A5030033164- Pain Mechanisms and Treatments
- Stress Responses and Cortisol
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- RNA Research and Splicing
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Sarcoma Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- High voltage insulation and dielectric phenomena
- Neuropeptides and Animal Physiology
- Neurotransmitter Receptor Influence on Behavior
- Nerve injury and regeneration
- Sleep and Wakefulness Research
- Pediatric Pain Management Techniques
- Molecular spectroscopy and chirality
- Cardiac tumors and thrombi
- Aerosol Filtration and Electrostatic Precipitation
- Bone Tumor Diagnosis and Treatments
- Sex and Gender in Healthcare
- Pain Management and Placebo Effect
- Cancer, Stress, Anesthesia, and Immune Response
- Musculoskeletal pain and rehabilitation
- Ion channel regulation and function
Xuzhou Medical College
2019-2025
National Medical Products Administration
2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Zhongshan Hospital
2022
Fudan University
2022
Sun Yat-sen University
2022
Wuhan University
2020-2022
University of Pittsburgh
2021-2022
Dysfunctions of gene transcription and translation in the nociceptive pathways play critical role development maintenance chronic pain. Circular RNAs (circRNAs) are emerging as new players regulation expression, but whether how circRNAs involved pain remain elusive. We showed here that complete Freund's adjuvant-induced inflammation significantly increased circRNA-Filip1l (filamin A interacting protein 1-like) expression spinal neurons mice. Blockage this increase attenuated behaviors,...
Women suffer from depression at twice the rate of men, but underlying molecular mechanisms are poorly understood. Here, we identify marked baseline sex differences in expression long noncoding RNAs (lncRNAs), a class regulatory transcripts, human postmortem brain tissue that profoundly lost depression. One such lncRNA, RP11-298D21.1 (which termed FEDORA), is enriched oligodendrocytes and neurons up-regulated prefrontal cortex (PFC) depressed females only. We found virally expressing FEDORA...
Our recent study demonstrated the critical role of mesolimbic dopamine (DA) circuit and its brain-derived neurotropic factor (BDNF) signaling in mediating neuropathic pain. The present aims to investigate functional GABAergic inputs from lateral hypothalamus (LH) ventral tegmental area (VTA; LHGABA→VTA) regulating DA BDNF underlying physiological pathologic We that optogenetic manipulation LHGABA→VTA projection bidirectionally regulated pain sensation naive male mice. Optogenetic inhibition...
Abstract Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, underlying circuit mechanisms remain underexplored. Here, we focus on pain-induced remodeling projection from mediodorsal thalamus (MD) to anterior cingulate cortex (ACC), a that relays spinal input for processing. Using optogenetics combined with slice electrophysiology, detected male mice 7 days chronic constriction injury (CCI; achieved by loose...
Robust sex difference among humans regarding psychiatry- and pain-related behaviors is being researched; however, the use of female mice in preclinical research relatively rare due to an unchecked potential behavioral variation over estrous cycle. In present study, a battery are examined under physiological condition C57BL/6J different cycle phases: proestrus, estrous, metestrous, diestrous. Our results reveal that there no significant phases social interaction test, sucrose preference tail...
The nucleus accumbens shell (NAcSh) regulates emotional and motivational responses, a function mediated, in part, by integrating prioritizing extensive glutamatergic projections from limbic paralimbic brain regions. Each of these inputs is thought to encode unique aspects arousal. do not operate alone, but rather are often activated simultaneously during motivated behaviors, which they can interact coordinate shaping behavioral output. To understand the anatomic physiological bases...
Long-term limb nerve injury often leads to mirror-image pain (MIP), an abnormal sensation in the contralateral injury. Although it is clear that MIP mediated part by central nociception processing, underlying mechanisms remain poorly understood. The anterior cingulate cortex (ACC) a key brain region receives relayed peripheral nociceptive information from limb. In this study, we induced male mice, which unilateral chronic constrictive of sciatic (CCI) decreased threshold both hind limbs and...
<title>Abstract</title> Both peripheral and central CRF systems have been implicated in regulating pain sensation. However, compared with the peripheral, mechanisms underlying system modulation not yet elucidated, especially at neural circuit level. The corticoaccumbal circuit, a structure rich receptors CRF-positive neurons, plays an important role behavioral responses to stressors including nociceptive stimuli. present study was designed investigate whether how signaling this regulated...
Abstract Women suffer from depression at twice the rate of men, but underlying molecular mechanisms are poorly understood. Here, we identify dramatic baseline sex differences in expression long noncoding RNAs (lncRNAs) human postmortem brain tissue that profoundly lost depression. One such lncRNA, RP11-298D21.1 (which termed FEDORA), is enriched oligodendrocytes and neurons upregulated several cortical regions depressed females not males. We found virally-expressing FEDORA selectively either...
The existence of free metallic particle poses a serious threat to the oil insulation in power transformer. And ungrounded conductors transformer is generally covered by solid dielectrics, e.g. paper. introduction paper will change charged performance particle, so its motion behaviours and partial discharge (PD) characteristics be different from case with bare electrodes. In order clarify these, circulation flow device was built. movement particles diameter 150μm recorded high-speed camera....