A5086548837- Breast Cancer Treatment Studies
- Metabolism, Diabetes, and Cancer
- Breast Implant and Reconstruction
- Cancer Risks and Factors
- Breast Lesions and Carcinomas
- Cancer, Lipids, and Metabolism
- Reconstructive Surgery and Microvascular Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer and Skin Lesions
- Advanced Radiotherapy Techniques
- Advances in Oncology and Radiotherapy
- Dermatologic Treatments and Research
- HER2/EGFR in Cancer Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Colorectal Cancer Surgical Treatments
- Cancer Diagnosis and Treatment
- Body Contouring and Surgery
- Global Cancer Incidence and Screening
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Treatment and Pharmacology
- Head and Neck Cancer Studies
- BRCA gene mutations in cancer
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2013-2025
Hospital de Mataró
2024
Maresme Health Consortium
2024
University of Naples Federico II
2000-2024
King's College London
2015-2018
Guy's Hospital
2015-2018
Ceinge Biotecnologie Avanzate (Italy)
2016
Ospedale Policlinico San Martino
2016
University of Cagliari
2016
Federico II University Hospital
2014-2016
Postmenopausal women show the highest incidence of breast cancer in female population and are often affected by metabolic syndrome. Metabolic syndrome (MS) - characterized central adiposity, insulin resistance, low serum high-density lipoprotein cholesterol (HDL-C), high triglyceride blood pressure seems to be strictly correlated carcinogenesis. We enrolled 777 healthy with our nested case-control study evaluate association between MS cancer, analyzing anthropometric parameters (weight,...
Abstract Purpose Obesity and insulin resistance have been associated with poor prognosis in breast cancer (BC). The present prospective study aimed to investigate the impact of metabolic syndrome (MetS) its components on early BC (eBC) patients’ outcome. Methods MetS was defined by presence 3 5 following components: waist circumference > 88 cm, blood pressure ≥ 130/≥ 85 mmHg, serum levels triglycerides 150 mg/dL, high density lipoprotein < 50 mg/dL fasting glucose 110 mg/dL. Seven...
Stage shift is widely considered a major determinant of the survival benefit conferred by breast cancer screening. However, factors and mechanisms underlying such prognostic advantage need further clarification. We sought to compare molecular characteristics screen detected vs. symptomatic cancers assess whether differences in tumour biology might translate into benefit. In clinical series 448 women with operable cancer, Kaplan-Meier method log-rank test were used estimate likelihood...
The improvement in cancer therapy and the increasing number of long term survivors unearth issue cardiovascular side effects anticancer treatments. As a paradox survivors, delayed cardiotoxicity has emerged as significant problem. Two categories cardiotoxic antineoplastic drugs have been previously proposed: Type I cardiotoxicity, defined permanent is usually caused by anthracyclines; II considered reversible mainly related to monoclonal antibodies. antibodies associated trastuzumab,...
The aim of the study was to estimate diagnostic accuracy textural features extracted by dual-energy contrast-enhanced mammography (CEM) images, carrying out univariate and multivariate statistical analyses including artificial intelligence approaches. In total, 80 patients with known breast lesion were enrolled in this prospective according regulations issued local Institutional Review Board. All underwent CEM examination both craniocaudally (CC) double acquisition mediolateral oblique (MLO)...
CD4 + FOXP3 regulatory T cells (T regs ) suppress immune responses to tumors, and their accumulation in the tumor microenvironment (TME) correlates with poor clinical outcome several cancers, including breast cancer (BC). However, properties of intratumoral remain largely unknown. Here, we found that a functionally distinct subpopulation , expressing Exon2 splicing variants, is prominent patients hormone receptor–positive BC prognosis. Notably, comprehensive examination TCGA validated...
Introduction In 2018, the National Cancer Institute of Naples has launched GLUBREAST Trial to verify efficacy cyanoacrylate sealing glue prevent or reduce seroma after axillary dissection in breast surgery. The is a synthetic sealant (N-Butyl-2-CyanoAcrylate+Metacryloxisulfolane) biocompatible, CE approved for internal human uses and surgical procedures. assumed mechanism action surgery that would create seal coating operative field occlude lymphatic leaks limit formation. Materials methods...
