, multi-targeted Tyrosine Kinases Inhibitor (TKi), prolongs survival in patients with metastatic gastrointestinal stromal tumors, however dose related cardiotoxicity was well described. Polydatin (3,4',5-trihydroxystilbene-3-β-d-glucoside) is monocrystalline compound isolated from Polygonum cuspidatum consolidated anti-oxidant anti-inflammatory properties, no studies...
Pheochromocytomas (PCCs) and Paragangliomas (PGLs), commonly known as PPGLs to include both entities, are rare neuroendocrine tumors that may arise in the context of hereditary syndromes or be sporadic. However, even among sporadic PPGLs, identifiable somatic alterations at least one susceptibility genes can detected. Therefore, about 3/4 all PPGL patients assigned three molecular clusters have been identified last years with difference underlying pathogenetic mechanisms, biochemical...
Aurora kinase A (AurkA) is over-expressed in melanoma and its inhibition has been observed to limit tumor growth, suggesting a potential role treatment. human cell line with the B-RAF (V600E) mutation (A375mel) was exposed inhibitor (GSK2118436), MEK (GSK1120212) AurkA (MLN8054) as single agents or various combinations (BRAF plus inhibitor, triple combination BRAF inhibitor). Cell proliferation assessed using xCELLigence technology. Total protein extracts were examined for p53 c-Myc...
Abstract Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for outcome, correctly select who will benefit from anti-PD-1 treatment. The aim this study was investigate the role peripheral CD8+T cells expressing CD73, involved generation immune suppressive molecule adenosine, predicting outcome after...
Abstract Background Prognostic factors for initial response of advanced cutaneous squamous cell carcinoma to cemiplimab treatment are lacking. Il-6 has been found affect immune populations which impact tumor development. The aim was investigate the prognostic significance IL-6 serum levels before and during treatment. Methods Serum were correlated with clinical outcomes in a retrospective study. Results Overall, 39 patients enrolled. High (> 5.6 pg/ml) associated poorer survival (45.1% vs...
Abstract The entire SARS-CoV-2 proteome was scanned to predict potential T cell antigens linked HLA-A*02:01 and homology TAAs (tumor-associated antigens) searched by BLAST. Viral epitopes with high affinity (<100nM) the allele were predicted. Shared variant-specific identified. Significant homologies in amino acidic sequence have been found between peptides multiple TAAs, mainly associated breast, liver, melanoma colon cancers. molecular mimicry of viral all proteins, mostly Orf 1ab...
Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age body mass index. Although link between obesity, hormone related cancer incidence now widely recognized, molecular mechanisms at basis of such increase are still poorly characterized. A crucial role supposed be played by altered insulin signalling, occurring obese patients, which fuels cell growth, proliferation survival. Therefore we focused specifically...
Mechanisms influencing breast cancer (BC) development and recurrence include hyperglycemia, hyperinsulinemia, high insulin-like growth factor-1, circulating estrogen, inflammation impaired cellular differentiation/apoptosis. A lifestyle program that targets all the above mechanisms may be warranted. Low glycemic index (GI) foods produce lower post-prandial glucose insulin responses have been associated with BC risk. Moderate physical activity post-diagnosis reduces mortality, partly...
Locally advanced rectal cancer (LARC) is a heterogeneous group of tumors where risk-adapted therapeutic strategy needed. Short-course radiotherapy (SCRT) more convenient option for LARC patients than preoperative long-course RT plus capecitabine. Histone-deacetylase inhibitors (HDACi) have shown activity in combination with and chemotherapy the treatment solid tumors. Valproic acid (VPA) an anti-epileptic drug HDACi anticancer activity. In preclinical studies, our showed that addition HDACi,...
Abstract Background The clinical observation showed a potential additive effect of anti-PD-1 agents and cetirizine in patients with advanced melanoma. Methods Clinical outcomes concomitant cetirizine/anti-PD-1 treatment stage IIIb–IV melanoma were retrospectively collected, transcriptomic analysis was performed on blood samples obtained at baseline after 3 months treatment. Results Patients treated concomitantly an agent had significantly longer progression-free survival (PFS; mean PFS: 28...
In the present study, phenotype of melanoma cells resistant to dabrafenib (a B-RAF inhibitor) was investigated, shed more light on resistance inhibition. Melanoma were generated using 3 different cell lines, A375, 397 and 624.38, all carrying B-RAFV600E, they characterized by cytofluorometric analysis, Ion Torrent technology, immunofluorescence biochemistry. All dabrafenib-resistant showed, in addition a re-activation MAPK signaling, morphological changes compared their sensitive...
Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is a devastating malignancy with poor prognosis. The combination of cisplatin (CDDP) plus cetuximab (CX) one the standard first-line treatments in this disease. However, therapeutic regimen often associated high toxicity resistance, suggesting that new combinatorial strategies are needed to improve its index. In our study, we evaluated antitumor effects valproic acid (VPA), well-known antiepileptic agent histone...
The response to anti-SARS-Cov-2 preventive vaccine shows high interpersonal variability at short and medium term. One of the explanations might be individual HLA allelic variants. Indeed, B cell is stimulated sustained by CD4 + T helper cells activated antigens presented HLA-class II alleles on antigen-presenting (APCs). impact number binding class-II antibody COVID has been assessed in a cohort 56 healthcare workers who received full schedule Pfizer-BioNTech BNT162b2 vaccine. Such based...
Background/Aim: Patients affected by liver cirrhosis are at high risk for developing hepatocellular carcinoma (HCC). The aim of this study was to evaluate the feasibility PIVKA-II (protein induced vitamin K absence or antagonist-II) alone in combination with α-1 fetoprotein (AFP), as a screening marker development HCC. Materials and Methods: A case-control conducted 2 hospital wards Naples. All anti-HCV-positive patients HCC were considered cases, while consecutive without controls. Results:...
Abstract Background Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and the resulting disease, coronavirus disease 2019 (COVID-19), have spread to millions of people globally, requiring development billions different vaccine doses. The SARS-CoV-2 spike mRNA (named BNT162b2/Pfizer), authorized by FDA, has shown high efficacy in preventing after administration two doses individuals 16 years age older. In present study, we retrospectively evaluated differences humoral...