A5107963810- Cutaneous Melanoma Detection and Management
- Breast Cancer Treatment Studies
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Breast Lesions and Carcinomas
- Melanoma and MAPK Pathways
- Optical Coherence Tomography Applications
- Advanced Biosensing Techniques and Applications
- Global Cancer Incidence and Screening
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Cell Image Analysis Techniques
- BRCA gene mutations in cancer
- Histone Deacetylase Inhibitors Research
- Mast cells and histamine
- Protist diversity and phylogeny
- Cancer Research and Treatments
- Vascular Tumors and Angiosarcomas
- Estrogen and related hormone effects
- Economic and Financial Impacts of Cancer
- Body Contouring and Surgery
- Nutrition and Health in Aging
- Dermatologic Treatments and Research
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
1998-2025
Indiana University Indianapolis
2005
University of Kentucky
2005
Indiana University – Purdue University Indianapolis
2005
University of Sassari
2003
National Research Council
2003
Tumour Institute of Tuscany
2000-2002
ANT Foundation Italy Onlus
2000
Purpose Individuals with metastatic melanoma have a poor prognosis. Many human melanomas are auxotrophic for arginine, and arginine is not an essential amino acid in humans. We hypothesized that this auxotrophy may be therapeutically exploited. A novel acid–degrading enzyme (arginine deiminase) conjugated to polyethylene glycol (ADI-SS PEG 20,000 mw) was used lower plasma individuals melanoma. Patients Methods Two cohort dose-escalation studies were performed. phase I study the United States...
Introduction In 2018, the National Cancer Institute of Naples has launched GLUBREAST Trial to verify efficacy cyanoacrylate sealing glue prevent or reduce seroma after axillary dissection in breast surgery. The is a synthetic sealant (N-Butyl-2-CyanoAcrylate+Metacryloxisulfolane) biocompatible, CE approved for internal human uses and surgical procedures. assumed mechanism action surgery that would create seal coating operative field occlude lymphatic leaks limit formation. Materials methods...
To evaluate the role of epiluminescence microscopy (ELM) in differential diagnosis cutaneous pigmented lesions, and to improve early malignant melanoma (CMM), 15,719 lesions from 8782 consecutive patients were evaluated using ELM with a hand-held video microscope imaging system (MS 500B Micro-Scopeman, Moritex). Comparison between risk levels as inferred screening histology was performed on 2731 surgically excised lesions. sensitivity, specificity, positive negative predictive values, well...
BACKGROUND In a previous study, the authors tested combination of fotemustine (FM) 100 mg/m2 intravenously (i.v.) on Day 1, dacarbazine (DTIC) 250 i.v. Days 2–5, and interferon α (IFNα) 3 MIU intramuscularly three times per week in 43 patients with advanced melanoma. An overall response rate 40% median survival 40 weeks were obtained. To evaluate whether addition cisplatin (CDDP) to this regimen could improve these results, conducted preliminary Phase I study concluded that CDDP 25 for 2...
Epiluminescence microscopy (ELM) strongly improves the separation of different types cutaneous pigmented lesions (CPL) and facilitates early diagnosis melanoma (CM). ELM alone is not 100% accurate in routine diagnosis, should be considered only criterion high-risk skin lesions. We have however, demonstrated close agreement between classification criteria histology 2,731 In past five years, our Melanoma Cooperative Group has evaluated 61,000 from 30,000 individuals identified 478 melanomas....
BACKGROUND Interferon (IFN) is widely considered the most effective agent in adjuvant therapy of patients with cutaneous melanoma (CM). However, little known about effect IFN on pretreated CM who experience disease recurrence. The authors conducted a Phase II study to determine whether intermediate doses could be beneficial for these patients. METHODS A series 24 consecutive had undergone surgery local, in-transit, or lymph node recurrence during low dose (IFNα-2b, 3 million units [MU] per...
Here we report a case of 50-mm lump within the left breast in 56-year-old man. The patient underwent total mastectomy and sentinel node biopsy. pathology showed low-grade intracystic papillary carcinoma surrounded by ductal situ. Sentinel biopsy was negative. prescribed five years tamoxifen.
BACKGROUND In a previous study, the authors tested combination of fotemustine (FM) 100 mg/m2 intravenously (i.v.) on Day 1, dacarbazine (DTIC) 250 i.v. Days 2–5, and interferon α (IFNα) 3 MIU intramuscularly three times per week in 43 patients with advanced melanoma. An overall response rate 40% median survival 40 weeks were obtained. To evaluate whether addition cisplatin (CDDP) to this regimen could improve these results, conducted preliminary Phase I study concluded that CDDP 25 for 2...
Non-Hodgkin lymphoma (NHL) of the breast is a rare disease and can occur amongst patients affected by Waldenström's Macroglobulinemia (WM). WM an indolent B-cell lymphoproliferative disorder with overall incidence about 1/100,000 in Europe. Breast imaging not specific to that often mimics benign lesions. The diagnosis based on biopsy, presence MYD88L265P somatic mutation immunoglobulin M (IgM) paraprotein detectable setting lymphoplasmacytic infiltration bone marrow (BM) biopsy.A 60-year-old...