Benefits from laparoscopic colorectal surgery have been widely demonstrated.A steep learning curve is considered the main limitation to its adoption.We present short-term outcomes in a prospective series.A modular, stepwise approach leads excellent results.Even trainees can safely learn both and open surgery, when strictly supervised.
Metabolic Syndrome (MS) has been correlated to breast carcinogenesis. MS is common in the general population (34%) and increases with age body mass index. Although link between obesity, hormone related cancer incidence now widely recognized, molecular mechanisms at basis of such increase are still poorly characterized. A crucial role supposed be played by altered insulin signalling, occurring obese patients, which fuels cell growth, proliferation survival. Therefore we focused specifically...
The aim of the present study was to assess quercetin's mechanism action in rat pial microvessels during transient bilateral common carotid artery occlusion (BCCAO) and reperfusion. Rat microcirculation visualized using fluorescence microscopy through a closed cranial window. Pial arterioles were classified five orders branchings. In ischemic rats, 30 min BCCAO 60 reperfusion caused arteriolar diameter decrease, microvascular leakage, leukocyte adhesion venules reduction capillary perfusion....
Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. The aim of this study was evaluate the inositol and alpha lipoic acid combination effectiveness syndrome features in postmenopausal women at risk breast cancer. A six-month prospective, randomized placebo-controlled trial carried out total 155 affected by cancer, INOSIDEX trial. All were asked follow low-calorie diet assigned randomly daily...
The incidence and number of deaths caused by pancreatic tumours have been gradually rising, while the mortality other common cancers declining. Risk factors for this malignant disease include cigarette smoking, family history chronic pancreatitis, advancing age, male sex, diabetes mellitus, obesity, non-0 blood group, a high-fat diet, alcohol consumption possibly Helicobacter pylori hepatitis B virus infections. Metabolic diseases become leading cause death in many countries. Our paper...
Metabolic syndrome (MS) has been shown to increase the risk of breast cancer. Existing data suggest that strength metabolic syndrome-breast cancer link varies by intrinsic molecular subtype, but results from worldwide literature are controversial. Primary endpoint study was assess whether MS is a predictor specific (BC) subtype. Secondary determine components can individually subtype.Anthropometric and variables were correlated subgroups, retrospectively. Statistical significance considered...
Functional disorders of the biliary tract involve gallbladder and sphincter Oddi cause pain and/or digestive troubles. In this context, in addition to pharmacological treatments, an important role is played by use sodium-sulphate sulphate-bicarbonate mineral waters that, because their composition into ions macro trace elements, can stimulate release or modulate activity some neurohumoral regulators process. We want do a study on effects hydropinotherapy with...
Hyperglycemia and hyperinsulinemia may play a role in breast carcinogenesis prediabetes diabetes have been associated with increased cancer (BC) risk. However, whether BC molecular subtypes modify these associations is less clear. We therefore investigated all cases by among women living Southern Italy. Cases were 557 patients non‐metastatic incident controls 592 outpatients enrolled during the same period as hospital for skin‐related non‐malignant conditions. Adjusted multivariate logistic...
Abstract Background Fibroadenomas are the second most common breast pathology occurring in young women under age of 35 years old. can be classified as simple or complex according to histological features. Complex fibroadenomas differ from because presence cysts (3 mm), sclerosing adenosis, epithelial calcifications, papillary apocrine changes. Most clinically identifiable. In 25% cases, non-palpable and diagnosed with mammography ultrasound. Differential diagnosis well differentiated cancer...
Purpose: In the last decade contrast-enhanced magnetic resonance imaging (MRI) has gained a growing role as complementary tool for breast cancer diagnosis. Currently relationship between kinetic features of lesion and pathologic prognostic factors become popular field research. Our aim is to verify whether MRI could be considered useful predict Ki-67 score, thus resulting prognosis indicator. Methods: From June December 2014, we enrolled patients with who underwent preoperative dynamic at...