A5027847977- Nutritional Studies and Diet
- Diet and metabolism studies
- Consumer Attitudes and Food Labeling
- Ferroptosis and cancer prognosis
- Nutrition, Genetics, and Disease
- Cancer Immunotherapy and Biomarkers
- Obesity, Physical Activity, Diet
- Lung Cancer Treatments and Mutations
- Diet, Metabolism, and Disease
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Alcohol Consumption and Health Effects
- Helicobacter pylori-related gastroenterology studies
- Additive Manufacturing and 3D Printing Technologies
- Colorectal Cancer Screening and Detection
- Liver Disease Diagnosis and Treatment
- Additive Manufacturing Materials and Processes
- Sodium Intake and Health
- Lung Cancer Research Studies
- Antioxidant Activity and Oxidative Stress
- interferon and immune responses
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Glioma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
Zhejiang Hospital
2015-2025
Zhejiang Ocean University
2023-2025
Xiangya Hospital Central South University
2023-2024
Central South University
2019-2024
Hunan Cancer Hospital
2022-2024
Second Xiangya Hospital of Central South University
2019-2023
Zhejiang University
2023
Anhui Medical University
2013-2014
Abstract Various forms of programmed cell death (PCD) exhibit distinct characteristics depending on their specific molecular mechanisms, and there are interactions among these different forms. Ferroptosis, which is related to autophagy apoptosis, has an unknown potential interaction with pyroptosis. This study revealed a mutually antagonistic relationship between ferroptosis pyroptosis, 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) playing key role in interaction. It found that...
No previous study has investigated dietary pattern in association with obesity risk a middle-aged Chinese population. The purpose of this was to evaluate the associations between patterns and city Hangzhou, capital Zhejiang Province, east China. In cross-sectional 2560 subjects aged 45–60 years, intakes were evaluated using semi-quantitative food frequency questionnaire (FFQ). All anthropometric measurements obtained standardized procedures. partial correlation analysis performed assess body...
In the treatment of most malignancies, radiotherapy plays a significant role. However, resistance cancer cells to ionizing radiation (IR) is main reason for failure radiotherapy, which causes tumor recurrence and metastasis. this study, we confirmed that GPR162, an orphan receptor in G-protein-coupled family, acted as novel sensitizer by interacting with stimulator interferon genes (STING), targeted DNA damage responses, activated IRF3, accelerated activation type I system, promoted...
Abstract Background Disulfidptosis is a type of programmed cell death caused by excessive cysteine-induced disulfide bond denaturation leading to actin collapse. Liver cancer has poor prognosis and requires more effective intervention strategies. Currently, the prognostic therapeutic value disulfidptosis in liver not clear. Methods We investigated features 16 disulfidptosis-related genes (DRGs) HCC patients TCGA classified into two pattern clusters consensus clustering analysis. Then, we...
Although previous studies reported the associations between intakes of individual foods or nutrients and risk non-alcoholic fatty liver disease (NAFLD), relationship dietary patterns NAFLD in Chinese population has been rarely studied to date. This study aimed investigate a middle-aged population. The Study subjects were 999 adults aged 45–60 years Anhui province who participated Hefei Nutrition Health Study. Dietary intake was collected by semi-quantitative food frequency questionnaire....
Although some studies have shown the associations between dietary patterns and risk T2DM in a general population, middle-aged Chinese been rarely studied to date. In this study, we aimed characterize adults aged 45-59y (n = 1918) evaluate relationship of T2DM.The study population was part population-based Nutrition Health Study conducted city Hangzhou, Zhejiang Province, China. Dietary intake assessed by using validated food frequency questionnaire (FFQ). Multivariate logistic regression...
Diagnosing and treating patients with multiple primary lung cancers (MPLCs) bring challenges to the clinic, preliminary evidence has revealed unsatisfying outcomes after targeted therapy immunotherapy. Therefore, we surveyed genomic profiles of MPLCs their possible associations tumor mutation burden (TMB), programmed death-ligand 1 (PD-L1), immune cell infiltration landscape.A total 112 surgically resected 294 tumors were eligible, 255 sequenced using a 1021-gene panel. Immunohistochemistry...
Ulcerative colitis (UC) is a recurring inflammatory bowel disease, in which oxidative stress plays role its progression, and regulation of the oxidative/antioxidative balance has been suggested as potential target for treatment UC. The aim this study was to evaluate protective effect andrographolide against UC antioxidant properties by modulating nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. Dextran sulfate sodium (DSS) -induced mice LPS-induced HT29 cell model...
Epidemiological studies of different dietary patterns and the risk hypertension among a middle-aged Chinese population remain extremely scare. Thus, aim this study was to identify investigate relationship between adults aged 45–60 years. The present cross-sectional includes 2560 participants who reported their intake using validated food frequency questionnaire (FFQ). Dietary were identified factor analysis. Anthropometric measurements obtained standardized procedures. We used log-binomial...
Alcohol-related liver disease (ALD) is one of the most prevalent forms in world. Acetaldehyde, an intermediate product alcohol catabolism, a cause injury caused by alcohol. This study was designed to evaluate protective role and mechanism(s) genistein against acetaldehyde-induced pathological process ALD. We found that administration significantly ameliorated alcohol-induced hepatic steatosis, injury, inflammation mice. Genistein supplementation markedly reversed oxidative stress,...
Epigenetic regulators and posttranslational modifications of proteins play important roles in various kinds cancer cell death, including ferroptosis, a non-apoptotic form death. However, the interplay chromatin modifiers deubiquitinase (DUB) ferroptosis remains unclear. Here, we found that ubiquitin-specific protease 5 (USP5) is regarded as bona fide DUB lymphoid-specific helicase (LSH), DNA methylation repressor, hepatocellular carcinoma (HCC). Functional studies reveal USP5 interacts with...
Wire arc additive manufacturing (WAAM) is a promising technology in aerospace, automotive, and marine industries due to its high efficiency cost-effectiveness. However, the dynamic behavior of melt pool significantly affects forming quality requires real-time accurate monitoring. In this paper, novel multi-branch residual network for monitoring proposed, which addresses limitations traditional methods single-branch networks. The structure effectively extracts multi-scale features, while...