A5028548219- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Functional Brain Connectivity Studies
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Autoimmune Neurological Disorders and Treatments
- Genetics and Neurodevelopmental Disorders
- Neural dynamics and brain function
- Metabolism and Genetic Disorders
- Tuberous Sclerosis Complex Research
- Neurofibromatosis and Schwannoma Cases
- Neuroscience and Neural Engineering
- Frailty in Older Adults
- Ophthalmology and Eye Disorders
- Sleep and related disorders
- Ocular Diseases and Behçet’s Syndrome
- Mental Health and Psychiatry
- Cerebral Venous Sinus Thrombosis
- Polyomavirus and related diseases
- Psychosomatic Disorders and Their Treatments
- Epigenetics and DNA Methylation
- Paranormal Experiences and Beliefs
Sapienza University of Rome
2020-2025
Policlinico Umberto I
2021-2022
Abstract Objective Due to the high clinical heterogeneity of epilepsy, there is a critical need for novel metrics aimed at capturing its biological and phenotypic complexity. Frailty increasingly recognized in various medical disciplines as useful construct understand differences susceptibility adverse outcomes. Here, we develop frailty index (FI) patients with epilepsy (PwE) explore association demographic features. Methods In this cross‐sectional study, consecutively enrolled 153 PwE from...
Objective To investigate the electroclinical characteristics and prognostic impact of generalized fast discharges in a large cohort genetic epilepsy (GGE) patients studied with 24-h prolonged ambulatory electroencephalography (paEEG). Methods This retrospective multicenter study included 202 GGE patients. The occurrence paroxysmal activity (GPFA) polyspike train (GPT) was reviewed. were classified as having idiopathic (IGE) or another syndrome (namely perioral myoclonia absences, eyelid...
The involvement of epigenetics mechanisms in the transcriptional regulation key genes has been investigated initiation and progression neurodegenerative disorders, including Parkinson's disease (PD). Among others, we, here, focused attention on dopamine transporter (DAT) gene playing a critical role maintaining integrity dopaminergic neurons.We performed bisulfite pyrosequencing to examine DNA methylation levels six CpG sites 5'-UTR DAT1 human peripheral blood mononuclear cells (PBMCs)...
To investigate the temporal course of medication response and associated prognostic factors in a cohort juvenile myoclonic epilepsy (JME) patients over long-term follow-up.Data from 113 JME diagnosed according to recently proposed class II criteria were retrospectively reviewed. Early sustained remission was defined as 4-year seizure starting within 2 years first antiseizure (ASM) intake, opposed delayed remission. Spontaneous relapse rate (ie, not related ASM withdrawal) also investigated,...
Patients with amnesic mild cognitive impairment due to Alzheimer's disease (ADMCI) typically show a "slowing" of cortical resting-state eyes-closed electroencephalographic (rsEEG) rhythms. Some them also subclinical, non-convulsive, and epileptiform EEG activity (EEA) an unclear relationship that "slowing."Here we tested the hypothesis rsEEG rhythms is related EEA in ADMCI patients.Clinical instrumental datasets 62 patients 38 normal elderly (Nold) subjects were available national archive....
Different pathophysiologic mechanisms, especially involving astrocytes, could contribute to tuberous sclerosis complex (TSC). We assessed neurodegeneration and astrocytopathy plasma biomarkers in adult patients with TSC define biomarker profile investigate clinical-radiologic correlations.
Late-onset epilepsy (LOE) has recently become a topic of intense research. Besides stroke, tumors, and dementia, autoimmune encephalitis (AE) emerged as another possible cause recurrent seizures in the elderly, may account for proportion cases LOE unknown origin (LOEUO). This 24-h ambulatory electroencephalography (AEEG)-based study compared patients with LOEUO AE to identify features suggestive immune-mediated elderly.We retrospectively reviewed 232 AEEG examinations performed over 55 years...
Objectives To investigate the aetiology of acute-onset binocular diplopia (AOBD) in neurological units and identify key diagnostic procedures this setting. Materials methods Clinico-demographic data from patients hospitalized for AOBD 2008 to 2019 were retrospectively reviewed. due an underlying disorder known cause was addressed as secondary diplopia. Ophthalmoparesis plus defined when subtle signs/symptoms other than ophthalmoparesis detected during examination. Results A total 171 (mean...
Selective sodium channel blockers (SSCBs) have a limited use in genetic generalized epilepsy (GGE), due to their well-known risk of seizure worsening. Although therapeutic potential GGE has been suggested by recent evidence, electro-clinical data supporting prescription are lacking. We aimed investigate SSCB safety and effectiveness cohort.Subjects who received SSCBs had ≥5-year follow-up were enrolled. Lamotrigine was excluded from analysis its broader pharmacodynamic spectrum...
Abstract Background Vigilance and sleep disturbances in Alzheimer’s related diseases, even at the stage of mild cognitive impairment (MCI), have been extensively documented, showing abnormal daytime naps alterations sleep‐wake cycle. However, EEG correlates transition from wakefulness to light not yet compared between MCI patients due vs. other neurodegenerative diseases. Therefore, it is unclear whether there are specific features these disease (AD) patients. This issue was investigated...
Abstract Background Alzheimer’s Disease (AD) and Sleep disturbances are closely linked in a bidirectional relationship. Indeed, sleep alterations represent precipitating factor early pathogenesis of neurodegeneration. Conversely, the accumulation Aβ tau proteins directly disrupts sleep‐wake cycles. extremely prevalent AD relationship between these disorders has been thoroughly investigated. Our study is first to investigate electroencephalographic cortical sources during transitional stages...
Abstract Background Huntington’s disease (HD) is a progressive neurodegenerative disorder phenotypically manifested by motor, cognitive and psychiatric symptoms (Novak Tabrizi, 2011). These patients are also characterized vigilance abnormalities. This has been demonstrated electrophysiological measures (Wiegand et al., 1991). In particular, previous studies have shown that HD reduced alpha amplitude (de Tommaso 2003; Bellotti 2004) increased resting delta activity (Bylsma 1994)....
Abstract Background Alzheimer’s Disease (AD) patients present a higher risk of developing epilepsy compared to the age‐matched general population. Neurodegenerative cognitive disorders in are closely linked with and subclinical Epileptiform Electroencephalographic Activity (EEA). Furthermore, AD Mild Cognitive Impairment (MCI) abnormalities posterior cortical sources resting‐state eyes‐closed EEG rhythms at delta (< 4 Hz) low‐frequency alpha (8‐10 rhythms. This retrospective study tested...