A5014654873- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- CAR-T cell therapy research
- Lung Cancer Research Studies
- Circular RNAs in diseases
- Immune cells in cancer
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Drug Transport and Resistance Mechanisms
- Chemokine receptors and signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
Yancheng First People's Hospital
2020-2024
Nantong University
2020-2024
Xuzhou Medical College
2023-2024
Nanjing University
2013-2024
Nanjing Medical University
2013-2024
Yancheng Third People's Hospital
2020-2024
Jiangsu Cancer Hospital
2024
Affiliated Hospital of Nantong University
2023
Nanjing General Hospital of Nanjing Military Command
2015-2018
Fuyang Maternity and Child Health Care Hospital
2015
Fibroblasts in the tumor stroma are well recognized as having an indispensable role carcinogenesis, including initiation of epithelial formation. The association between cancer cells and fibroblasts has been highlighted several previous studies. Regulation factors released from cancer‑associated (CAFs) into microenvironment have essential roles, support growth, angiogenesis, metastasis therapy resistance. A mutual interaction tumor‑induced fibroblast activation, fibroblast‑induced...
Abstract Cancer-associated fibroblasts (CAF) are recognized as one of the key determinants in malignant progression lung adenocarcinoma. And its contributions to chemoresistance acquisition cancer has raised more and attention. In our study, associated treated with cisplatin conferred cells. Meanwhile, Interleukin-11(IL-11) was significantly up-regulated CAF stimulated by cisplatin. As confirmed adenocarcinoma cells vivo vitro , IL-11 could protect from cisplatin-induced apoptosis thus...
Emerging evidence indicates that the dysregulation of long non-coding RNAs (lncRNAs) contributes to development and progression lung adenocarcinoma (LAD), however underlying mechanism action lncRNAs remains unclear. It is well known effective treatment cancers has been hindered by drug resistance in clinical setting. Epithelial-mesenchymal transition (EMT) recognized be involved acquiring resistance, cell migration invasion properties several types cancer. Docetaxel-resistant LAD cells...
Abstract Although many articles have uncovered that Wnt signaling is involved in radioresistance, the mechanism rarely reported. Here we generated two radioresistant cells rECA109 and rKyse150 from parental esophageal cancer ECA109 Kyse150. We then found activity was higher further activated upon ionizing radiation (IR) exposure. In addition, acquired epithelial-to-mesenchymal transition (EMT) properties stem quality. to be radioresistance by promoting DNA damage repair. our present study,...
Abstract Tumor hypoxia is one of the important features lung adenocarcinoma. Chemokines might mediate effects caused by tumor hypoxia. As confirmed in tissue and serum patients, CC chemokine 28 (CCL28) was only induced adenocarcinoma cells. CCL28 could promote tube formation, migration proliferation endothelial In addition, angiogenesis promoted chick chorioallantoic membrane matrigel implanted dorsal back athymic nude mice (CByJ.Cg- Foxn1 nu /J). Tumors formed cells with high expression...
AIM:To investigate the expression and prognostic value of CCL2 in gastric cancer, as well its relationship with tumor hypoxia. METHODS:Tumor tissues from 68 cancer patients (GC) were analyzed, hypoxia-inducible factor 1 alpha (HIF-1α) was detected by immunohistochemistry. Statistical evaluations that used included univariate logrank tests Kaplan-Meier curves multivariate Cox regression model analysis.RESULTS: highly expressed 66.2% (45/68) specimens.The distribution tissue consistent...
Accumulating evidence revealed that microRNAs (miRNAs) have been demonstrated as critical molecules in tumor development and progression. MiR-26a, located a fragile chromosomal region associated with various human cancer, has reported to be involved regulating cellular process, such proliferation, apoptosis invasion through targeting multiple oncogene. Docetaxel-mediated chemotherapy applied improving the survival prognosis of patients advanced lung adenocarcinoma (LAD). However,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in world. Recent researches have demonstrated that m6A methylation regulators play a key role various cancers, such as gastric cancer and colon adenocarcinoma. Several are reported to predict prognosis HCC. Therefore, there need further identify predictive value HCC.We utilized The Cancer Genome Atlas (TCGA) database obtain gene expression profile RNA clinical information for patients with Besides, we identified two...
