A5101408591- Emotion and Mood Recognition
- Color perception and design
- Healthcare and Venom Research
- HIV-related health complications and treatments
- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Bee Products Chemical Analysis
- Cholesterol and Lipid Metabolism
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Nutritional Studies and Diet
- HIV/AIDS drug development and treatment
- Drug Transport and Resistance Mechanisms
- Consumer Attitudes and Food Labeling
- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Analytical Chemistry and Chromatography
- Lipoproteins and Cardiovascular Health
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Asymmetric Hydrogenation and Catalysis
Zhejiang Hospital
2015-2024
University of Electronic Science and Technology of China
2024
Chengdu Medical College
2024
South China University of Technology
2017-2023
Dongguan People’s Hospital
2021
Guangdong Medical College
2014-2021
Southern Medical University
2021
St. John's University
2018-2020
Guangxi University
2014-2019
Affiliated Hospital of North Sichuan Medical College
2016-2019
Abstract Background PI3K/AKT is a vital signaling pathway in humans. Recently, several inhibitors were reported to have the ability reverse cancer multidrug resistance (MDR); however, specific targets pathways and mechanisms associated with MDR not been found because many of multiple within large candidate protein pool. AKT activation one presumed mechanism by which develops during treatment. Methods The effects inhibiting PI3K 110α 110β BAY-1082439 treatment CRISPR/Cas9 knockout examined...
No previous study has investigated dietary pattern in association with obesity risk a middle-aged Chinese population. The purpose of this was to evaluate the associations between patterns and city Hangzhou, capital Zhejiang Province, east China. In cross-sectional 2560 subjects aged 45–60 years, intakes were evaluated using semi-quantitative food frequency questionnaire (FFQ). All anthropometric measurements obtained standardized procedures. partial correlation analysis performed assess body...
The overexpression of ABC transporters induced by anticancer drugs has been found to be the main cause multidrug resistance. It is actually also a strategy which cancer cells escape being killed. Tetrandrine natural product extracted from stem Tinospora crispa. In this study, tetrandrine showed synergistic cytotoxic activity in combinational use with chemotherapeutic drugs, such as Doxorubicin, Vincristine, and Paclitaxel, both drug-induced MDR1 gene-transfected that over-expressed...
The objective of this study was to determine the effects and potential mechanisms C-reactive protein (CRP) on cholesterol efflux from human macrophage foam cells, which may play a critical role in atherogenesis.Human THP-1 monocytes peripheral blood mononuclear cells (PBMCs) were preincubated with acetylated LDL [3H]-cholesterol form then treated apolipoprotein A-I (apoA-I) or HDL for assay. Clinically relevant concentrations CRP significantly reduced PBMCs apoA-I HDL. decreased expression...
Affective materials have always been an important factor in improving the efficiency of affect related research for their ecological validity. In order to achieve high validity emotion elicitation, this paper proposed a novel Virtual Reality System (AVRS) by utilizing immersion, privacy and design flexibility virtual reality. Design elements including subject features, sound motion features color were extracted referring referenced materials, art works existing VR scenes. scenes then...
The present affective stimulation systems have shortages in terms of inefficient emotion evocation and poor immersion. This paper presents the design, instructions ratings a novel Affective Virtual Reality System (AVRS), which includes large set emotionally-evocative VR scenes their ratings. It can provide more objective direct stimuli basic emotions (happiness, sadness, fear, relaxation, disgust, rage) by shielding environmental interferences. In this study, been designed using various...
Abstract Establishing thrombosis‐resistant surface is crucial to develop tissue‐engineered small diameter vascular grafts for arterial reconstructive procedures. The objective of this study was evaluate the stability and anti‐coagulation properties heparin covalently linked decellularized porcine carotid arteries. Cellular components arteries were completely removed with chemical physical means. Heparin vessels by a reaction carboxyl end amino acids hydroxylamine sulphate salt heparin‐EDC....
Mitogen- and Stress-Activated Kinase 1 (MSK1) is a nuclear kinase that serves as active link between extracellular signals the primary response of gene expression. However, involvement MSK1 in malignant transformation cancer development not well understood. In this study, we aimed to explore role Epstein-Barr virus (EBV) latent membrane protein (LMP1)-promoted carcinogenesis nasopharyngeal carcinoma (NPC).The level phosphorylation at Thr581 was detected by immunohistochemical analysis NPC...
Various of methods have been proposed for emotional induction including affective pictures, audios, and video clips. However, significant limitations exhibited such as low emotion elicitation efficiency high susceptibility to ambient interferences. Considering virtual reality (VR) provides a more immersive authentic audio-visual sense, this paper puts forward an system using VR named Affective Virtual Reality System (AVRS). Firstly, the multi-features were extracted classified from existing...
Cancer pathogenesis is influenced by epigenetic alterations mediated circular RNAs (circRNAs). In this study, we aimed to investigate the regulatory mechanisms and cytological function of hsa_circ_0006470/miR-27b-3p in gastric cancer (GC). circRNA microRNA expressions cells were measured qRT-PCR method. A dual-luciferase reporter assay was performed validate binding hsa_circ_0006470 with miR-27b-3p. silenced AGS cells, proliferation, migration, invasion tested via CCK-8 Transwell system,...
Abstract This study aimed to investigate the role of genetic variants including single nucleotide polymorphisms (SNPs) and copy number (CNVs) TBX21 , GATA3 Rorc Foxp3 genes in Behcet's disease (BD) Vogt-Koyanagi-Harada (VKH) syndrome a Chinese Han population. Genotyping 25 SNPs was performed by iPLEX system (Sequenom) or polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). TaqMan real time PCR used assess CNVs. The expression were examined real-time cytokine...
Refractive error (RE) is a complex multifactorial disease. Genome-wide association studies (GWAS) have provided significant insight into the genetic architecture and identified plenty of robust variations or single nucleotide polymorphisms (SNPs) associated with A major current challenge to convert those resources causal variants target genes. We used RegulomeDB HaploReg annotate regulatory information onto SNPs derived from two largest RE GWAS, additional in linkage disequilibrium (LD) GWAS...
Acute anterior uveitis (AAU) is the most common form of and a frequent ocular manifestation ankylosing spondylitis (AS). Thymocyte CD4+ cells have been reported to play an important role in pathogenesis both AAU AS. To test whether copy number variations (CNVs) T cell transcription factor genes including T-bet, GATA binding protein 3 (GATA)-3, related orphan receptor C (RORC) forkhead box (FOXP3) are associated with acute either presence or absence (AAU+AS+; AAU+AS-).The study included 676...