A5023433864- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Endodontics and Root Canal Treatments
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Advanced Nanomaterials in Catalysis
- Cancer Mechanisms and Therapy
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Liver Disease and Transplantation
- Dental Radiography and Imaging
- Metal-Organic Frameworks: Synthesis and Applications
- Oral and Maxillofacial Pathology
- Dental materials and restorations
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Industrial Vision Systems and Defect Detection
- Nerve injury and regeneration
- Hearing, Cochlea, Tinnitus, Genetics
Jiamusi University
2009-2025
Model Animal Research Center
2022-2025
Nanjing Drum Tower Hospital
2022-2025
Nanjing University
2024-2025
Shenyang Agricultural University
2011-2024
Second Affiliated Hospital of Jilin University
2010-2024
Beijing YouAn Hospital
2014-2024
Capital Medical University
2014-2024
First Affiliated Hospital of Kunming Medical University
2019-2024
Kunming Medical University
2019-2024
Ferroptosis is a newly discovered form of non-apoptotic cell death in multiple human diseases.However, the epigenetic mechanisms underlying ferroptosis remain poorly defined.First, we demonstrated that lymphoid-specific helicase (LSH), which DNA methylation modifier, interacted with WDR76 to inhibit by activating lipid metabolism-associated genes, including GLUT1, and related genes SCD1 FADS2, turn, involved Warburg effect.WDR76 targeted these expression dependent manner LSH chromatin...
Aging is a multifactorial process characterized by the progressive deterioration of physiological functions. Among multiple molecular mechanisms, microRNAs (miRNAs) have increasingly been implicated in regulation process. However, contribution miRNAs to and underlying mechanisms remain elusive. We herein performed high-throughput analysis using miRNA mRNA microarray mouse, attempted deepen into understanding effects on at "network" level. The data showed that various p53 responsive miRNAs,...
DNA methyltransferases (DNMTs) catalyze methylation, and their functions in mammalian embryonic development diseases including cancer have been extensively studied. However, regulation of DNMTs remains under study. Here, we show that CCAAT/enhancer binding protein α (CEBPA) interacts with the long splice isoform DNMT3A, but not short DNMT3A2. CEBPA, by interacting DNMT3A N-terminus, blocks from accessing substrate thereby inhibits its activity. Recurrent tumor-associated CEBPA mutations,...
ARHGEF6 belongs to the family of guanine nucleotide exchange factors (GEFs) for Rho GTPases, and it specifically activates GTPases CDC42 RAC1. Arhgef6 is X-linked intellectual disability gene also known as XLID46, clinical features patients carrying mutations include and, in some cases, sensorineural hearing loss. act molecular switches many cellular processes. Their activities are regulated by binding or hydrolysis GTP, which facilitated GTPase-activating proteins, respectively. RAC1 have...
Abstract The 69th World Health Assembly endorsed the Global Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as public health threat by 2030. This was followed Organization's (WHO) global targets care and management of B virus (HBV) C (HCV) infections. These announcements were important in raising awareness calling action; however, tracking countries’ progress towards these elimination goals has provided insights limitations targets. existing compare...
Objective The present study aims to investigate the specific protective effects and underlying mechanisms of Ganshuang granule (GSG) on dimethylnitrosamine (DMN)-induced hepatic fibrosis in rat models. Methods Hepatic was experimentally evoked rats by DMN administration, varying dosages GSG were employed as an intervention. Hepatocellular damage assessed measuring serum levels aminotransferase bilirubin, accompanied histopathological examinations tissue. concentrations platelet-derived...
A copper-based nanoenzyme (Cu-BL) co-modified by L-L-lysine and 2-2-amino terephthalic acid has laccase-like activity fluorescence characteristics. Based on this, a colorimetric fluorescent dual-mode sensor was developed to visually quantitatively detect tetracycline antibiotics (TCs), including (TC), chlortetracycline (CTC), oxytetracycline (OTC). In the detection system, TCs can inhibit generation of singlet oxygen (1O2) weaken ability 2,4-dichlorophenol (2,4-DP) be oxidized into...
Overexpression of human pituitary tumor transforming gene (PTTG) is wildly detected in many tumors, including esophageal cancer. Besides overexpression PTTG squamous cell carcinoma (ESCC) tissues and cells, we accumulation cytoplasmic beta-catenin ESCC. In our study, a putative TCF4-binding element (TBE) was identified promoter region. The activity containing the TBE activated by S37Abeta-catenin inhibited dominant-negative TCF. Furthermore, activation mostly abrogated among region without...
