A5100424602- Autophagy in Disease and Therapy
- Chronic Disease Management Strategies
- Inflammatory Myopathies and Dermatomyositis
- Mosquito-borne diseases and control
- MicroRNA in disease regulation
- Pain Mechanisms and Treatments
- Immunodeficiency and Autoimmune Disorders
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Immune responses and vaccinations
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Influenza Virus Research Studies
- Respiratory viral infections research
- Hydrogen's biological and therapeutic effects
- SARS-CoV-2 and COVID-19 Research
- Eosinophilic Disorders and Syndromes
- Neurological Disorders and Treatments
- Biochemical effects in animals
- Optical Imaging and Spectroscopy Techniques
- Vitamin D Research Studies
- Adipokines, Inflammation, and Metabolic Diseases
Hunan Normal University
2025
Institute of Hydrobiology
2022-2025
Chinese Academy of Sciences
2022-2025
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2025
University of Chinese Academy of Sciences
2022-2025
Xuzhou Medical College
2023-2025
First People's Hospital of Jingzhou
2021-2025
Xian Yang Central Hospital
2021-2025
Zhejiang University
2021-2025
Nanjing Medical University
2025
The accumulation of ubiquitin-positive protein aggregates has been implicated in the pathogenesis neurodegenerative diseases, heart disease and diabetes. Emerging evidence indicates that autophagy lysosomal pathway plays a critical role clearance ubiquitin aggregates, process is mediated by binding p62. In addition to ubiquitin, p62 also interacts with LC3 transports conjugates autophagosomes for degradation. exact regulatory mechanism this still largely unknown. Here we report...
Abstract The research employed network toxicology and molecular docking techniques to systematically examine the potential carcinogenic effects mechanisms of aspartame ( l -α-aspartyl- -phenylalanine methyl ester). Aspartame, a commonly used synthetic sweetener, is widely applied in foods beverages globally. In recent years, its safety issues, particularly risk, have garnered widespread attention. study first constructed an interaction map with gastric cancer targets using methods identified...
The adipokines chemerin and adiponectin are reciprocally related in the pathogenesis of insulin resistance inflammation obesity. Weight loss increases reduces chemerin, resistance, inflammation, but effects caloric restriction physical activity difficult to separate combined lifestyle modification. We compared diet- or exercise-induced weight on adiponectin, obese men. Eighty abdominally Asian men (body mass index [BMI] ≥ 30 kg/m(2), waist circumference [WC] 90 cm, mean age 42.6 years) were...
This study includes a retrospective analysis of the diagnosis and treatment case severe pneumonia from fulminant psittacosis with multiple organ failure. Next-generation sequencing (NGS) pathogen was conducted. The purpose this to summarize clinical, laboratory, imaging characteristics improve understanding value NGS in community-acquired (CAP). Fulminant can be manifested as rapid progression, acute respiratory distress syndrome, sepsis, Imaging shows unilateral lung consolidation, which is...
Our recent study demonstrated the critical role of mesolimbic dopamine (DA) circuit and its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The present aims to investigate functional GABAergic inputs from lateral hypothalamus (LH) ventral tegmental area (VTA; LHGABA→VTA) regulating DA BDNF underlying physiological pathologic We that optogenetic manipulation LHGABA→VTA projection bidirectionally regulated pain sensation naive male mice. Optogenetic inhibition...
The abnormal proliferation and inflammatory response of the mesangial cells play a crucial role in progression membranous nephropathy (MN). Herein, this study aimed to investigate therapeutic effect Salvianolic acid B (SalB) on MN-induced abnormalities its underlying mechanisms. MN models were established cationic bovine serum albumin-induced Sprague-Dawley rats lipopolysaccharide-induced human (HMCs). Following SalB microRNA-145-5p antagomir treatment, kidney function was investigated by...
Fish possess a powerful IFN system to defend against aquatic virus infections. Nevertheless, spring viremia of carp (SVCV) causes large-scale mortality in common and significant economic losses aquaculture. Therefore, it is necessary investigate the strategies used by SVCV escape response. In this study, we show that nucleoprotein (N protein) negatively regulates cellular production degrading stimulator genes (STING) via autophagy-lysosome-dependent pathway. First, overexpression N protein...
Despite women representing most of those affected by major depression, preclinical studies have focused almost exclusively on male subjects, partially due to a lack ideal animal paradigms. As the persistent need regarding sex balance neuroscience research and female-specific pathology mental disorders surges, establishment natural etiology-based systematically validated paradigms for depression with female subjects becomes an urgent scientific problem. This study aims establish,...
ABSTRACT Aims To classify the unmet integrated care needs of older adults with multimorbidity and to explore factors associated different categories among target population. Design A cross‐sectional survey using statistical method latent profile analysis. Methods From July 2022 March 2023, 397 multimorbidity, aged 60 years or older, were recruited from one primary healthcare setting four secondary tertiary hospitals participate in face‐to‐face questionnaire surveys. The used this study...
Although fish possess an effective interferon (IFN) system to defend against viral infection, grass carp reovirus (GCRV) still causes epidemic hemorrhagic disease and tremendous economic loss in carp. Therefore, it is necessary investigate the immune escape strategies employed by GCRV. In this study, we show that structural protein VP4 of GCRV (encoded S6 segment) significantly restricts IFN expression degrading stimulator genes (STING) through autophagy-lysosome-dependent pathway. First,...
Although the classical biological protein cell cycle kinase CDK2 has been extensively studied in higher vertebrates, its function lower vertebrates beyond regulation of mitosis remains unknown. In this study, we report a distinct mechanism whereby IFN expression is negatively regulated fish by CDK2. After infection with spring viremia carp virus (SVCV), significantly increased tissues and cells. Moreover, antiviral resistance was improved cdk2 −/− homozygotes, cytokine interferon (IFN)...
Sphingosine-1-phosphate receptor-1 (S1PR1), a G protein-coupled receptor, has been reported to be involved in lymphangiogenesis. Degradations of extracellular matrix (ECM) are recognized as dynamic modulators regulating the formation new lymphatic vessels. However, little research studied ECM on S1PR1 regulation endothelial cells (LECs) tumor Here we attempt investigate hyaluronan fragments abundant microenvironment (TME) vessel formation. First, verified that low molecular weight (LMW-HA)...
Chronic hepatitis B (CHB) patients receiving entecavir (ETV) treatment might develop low-level viremia (LLV), which is proven to be associated with worse clinical outcomes, such as risk of drug-related mutations, progression cirrhosis, and even hepatocellular carcinoma. This real-world prospective study evaluated the efficacy safety switching from ETV tenofovir alafenamide fumarate (TAF) in CHB LLV. From August 2020 2023, 351 ETV-experienced LLV were enrolled eight hospitals. Patients either...