A5052434131- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- HER2/EGFR in Cancer Research
- Cancer and Skin Lesions
- Chemokine receptors and signaling
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Cancer Treatment and Pharmacology
- Cancer Diagnosis and Treatment
- interferon and immune responses
- Cancer, Stress, Anesthesia, and Immune Response
- Immunotherapy and Immune Responses
- Lymphatic System and Diseases
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Breast Implant and Reconstruction
- Diagnosis and Treatment of Venous Diseases
- Genital Health and Disease
- Histiocytic Disorders and Treatments
- Inflammatory mediators and NSAID effects
- Parvovirus B19 Infection Studies
- Trace Elements in Health
- RNA modifications and cancer
- Graphene and Nanomaterials Applications
- Appendicitis Diagnosis and Management
Guangzhou Medical University Cancer Hospital
2025
Guangzhou Medical University
2025
Third Xiangya Hospital
2013-2025
Central South University
2013-2025
Yahoo (United Kingdom)
2005
Breast cancer is one of the most common malignancies threatening women's health. Triple-negative breast (TNBC) a special type with high invasion and metastasis. CXCL12 its receptors CXCR4 CXCR7 play crucial role in progress cancer. The aim this study was to investigate effect on function TNBC.We used CRISPR/Cas9 technique carry out single knockout or gene co-knockout genes TNBC cell line (MDA-MB-231). cells were screened verified by PCR sequencing Western blot assay, proliferation examined...
Background: Pyrotinib, an irreversible pan-ERBB inhibitor, has shown promising antitumour activity, and acceptable tolerability. This research was conducted to evaluate the actual use effectiveness of pyrotinib in China, therefore, contributed solve problem real-world data scarcity. Methods: In this retrospective study, 168 patients who received treatment for HER2-positive metastatic breast cancer (MBC) Hunan Province from June 2018 August 2019 were included. Progression-free survival (PFS),...
Purpose: To determine the role of UCH-L1 in regulating ERα expression, and to evaluate whether therapeutic targeting can enhance efficacy anti-estrogen therapy against breast cancer with loss or reduction ERα. Methods: Expressions were examined cells patient specimens. The associations between ERα, response prognosis patients analyzed using multiple databases. molecular pathways by which regulates immunoblotting, qRT-PCR, immunoprecipitation, ubiquitination, luciferase ChIP assays. effects...
Abstract Introduction The survival benefit of hyperthermic intraperitoneal chemotherapy (HIPEC) has been well defined at the time interval cytoreductive surgery, but role HIPEC remains uncertain for patients with newly diagnosed advanced ovarian cancer in upfront setting. present study aimed to report updated long‐term outcomes after 5 years follow‐up from our previous multicenter retrospective cohort compare primary surgery (PCS) plus PCS alone among women stage III epithelial cancer....
To compare the efficacy and safety between Mammotome vacuum-assisted breast biopsy (Mammotome VABB) conventional open excision for benign tumor.A computer-based online search of Medline, PubMed, Embase, Ovid, Cochrane Library, VIP, Wanfang, CNKI Chinese Biological Medicine Database was performed, conference references were manually searched. With Collaboration Guidelines, all randomized controlled trials comparing mammotome minimally invasive operation systematically reviewed. The...
Background: Docetaxel is an important chemotherapy-agent for breast cancer treatment. One of its side-effects weight gain, which increases the all-cause mortality rate. Considering gut microbiota one factor regulation, we hypothesized that probiotics could be potentially used to reduce docetaxel-related gain in patients. Methods: From 10/8/2018 10/17/2019, 100 (Stage I-III) patients underwent four cycles docetaxel-based chemotherapy were enrolled and randomly assigned receive...
