A5100686891- Diabetes and associated disorders
- Diabetes Management and Research
- Lung Cancer Treatments and Mutations
- Pancreatic function and diabetes
- Diabetes Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Advanced Breast Cancer Therapies
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Gene expression and cancer classification
- Genomics and Phylogenetic Studies
- Ferroptosis and cancer prognosis
- T-cell and B-cell Immunology
- Advanced Biosensing Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Circular RNAs in diseases
- Inflammatory Biomarkers in Disease Prognosis
- Fractal and DNA sequence analysis
- Metabolism, Diabetes, and Cancer
- Machine Learning in Bioinformatics
- Single-cell and spatial transcriptomics
- Pharmacology and Obesity Treatment
Chongqing Three Gorges University
2025
Chongqing University
2025
Chengdu Medical College
2024
Central South University
2013-2024
Second Xiangya Hospital of Central South University
2013-2024
Creative Commons
2024
Fudan University Shanghai Cancer Center
2023
First People’s Hospital of Jingmen
2023
Union Hospital
2023
Huazhong University of Science and Technology
2023
Background The recent development of metagenomic sequencing makes it possible to massively sequence microbial genomes including viral without the need for laboratory culture. Existing reference‐based and gene homology‐based methods are not efficient in identifying unknown viruses or short sequences from data. Methods Here we developed a reference‐free alignment‐free machine learning method, DeepVirFinder, data using deep learning. Results Trained based on RefSeq discovered before May 2015,...
OBJECTIVE B lymphocytes play an important role in the immunopathogenesis of autoimmune diabetes. We hypothesized that altered B-cell subset phenotype is associated with RESEARCH DESIGN AND METHODS Patients type 1 diabetes (T1D) (n = 81), latent adults (LADA) 82), or 2 (T2D) 95) and healthy control subjects 218) normal glucose tolerance (NGT) were recruited. determined percentage circulating B-lymphocyte subsets, including CD19+CD23−CD21+ (marginal zone [MZB]), CD19+CD23+CD21− (follicular...
Notoginsenoside R1 (R1) is the main bioactive component in <i>Panax notoginseng</i>, an old herb medicine widely used Asian countries treatment of microcirculatory diseases. However, little known about effect on inflammatory bowel disease (IBD). The present study demonstrated that alleviated severity dextran sulfate sodium–induced colitis mice by decreasing activity myeloperoxidase, production cytokines, expression proinflammatory genes, and phosphorylation I<i>κ</i>B kinase,...
Diagnosing and treating patients with multiple primary lung cancers (MPLCs) bring challenges to the clinic, preliminary evidence has revealed unsatisfying outcomes after targeted therapy immunotherapy. Therefore, we surveyed genomic profiles of MPLCs their possible associations tumor mutation burden (TMB), programmed death-ligand 1 (PD-L1), immune cell infiltration landscape.A total 112 surgically resected 294 tumors were eligible, 255 sequenced using a 1021-gene panel. Immunohistochemistry...
Patients with HER2-positive (HER2+) metastatic breast cancer (MBC) have poor prognoses. Pyrotinib has shown promising antitumor activity in MBC to improve progression-free survival (PFS). However, findings based on real-world data analyze whether pyrotinib affects overall (OS) remain scarce.This study is an exploratory analysis of brain metastasis (BM) and the final update our preceding 168 patients HER2+ MBC. PFS, OS, tumor mutation burden (TMB), clinical benefit rate (CBR), response (ORR)...
The species accumulation curve, or collector's of a population gives the expected number observed distinct classes as function sampling effort. Species curves allow researchers to assess and compare diversity across populations evaluate benefits additional sampling. Traditional applications have focused on ecological but emerging large-scale applications, for example in DNA sequencing, are orders magnitude larger present new challenges. We developed method estimate predicting complexity...
Background: Pyrotinib, an irreversible pan-ERBB inhibitor, has shown promising antitumour activity, and acceptable tolerability. This research was conducted to evaluate the actual use effectiveness of pyrotinib in China, therefore, contributed solve problem real-world data scarcity. Methods: In this retrospective study, 168 patients who received treatment for HER2-positive metastatic breast cancer (MBC) Hunan Province from June 2018 August 2019 were included. Progression-free survival (PFS),...
