A5030407890- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer Cells and Metastasis
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Chemokine receptors and signaling
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Diet and metabolism studies
- Gut microbiota and health
- Biochemical Analysis and Sensing Techniques
- Lung Cancer Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Cancer Immunotherapy and Biomarkers
- Extracellular vesicles in disease
- Advanced Chemical Sensor Technologies
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Neuroblastoma Research and Treatments
- Peptidase Inhibition and Analysis
- Culinary Culture and Tourism
Nanjing Drum Tower Hospital
2021-2025
Model Animal Research Center
2025
Nanjing University
2025
Nanjing University of Chinese Medicine
2024
Qinghai University Affiliated Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Ninth People's Hospital
2024
Capital Medical University
2024
Kyushu University
2016-2018
Kyoto University
2018
Abstract Objectives Bladder carcinoma (BC) is a common malignancy of the urinary tract. As new hallmark cancer for drug therapy, RNA-binding proteins (RBPs) are key regulatory factors in alternative splicing events. This work to uncover relationship between BC and RBP order find targets BC. Methods In this work, data from single-cell RNA-seq GSE1355337, PRJNA662018, TCGA-Bladder urothelial (BLCA) cohorts integrated identify their relationships. A scoring system constructed according RBPs...
Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of cancer, which ranks as first malignant tumor in mortality. The occurrence and development NSCLC are closely related to microenvironment (TME). Cancer-associated fibroblasts (CAFs) considered be critical regulators NSCLC, have essential effects on multiple biological characteristics NSCLC. hallmarks biology been updated recently, however, there no reviews revisiting function CAFs microenvironment. This article origin,...
AIM: To study the effects of perioperative administration cimetidine (CIM) on peripheral blood lymphocytes, natural killer (NK) cells and tumor infiltrating lymphocytes (TIL) in patients with gastrointestinal (GI) cancer. METHODS: Forty-nine GI cancer were randomized into treatment group, who took CIM period, control did not take drug. The was initiated 7 days before operation continued for 10 after surgery. At baseline examination operation, 2nd 10th postoperative days, total T helper...
Background: Maintenance therapy could significantly improve the prognosis of patients with advanced non-small cell lung cancer (NSCLC) receiving chemotherapy. Anlotinib is effective, tolerable, and convenient in administration as a third-line treatment for NSCLC. This study aimed to evaluate efficacy safety maintenance anlotinib after platinum-based induction chemotherapy Methods: pooled analysis 2 multicenter, open-label, single-arm, phase clinical trials (ALTER-L014 ALTER-L011) enrolled...
FEAT is an intracellular protein that potently drives tumorigenesis in vivo. It only weakly expressed normal human tissues, including the testis. In contrast, aberrantly upregulated most cancers. The present study was designed to investigate whether applicable tumor immunotherapy and discernible bloodstream as a molecular biomarker of cancers.Two mouse peptides with predicted affinities for major histocompatibility complex H-2Kb H-2Db were injected subcutaneously into C57BL/6 mice before...
Abstract FEAT, the protein encoded by methyltransferase‐like 13 ( METTL13 ), is aberrantly upregulated in most human cancers and potently drives tumorigenesis vivo; however, its role normal tissues remains elusive. Immunoblotting has displayed weak FEAT expression tissues, including testis. Here, we found that expressed fetal adult Leydig cells knockdown using siRNA increased primary cilia formation MA‐10 tumor cells, accompanied enhanced 5′ adenosine monophosphate‐activated kinase (AMPK)...
Abstract Background It has been proposed that anti-angiogenesis therapy could induce tumor "vascular normalization" and further enhance the efficacy of chemotherapy, radiotherapy, target therapy, immunotherapy for nearly twenty years. However, detailed molecular mechanism this phenomenon is still obscure. Method Overexpression knockout CCL28 in human lung adenocarcinoma cell line A549 murine LLC, respectively, were utilized to establish mouse models. Single-cell sequencing was performed...
Abstract Bladder cancer (BC) is the tenth most common tumor worldwide, characterized by high incidence rates and mortality. This study aimed to explore role of Methyltransferase like 13 (METTL13) in BC cells. J82 T24 cells were cultured for vitro experiments. Cell viability, migration, invasion assessed using CCK-8 transwell assays. Senescence-associated beta-galactosidase (SA-β-gal) levels detected a β-galactosidase staining kit. METTL13 cell cycle-related protein quantified RT-qPCR Western...