To study the expressions and clinical significance of chemokine CXCL12 its receptor CXCR4, CXCR7 in human breast carcinoma (BC) with different molecular subtypes. Methods: The mRNA CXCL12, CXCR4 tissues from 80 patients subtype BC were measured by qRT-PCR. protein paraffin-embedded samples 160 subtypes detected immunohistochemical staining. Results: expression levels HER-2 positive TNBC significantly higher than those luminal A B (all P<0.05), but their not between or tissues. rates while...
Background: Pyrotinib is a novel irreversible pan-ErbB receptor tyrosine kinase inhibitor. Evidence of the efficacy pyrotinib-based treatments for HER2-positive metastatic breast cancer (MBC) in patients exposed to lapatinib limited. Methods: Ninety-four who received pyrotinib as third- or higher-line treatment MBC were included this retrospective study. The primary and secondary endpoints overall survival (OS) progression‐free (PFS). Propensity score matching (PSM) inverse probability...
We aimed to identify a signature comprising N6-methyladenosine (m6A)-related long non-coding RNAs (lncRNAs) and molecular subtypes associated with breast cancer (BRCA). obtained data of BRCA samples from The Cancer Genome Atlas database. m6A-related lncRNA prognostic (m6A-LPS) included 10 lncRNAs previously identified as was constructed using integrated bioinformatics analysis validated. Accordingly, risk score based on the m6A-LPS established shown confirm differences in survival between...
The regulatory roles of human epidermal growth factor receptor [erb-b2 tyrosine kinase 4 (ERBB)] family in tumors was received widespread attention. Although ERBB4 crucial regulator metastasis malignant tumors, the exact mechanism inflammatory breast cancer (IBC) remains unclarified.In this study, we collected IBC tissues and cell lines, explored expression levels platelet-derived alpha (PDGFRA) using real-time quantitative polymerase chain reaction (RT-PCR), immunohistochemistry (IHC)...
Previous studies have demonstrated that mastoscopic sentinel lymph node biopsy (MSLNB) has good identification rate (IR) and low false negative (FNR). However, few directly compared the surgical performance peri- post-operative factors of MSLNB with conventional (SLNB).Sixty patients diagnosed breast cancer were recruited randomly assigned to one three groups: MSLNB, SLNB lipolysis injection. Peri- parameters using general linear models. To examine effect age on these parameters, we...
Background: This study was performed to explore the safety of breast cancer (BC) mastoscopic surgery from perspective immunity and adipokines. Method: A single-center, prospective, randomized controlled trial carried out among 42 patients who had undergone December 2018 July 2019. All were randomly divided into an open group (n = 21) a 21). Flow cytometry used detect natural killer (NK), CD4+ T cells, CD8+ regulatory (Treg) cells in each 1 d before surgery, h after operation, 1, 5, 7...
Understanding the factors that contribute to variability in breast cancer-related lymphedema (BCRL) is an important first step developing targeted interventions improve quality of life cancer patients. Although previous research studies have has identified many risk for BCRL, dietary habits and catheterization type rarely been studied until present. This study aims explore effects nursing such as on (BCRL). retrospective cohort included 1,476 patients who underwent surgery between January 1,...
Background: Hand-foot syndrome (HFS) and oral mucositis (OM) are common adverse events during cancer chemotherapy can significantly decrease patients’ quality of life adaptation, however, prevention strategies these complications yet to be established. Methods: Patients with stage I-III breast cancer, who had surgery needed pegylated liposomal doxorubicin (PLD)-based adjuvant were screened, recruited randomly assigned receive either probiotics or placebo (three capsules, twice/day) treatment...
To observe the effect of parecoxib on neutrophil-to-lymphocyte ratio (NLR)after modified radical mastectomy, and to explore its potential mechanisms for inhibition perioperative inflammation. Methods: A total 40 breast cancer patients undergone mastectomy were randomly divided into a group (n=20) control (n=20). The received intravenous (40 mg, 5 mL) during general anesthesia induction, post-operative day 1 2; normal saline (5 at corresponding time points. Their peripheral bloods collected...