Objective: To examine the effect of cumulative hemoglobin A1c (HbA1c) levels and insulin dosage on resistance (IR)-related metabolic disturbances in newly diagnosed patients with type 1 diabetes (T1D). Methods: This retrospective cohort study included T1D admitted to Second Xiangya Hospital Central South University from November 2015 March 2023. Clinical data collected comprised age, sex, disease duration, dosage, body mass index, waist circumference, blood pressure, HbA1c levels, islet...
Abstract EGFR-TKIs have been widely used in the first-line treatment of NSCLC patients harboring EGFR mutations. However, prognosis indicators are limited. In present study, prognostic value systemic immune-inflammation index (SII), neutrophil to lymphocyte ratio (NLR), and platelet (PLR) were assessed EGFR-Mutant lung adenocarcinoma treated with first-generation EGFR-TKIs. Two hundred three included this retrospective analysis. SII was calculated as counts × / counts. Receiver operating...
The emergence of immune checkpoint inhibitors (ICIs) has significantly prolonged the survival time cancer patients. However, it may also lead to various immune-related adverse events (irAEs), including Guillain–Barré syndrome (GBS), a rare type irAE. Most GBS patients can recover spontaneously due self-limited nature disease, but severe cases result in respiratory failure or even death. Here we report case occurring 58-year-old male patient with non-small cell lung (NSCLC) who developed...
The aim of this work was to investigate whether tetraspanin 7 autoantibodies (TSPAN7A) are valuable in predicting poor beta cell function individuals with latent autoimmune diabetes adults (LADA). cross-sectional study involved participants LADA (n = 173), type 1 158), 2 204) and healthy control 170). longitudinal 53 LADA, a 3-year follow-up. In both cohorts, TSPAN7A the sera were measured by luciferase immunoprecipitation system assay, physical clinical characteristics recorded. prevalence...
T lymphocytes are key players in the pathogenesis of autoimmune diabetes. We recruited subjects with T1D (n=81), LADA (n=82), T2D (n=95) and NGT (n=218) analyzed percentages T-lymphocyte subsets, including helper 1 (Th1), 2 (Th2), 17 (Th17), cytotoxic (Tc1), regulatory cells (Tregs), effector (Teff), naïve T, central memory (Tcm), (Tem) by flow cytometry. patients possessed similar frequencies IFN-γ+CD4+ IFN-γ+CD8+ CD4+ Teff compared patients, but much lower than those subjects. Like had...
Introduction The combination of a PD-L1 inhibitor plus carboplatin/cisplatin and etoposide (EC/EP) has become new standard first-line treatment for extensive-stage small-cell lung cancer (ES-SCLC). Combining concurrent palliative hypofractionated radiotherapy the thorax (HFRT) immunochemotherapy may have synergistic effect. In this study, we explored an optimal model with as ES-SCLC. Patients methods multicenter single-arm phase 2 trial, patients ES-SCLC received atezolizumab EC/EP two...
Abstract Latent autoimmune diabetes in adults ( LADA ) is a form of with features both type 1 and 2 the middle spectrum. Scientists clash on question whether this unique subtype. Multicenter studies have been performed different countries, including K orea N ational D iabetes P rogram KNDP collaboratory group, E hime study J apan, ot I nsulin‐ R equiring A utoimmune NIRAD taly, ord‐ T røndelag H ealth HUNT orway, UK rospective S tudy UKPDS , ction urope C hina hina. These found universal...
The recent development of metagenomic sequencing makes it possible to sequence microbial genomes including viruses in an environmental sample. Identifying viral sequences from data is critical for downstream virus analyses. existing reference-based and gene homology-based methods are not efficient identifying unknown or short sequences. Here we have developed a reference-free alignment-free machine learning method, DeepVirFinder, predicting using deep techniques. DeepVirFinder was trained...