// Weiwei Lai 1, 2 , Jiantao Jia 2, 4 Bin Yan Yiqun Jiang Ying Shi Ling Chen Chao Mao Xiaoli Liu Haosheng Tang 3 Menghui Gao Ya Cao Shuang 5 and Yongguang Tao 1 Key Laboratory of Carcinogenesis Cancer Invasion, Ministry Education, Xiangya Hospital, Central South University, Changsha, Hunan, China Research Institute, Department Thoracic Surgery, Second Changzhi Medical College, Changzhi, Shanxi, Institute Sciences, Correspondence to: Tao, email: taoyong@csu.edu.cn Keywords: baicalin hydrate;...
Histones methyltransferase NSD3 targeting H3K36 is frequently disordered and mutant in various cancers, while the function of during cancer initiation progression remains unclear. In this study, it proved that downregulated level linked to clinical features poor survival lung adenocarcinoma. vivo, inhibited proliferation, immigration, invasion ability Meanwhile, suppressed glycolysis by inhibiting HK2 translation, transcription, glucose uptake, lactate production Mechanistically, as an...
Cell invasion is crucial for high mortality and recurrence rate in glioma. Epithelial-mesenchymal transition (EMT) an important step cancer invasion. Metadherin (MTDH) contributes to EMT several cancers, but the role mechanism of MTDH EMT-like process glioma remain unknown. Here we demonstrate that was overexpressed tissues cells induced change cells. Interestingly, could modulate expression a group glioma-related miRNAs. In particular, upregulated miR-130b transcription via acting as...
Long noncoding RNAs (lncRNAs) have emerged as critical regulators for gene expression in multiple levels and thus are involved various physiological pathological processes. Sirtuin 1 (SIRT1) has been established to exert key roles the diverse biological process through deacetylation of substrates, including DNA damage repair. Nevertheless, regulatory relationship between SIRT1 lncRNAs, effect lncRNA on SIRT1-mediated functions were still far be elucidated. We herein uncovered that miR17HG...
Multiple idiopathic external cervical root resorption is a rare condition with numerous predisposing factors that have not yet been clearly elucidated. In addition, its diagnosis and treatment pose challenges for clinicians, thus, the extraction of involved teeth commonly performed. Here, we report 29-year-old pregnant woman no contributory medical or family/social history who experienced progressed aggressively all permanent teeth. This case unique owing to involvement Reports multiple are...
Our study seeks to obtain data which help assess the impacts and related mechanisms of microRNA miR-509-3p in hepatocellular carcinoma (HCC). We found that expression was down-regulated Twist up-regulated HCC tissues cell lines (HepG2, HCCLM3, Bel7402, SMMC7721) compared with adjacent normal human hepatocyte (L02). Moreover, proliferation, invasion, migration epithelial–mesenchymal transition (EMT) HepG2 HCCLM3 cells were appeared be markedly suppressed by overexpressed miR-509-3p....
Abstract Spermatogenesis is a complex process related to male infertility. Till now, the critical genes and specific mechanisms have not been elucidated clearly. Our objective was determine hub that play crucial role in spermatogenesis by analyzing differentially expressed (DEGs) present non-obstructive azoospermia (NOA) compared OA normal samples using bioinformatics analysis. Four datasets, namely GSE45885, GSE45887, GSE9210 GSE145467 were used. Functional enrichment analyses performed on...
The content of active compounds differ in buds and flowers Lonicera japonica (FLJ) L. var. chinensis (rFLJ). Chlorogenic acid were major regarded as measurements for quality evaluation. However, little is known concerning the formation at molecular level. We quantified chlorogenic (CGAs) FLJ rFLJ, found concentrations CGAs higher rFLJ than those FLJ. Further analysis CpG methylation biosynthesis genes showed differences between 5′-UTR phenylalanine ammonia-lyase 2 (PAL2). identified 11...
Cerebral palsy (CP) is a severe type of brain disease affecting movement and posture. Although CP has strong genetic environmental components, considerable differences in the methylome between monozygotic (MZ) twins discordant for implicates epigenetic contributors as well. In order to determine methylation patients with without interference interindividual genomic variation, four pairs MZ were profiled DNA changes using reduced representation bisulfite sequencing on genomic‑scale. Similar...
Aims: To investigate if DNA methylation pattern assay could be a new approach to identifying the primary tumor cell origin of recurrent hepatocellular carcinoma (HCC). Materials & Methods: Methylation 24 genes and expression 22 cancer stem (CSC) biomarkers were quantitatively measured in 10 paired HCC specimens. The HBV viral–host junctions determined six pairs them with infection. Results: Similar patterns observed among nine ten tumors. In five specimens infection, exactly same...
To evaluate the progression of fibrosis and factors influencing this in interferon (IFN) treatment-naive Chinese plasma donors infected with hepatitis C virus (HCV) for approximately 20 years.From July 2010 to June 2011, we investigated 122 IFN chronic (CHC) patients by donation 1992-1995. Liver stage inflammation grade were evaluated Metavir Scheuer scoring systems, respectively.One hundred twenty underwent liver biopsy. biopsy was not performed one patient cirrhosis due ascites, another...