A5044739137- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- RNA modifications and cancer
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Helicobacter pylori-related gastroenterology studies
- Power Quality and Harmonics
- Cancer, Lipids, and Metabolism
- Microtubule and mitosis dynamics
- Wnt/β-catenin signaling in development and cancer
- Metabolism, Diabetes, and Cancer
- Cancer Treatment and Pharmacology
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Caveolin-1 and cellular processes
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
Nanjing University
2016-2025
Nanjing General Hospital of Nanjing Military Command
2016-2025
Nanjing Medical University
2015-2025
Shandong University of Technology
2010-2020
Karolinska Institutet
2016-2017
Sichuan University
2013
West China Hospital of Sichuan University
2013
Indiana University School of Medicine
2013
Zen-Noh (Japan)
2005
Fibroblasts in the tumor stroma are well recognized as having an indispensable role carcinogenesis, including initiation of epithelial formation. The association between cancer cells and fibroblasts has been highlighted several previous studies. Regulation factors released from cancer‑associated (CAFs) into microenvironment have essential roles, support growth, angiogenesis, metastasis therapy resistance. A mutual interaction tumor‑induced fibroblast activation, fibroblast‑induced...
Abstract Cancer-associated fibroblasts (CAF) are recognized as one of the key determinants in malignant progression lung adenocarcinoma. And its contributions to chemoresistance acquisition cancer has raised more and attention. In our study, associated treated with cisplatin conferred cells. Meanwhile, Interleukin-11(IL-11) was significantly up-regulated CAF stimulated by cisplatin. As confirmed adenocarcinoma cells vivo vitro , IL-11 could protect from cisplatin-induced apoptosis thus...
Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in malignant transformation. We investigated the clinical significance miR-650 and its involvement chemoresistance to docetaxel. Our results showed relative expression level was significantly higher LAD tissues than corresponding nontumor high found be associated with incidence lymph node metastasis, advanced stage poor prognosis patients. Univariate multivariate analyses indicated an independent prognostic factor...
// Banzhou Pan 1 , Bing Feng Yitian Chen Guichun Huang Rui Wang Longbang 1, * Haizhu Song Department of Medical Oncology, Jinling Hospital, School Medicine, Nanjing University, 210002, China These authors have contributed equally to this work Correspondence to: Song, e-mail: songhaizhu@163.com Keywords: miR-200b, autophagy, chemoresistance, human lung adenocarcinoma, ATG12 Received: April 12, 2015 Accepted: September 10, Published: 21, 2015 ABSTRACT...
Abstract Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer ECA109 Kyse150. We then found activity was higher further activated upon ionizing radiation (IR) exposure. In addition, acquired epithelial-to-mesenchymal transition (EMT) properties stem quality. to be radioresistance by promoting DNA damage repair. our present study,...
Cytokine-induced killer cells (CIK cells) are a heterogeneous subset of ex-vivo expanded T lymphocytes which characterized with MHC-unrestricted tumor-killing activity and mixed T-NK phenotype. Adoptive CIK transfer, one the adoptive immunotherapy represents promising nontoxic anticancer therapy. However, in clinical studies, therapeutic transfer is not as efficient anticipated. Possible explanations that abnormal tumor vasculature hypoxic microenvironment could impede infiltration efficacy...
Abstract Tumor hypoxia is one of the important features lung adenocarcinoma. Chemokines might mediate effects caused by tumor hypoxia. As confirmed in tissue and serum patients, CC chemokine 28 (CCL28) was only induced adenocarcinoma cells. CCL28 could promote tube formation, migration proliferation endothelial In addition, angiogenesis promoted chick chorioallantoic membrane matrigel implanted dorsal back athymic nude mice (CByJ.Cg- Foxn1 nu /J). Tumors formed cells with high expression...
Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide, which lacks effective biomarkers for prognosis. Therefore, it urgent to explore new potential molecular markers discriminate patients with poorer survival in ESCC. Bioinformatics analysis, qRT-PCR, and western blot were applied investigate S1PR1 expression. CCK-8 assay, colony formation flow cytometry dual staining immunofluorescence performed examine proliferation ability apoptosis rate. Mouse xenograft...