Dickkopf-related protein 3 (DKK3) gene, as a tumor suppressor has been discovered in various cancers, but its relationship with chemoresistance is still unclear. In this study, laboratory detected that DNA methylation contributes to the downregulation of DKK3 docetaxel resistance human lung cancer cells and possible biochemical mechanism. proved be downregulated by hypermethylation docetaxel-resistant cells. Upregulation can reverse cell lines vitro growth inhibition enhancement apoptosis....
5-Fluorouracil is a commonly used chemotherapy drug for colorectal cancer. Resistance to remains challenge. This research aimed explore the mechanism of resistance in RT-qPCR and Western blot were determine RNA protein expression both cells exosome. Assays vitro vivo performed measure role miR-149-5p cancer cells. RIP, luciferase activity report, pulldown assay applied detect association PTOV1-AS1, SUV39H1, miR-149-5p, FOXM1. MiR-149-5p was down-expressed 5-Fluorouracil-resistant enhanced...
ObjectiveTo investigate the regulatory mechanism of EP300 in interaction between SLC16A1-AS1 and TCF3 to activate Wnt pathway, thereby promoting malignant progression lung cancer.MethodsIn cancer cell lines, was knocked down, impact this knockdown on cells assessed through clonogenic assays, Transwell apoptosis experiments. The relationship investigated bioinformatic analysis ChIP expression 56 paired tissues examined using RT-qPCR, their correlation analyzed. explored CoIP Activation...
Adoptive cell immunotherapy with cytokine-induced killer (CIK cell) represents a promising non-toxic anticancer therapy. However, the clinical efficacy of CIK cells is limited because abnormal tumor vasculature. Metronomic chemotherapy shows activity by its potential antiangiogenic effect and reduced toxicity. We hypothesized that metronomic paclitaxel could improve antitumor adoptive immunotherapy. Mice health status was analyzed measuring mice weight observing behavior....
Abstract Background Pulmonary high-grade neuroendocrine carcinoma (HGNEC) has a rising incidence of developing second primary malignancies (SPMs). This study is the first population-based analysis to quantify SPM risks among survivors lung HGNEC. Methods We used Surveillance, Epidemiology, and End Results (SEER) database calculate standardized ratio (SIR) absolute excess risk (AER) between 2000 2016 for patients with pulmonary The data 1161 SPMs were retrieved from SEER database....
Esophageal squamous cell cancer (ESCC) accounts for approximately 90% of esophageal cases in China. There are no standard regimens second or third-line chemotherapy metastatic cancer. The objective this study was to investigate the security and effectiveness irinotecan combined with raltitrexed monotherapy salvage ESCC.One hundred twenty-eight patients ESCC confirmed by histopathology were enrolled into study. These had failure first-line combination fluorouracil platinum paclitaxel not...
Objective To investigate the inhibitory effect and mechanism of Metformin (Met) combined with irradiation in CT26WT cell lines or mouse models transplanted tumors. Methods CT26WT line was treated 0.5μmol/L, 1.0μmol/L, 5.0μmol/L 10.0μmol/L Met, CellTiter Glo kit used to detect Met at different concentrations on viability cells. control, (10μmol/L), 15Gy irradiation+ (10μmol/L). Clone formation assay employed proliferation activity. Bablc tumors (tumor size>150 mm3) were established...
Abstract Background and Purpose :To immune checkpoint inhibitors (immune inhibitors, ICIs) as the representative of immunotherapy is more widely used in treatment lung cancer, this study was to evaluate recurrent metastatic non-small cell cancer (non – small cancer,NSCLC).Efficacy safety second-line chemotherapy combined with patients NSCLC. Methods :Twenty-three NSCLC who were admitted Yancheng First People's Hospital from June 2019 October 2021 progressed after first-line received...