A5105514327- HIV Research and Treatment
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Herpesvirus Infections and Treatments
- Immune Cell Function and Interaction
- Virology and Viral Diseases
- Endoplasmic Reticulum Stress and Disease
- Viral Infections and Immunology Research
- Herbal Medicine Research Studies
- vaccines and immunoinformatics approaches
- Social Media and Politics
- Complementary and Alternative Medicine Studies
- Vaccine Coverage and Hesitancy
- Therapeutic Uses of Natural Elements
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Pandemic Impacts
- Thyroid and Parathyroid Surgery
- Alcohol Consumption and Health Effects
- Cytomegalovirus and herpesvirus research
- Combustion and flame dynamics
- Statistical Methods and Bayesian Inference
- Aerosol Filtration and Electrostatic Precipitation
Istituto Superiore di Sanità
1998-2022
European Commission
2014-2021
Medicines Evaluation Unit
2014
Mount Sinai Hospital
1998
University of Padua
1993
University of Toledo Medical Center
1973
ProMedica Toledo Hospital
1973
Objective: To assess gender differences in the long-term clinical, virological and immunological outcomes during highly active antiretroviral therapy (HAART). Methods: This longitudinal observational multicentre study followed 2460 HIV-infected patients who had begun a protease inhibitor-based regimen for median period of 43 months. Outcome measures were suppression (< 500 copies/ml), confirmed rebound after suppression, death or new AIDS-defining illness (ADI). Results: At baseline, 690...
Abstract The duration of the clinical, virologic, and immunologic response to HAART, is not well defined. In this observational multi‐center study 2,143 patients were enrolled classified according virologic suppression (<500 cp/ml) immune recovery (>100 CD4+ cells/μl from baseline) at month 12 HAART as complete responders, only responders non‐responders. Kaplan Meyer curves, multivariate politomous regression analysis used. Complete 781 (36.4%), 441 (20.6%), 336 (15.7%), non‐responders...
The ability of a live attenuated simian immunodeficiency virus (SIV) to protect against challenge with cloned SIVmac251/BK28 was evaluated in four cynomolgus macaques. intravenous infection the C8 variant SIVmac251/32H virus, carrying an in-frame 12 bp deletion nef gene, did not affect CD4 and CD8 cell counts, persistent associated extremely low burden peripheral blood mononuclear cells (PBMCs) established. After 40 weeks, these monkeys were challenged intravenously 50 MID50 dose grown on...
In Italy most herbal products are sold as food supplements and subject only to law. A list of about 1200 plants authorised for use in has been compiled by the Italian Ministry Health. order review possibly improve Ministry's an ad hoc working group Istituto Superiore di Sanità was requested provide a technical scientific opinion on plant safety. The listed were evaluated basis their food, therapeutic activity, human toxicity no-alimentary fields. Toxicity also assessed limitations defined.
Functional disorders of the biliary tract involve gallbladder and sphincter Oddi cause pain and/or digestive troubles. In this context, in addition to pharmacological treatments, an important role is played by use sodium-sulphate sulphate-bicarbonate mineral waters that, because their composition into ions macro trace elements, can stimulate release or modulate activity some neurohumoral regulators process. We want do a study on effects hydropinotherapy with...
Background. Cancer patients are among the main consumers of traditional, complementary, integrative, and alternative medicine (TCIM) such as natural products (herbals, integrators, etc.) mind body practices (yoga, acupuncture, etc.). Methods. A questionnaire on TCIM was submitted to 415 Italian cancer patients. The consisted three sections: (i) biographical clinical information; (ii) use substances; (iii) mind-body practices. Results. 406 completed questionnaire. prevalence 72.3%. Of them,...
The E1 glycoprotein of hepatitis C virus is a transmembrane with C-terminal anchor domain. When expressed in Escherichia coli, induces change membrane permeability that toxic to the bacterial cell. hydrophobic region (aa 331-383) mainly responsible for association and inducing changes permeability. These observed are similar those produced E. coli by influenza M2, human immunodeficiency gp41 poliovirus 3AB proteins, whose domains thought cause pore formation biological membranes. To further...
ABSTRACT The infection of CD4-negative cells by variants tissue culture-adapted human immunodeficiency virus type 1 (HIV-1) or HIV-2 strains has been shown to be mediated the CXCR4 coreceptor. Here we show that two in vitro-established CD4 − /CCR5 /CXCR4 + pre-T-cell lines (A3 and A5) can productively infected wild-type laboratory-adapted T-cell-tropic HIV-1 a CD4-independent, CXCR4-dependent fashion. Despite absence CCR5 expression, A3 A5 were susceptible simian viruses SIVmac239 SIVmac316....
We study a simple exogeneity test in count data models with possibly endogenous multinomial treatment. The is based on Two Stage Residual Inclusion (2SRI). Results from broad Monte Carlo provide novel evidence important features of this approach nonlinear settings. find differences the finite sample performance various likelihood-based tests under correct specification and when outcome equation misspecified due to neglected over-dispersion or non-linearity. compare alternative 2SRI...
In cynomolgus monkeys, we compared two human‐derived SIV mac 251 whole virus vaccines, a long vs short immunization schedule, and different challenge viruses. Both vaccines induced protection after with 251/32H. There was no difference between the schedules of immunization. Seven five which were protected following first challenge, reboosted rechallenged monkey‐derived 251, but observed. The titers anti‐human cell or ‐SIV neutralizing antibodies not related to protection.
Abstract Simian immunodeficiency virus (SIV) as well human (HIV) induce polyclonal B‐cell activation and are associated with the appearance of lymphomas in their respective hosts either presence or absence other co‐infecting viruses such Epstein‐Barr (EBV). However, pathogenic role these retroviruses development lymphoproliferative disorders remains poorly understood. To explore virus–B‐cell interactions, two immortalized lymphoblastoid lines (SL‐P1 SL‐691) were established from cynomolgus...
To assess the reliability of spontaneous in vitro synthesis simian immunodeficiency virus (SIV)-specific antibodies as a marker monitoring protection SIV-vaccinated animals, Macaca fascicularis monkeys were immunized with formalin-inactivated SIVmac251 or SIVmac251/32H, and challenged human-derived (SIVmac251/32H) monkey-derived live SIV. As judged by isolation polymerase chain reaction (PCR) techniques, animals protected against SIV challenge, no anti-SIV antibody was observed nonstimulated...
Five pregnant (two to three and one-half months) Macaca fascicularis seroconverted following immunization with sucrose-gradient purified formalin-inactivated whole simian immunodeficiency virus (SIVmac251). No untoward effects on fetal maturation were observed during the of mothers. Antibodies SIVmac251 (also those in vitro neutralizing activity) passively transferred offspring but disappeared within two six months after birth. env glycoprotein (gp130) lasted longer than against viral gag...
The potential therapeutic utility of thalidomide (Thd), an effective inhibitor tumor necrosis factor (TNF)‐α in vitro , was investigated cynomolgus monkeys ( Macaca fascicularis ) at 10 months after infection with simian immunodeficiency virus (SIV). Thd‐treated macaques (n=8) received oral dose (10 mg) daily for 7 days, followed by a wash‐out period 5 weeks. A 2nd cycle treatment performed on the same animals higher doses (20 mg Thd/day) 14 days. control (n=7) placebo time. In present...