MicroRNA (miRNA) expression and functions have been reported to contribute phenotypic features of tumor cells. Although targets functional roles for many miRNAs described in lung adenocarcinoma (LAD), their pathophysiologic phenotypes chemoresistant LAD cells are still largely unclear. Previously, docetaxel (DTX)-resistant cell lines (SPC-A1/DTX H1299/DTX) were established by our laboratory displayed chemo- or radioresistance mesenchymal with enhanced invasiveness motility. Unbiased miRNA...
Radiotherapy failure is a significant clinical challenge due to the development of resistance in course treatment. Therefore, it necessary further study radiation mechanism HCC. In our early study, we have showed that expression Aurora-A mRNA was upregulated HCC tissue samples or cells, and promoted malignant phenotype cells. However, effect on radioresistance not well known.In this colony formation assay, MTT assays, flow cytometry RT-PCR Western blot, tumor xenografts experiments were used...
Although immunotherapy has changed the prognosis of many advanced malignancies including lung adenocarcinoma (LUAD), patients are insensitive to drugs, with mechanisms yet be elucidated. Herein, we identified PDE4D as an efficacy-related gene through bioinformatics screening. By using a co-culture system LUAD cells and tumor-cell-specific CD8+ T cells, functional PDE4D/cAMP/IL-23 axis was further revealed in cells. Fluorescent multiplex immunohistochemistry analysis patient-derived samples...
Accumulating evidence has indicated that preconditioning chemotherapy could eliminate the suppressive factors in antitumor immune response, thereby leading to full release of efficacy subsequent immunotherapy. In this study, a single subtoxic dose (5 mg/kg, intraperitoneally) cisplatin was chosen as combination with cytokine-induced killer (CIK) cells (4×10(6), intravenously) treat murine B16 melanoma xenografts. It found pretreatment enhance activity CIK cells. To explore potential...
Long-term uninterrupted therapy is essential for maximizing clinical benefits of antiangiogenic drugs (AADs) in cancer patients. Unfortunately, nearly all clinically available AADs are delivered to patients using disrupted regimens. We aim develop lifetime, nontoxic, effective, orally active, and low-cost antitumor treatment Here we report our findings long-term maintenance with low cost chemotherapeutics effective treatment. In a sequential regimen, robust effects tumors were achieved an...
High blood glucose has long been established as a risk factor for tumor metastasis, yet the molecular mechanisms underlying this association have not elucidated. Here we describe that hyperglycemia promotes metastasis via increased platelet activity. Administration of glucose, but fructose, reprogrammed metabolism megakaryocytes to indirectly prime platelets into prometastatic phenotype with adherence cells. In megakaryocytes, metabolism-related gene array identified mitochondrial chaperone...
Overexpression of both hypoxia-inducible factor 1α (HIF-1α) and Aurora A has been found in hepatocellular carcinoma (HCC). However, whether HIF-1α synergistically promote malignant phenotypes HCC cells is unknown. The purpose this study was to investigate the roles functional correlation progression. Immunohistochemistry performed detect protein expression 55 primary corresponding non-tumor tissues their clinical significance. Gene knockout technology using short hairpin RNA (shRNA) used...
Epithelial-mesenchymal transition (EMT) plays an important role in tumor metastasis of human nonsmall cell lung cancer (NSCLC). The Wnt pathway is identified as a key regulator normal tissue development, and its aberrant activation contributes to the process EMT. secreted frizzled-related protein 1 (sFRP1), Wnt-signaling antagonist, downregulated many tumors, including cancer. However, sFRP1 EMT remains unclear. In this study, we found that was dramatically transforming growth factor β1...
Significance Defining targets and functional impacts of systemic treatment with antiangiogenic drugs on tumors healthy tissues are crucial for understanding their therapeutic efficacy, drug resistance, adverse effects, timeline therapy. In the present study, we used both mouse human tumor models to recapitulate clinical situations in which were systemically delivered mice. Antiangiogenic at low dosages produced broad effects vessel regression several endocrine organs. Prolonged nonantitumor...