A5101415281- Gut microbiota and health
- PARP inhibition in cancer therapy
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Clostridium difficile and Clostridium perfringens research
- Circular RNAs in diseases
- Plant tissue culture and regeneration
- Cancer Cells and Metastasis
- Anesthesia and Sedative Agents
- CRISPR and Genetic Engineering
- Plant Virus Research Studies
- Anesthesia and Pain Management
- RNA Research and Splicing
- Therapeutic Uses of Natural Elements
- Healthcare cost, quality, practices
- Hemodynamic Monitoring and Therapy
- Soft tissue tumor case studies
- Collaboration in agile enterprises
- Thermography and Photoacoustic Techniques
- Heavy Metal Exposure and Toxicity
- Cardiac, Anesthesia and Surgical Outcomes
- Food Drying and Modeling
- Intensive Care Unit Cognitive Disorders
- Education and Work Dynamics
- Estrogen and related hormone effects
Mayo Clinic in Arizona
2023-2025
Hunan University of Traditional Chinese Medicine
2011-2024
Mayo Clinic
2024
The Ohio State University
2019-2022
University Radiology
2019
The Ohio State University Wexner Medical Center
2016
Center for Information Technology
2014
Hangzhou Vocational and Technical College
2003
Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important regulating CSC properties considered potential therapeutic targets. Here we report that miR-328-3p (miR-328) is significantly upregulated ovarian CSC. High expression miR-328 maintained by directly targeting DNA damage binding protein 2, which has been shown previously to inhibit Reduced activity ERK signaling CSC, mainly due low level reactive oxygen species, contributed...
Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved to treat recurrent ovarian cancer with BRCA1 or BRCA2 mutations, and as maintenance therapy for platinum-sensitive (BRCA wild-type mutated) after treatment platinum. However, the acquired resistance against PARPi remains a clinical hurdle. Here, we demonstrated that PARP inhibitor (olaparib)–resistant epithelial (EOC) cells exhibited an elevated aldehyde dehydrogenase (ALDH) activity, mainly contributed by increased...
Soybean isoflavones (SIs) are widely found in food and herbal medicines. Although the pharmacological activities of SIs have been reported, their effects on intestinal microecology normal hosts received little attention. Five-week-old Kunming (KM) mice were administered (10 mg/kg/day) for 15 days. Food intake, body weight, digestive enzyme activity measured. Small intestine microbiota, including lumen-associated bacteria (LAB) mucosa-associated (MAB), analyzed using 16S ribosomal ribonucleic...
Anesthesiologists are often tasked with overseeing sedation in non-surgical settings. We aim to determine whether adding adjuvant sedatives propofol affects the recovery times and complication rates after endoscopy. conducted a retrospective cohort study of adults (≥18) who received while undergoing Esophagogastroduodenoscopy (EGD) and/or Colonoscopy (COL) at large academic institution over four-year period. Patients receiving alone were compared against patients combination midazolam,...
Epithelial ovarian cancer is the most lethal malignancy of female reproductive tract. A healthy ovary expresses both Estrogen Receptor α (ERα) and β (ERβ). Given that ERα generally considered to promote cell survival proliferation, thereby, enhancing tumor growth, while ERβ shows a protective effect against development progression tumors, activation by its agonists could be therapeutically beneficial for cancer. Here, we demonstrate using newly developed agonist, OSU-ERb-12, can impede...
Rationale: Propofol is one of the first-line sedative-hypnotic agents for critically ill adults requiring mechanical ventilation. Although propofol can elevate triglyceride levels, and latter a risk factor pancreatitis, association between acute pancreatitis unclear. Objectives: We sought to determine clinical impact potential associations infusion, hypertriglyceridemia, pancreatitis. Methods: This an observational multicenter study (⩾18 yr old) who were admitted intensive care unit,...
Radiotherapy resistance is one of the major factors limiting efficacy radiotherapy in lung cancer patients. The extensive investigations indicate diversity mechanisms underlying radioresistance. Here, we revealed that DNA damage binding protein 2 (DDB2) a potential regulator radiosensitivity non-small cell (NSCLC) cells. DDB2, originally identified as recognition factor nucleotide excision repair, promotes survival and inhibits apoptosis NSCLC lines upon ionizing radiation (IR). Mechanistic...
Qiwei Baizhu Powder (QWBZP) is a traditional Chinese medicine formula for treating diarrhea induced by various causes. It elicits an anti-diarrheal effect regulating the gut microbiota (diversity, structure, and abundance). However, contribution of different components in QWBZP decoction to this remains unclear. In study, we used as reference standard investigate effects total glycosides (TGs) extracted from on bile acid metabolism mice with antibiotic-associated (AAD). The results 16S rRNA...
Aim The current study aimed to investigate the effects of Debaryomyces hansenii on diversity bacterial lactase gene in intestinal mucosa antibiotic-associated diarrhea (AAD) mice. Methods Eighteen mice were randomly divided into three groups (6 per group): healthy control group, model group and D. treatment group. was established by intragastric administration with a mixture cephradine gentamicin sulfate (23.33 mL·kg-1·d-1) twice day for 5 days continuously. After establishing AAD model,...
Cadmium (Cd) is a serious environmental pollutant to human health. Intestinal flora associated with This study probed into the effects of Cd on small intestinal mucosal in mice by drinking water intake 5 ppm, 20 ppm and 100 cadmium chloride for 50 days respectively. Results indicated that diversity, taxonomic composition community structure were influenced exposure. Sphingomonas, Microbacterium Desulfovibrio, as characteristic bacteria, played vital roles different dose groups Cd. Meanwhile,...
The gut microbiota (GM) is involved in the metabolism of glycosides and beneficial for enhancing their bioactivity. However, multi-glycosides by GM under normal pathological conditions unclear. In this study, total (TG) traditional Chinese medicine (TCM) formula Qiwei Baizhu Powder (QWBZP) were extracted to represent a multi-glycoside system. Ultra-high-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF-MS/MS) was used rapidly identify...
Qiwei Baizhu Powder (QWBZP) has been proven effective in treating antibiotic-associated diarrhea (AAD), and the mechanism is associated with regulating gut microbiota. However, role of bioactive compounds QWBZP microbiota still unclear. In this study, 24 mice were divided into a normal control group (N), model (R), decoction (TW), QWBZP-TG (TG). AAD mouse models established by mixed antibiotic administration. After modeling, TW TG treated QWBZP-TG, respectively. Mice N R gavaged sterile...
Toxic epidermal necrolysis (TEN) is a rare but often lethal drug reaction involving the skin. Treatment centered around suppurative care, and mortality rate remains unacceptably high, although clinical epidemiological features of TEN have been well documented for decades. Recent studies placed an emphasis on certain medications in pathophysiology severe TEN, our colleagues previously reported several cases improvement patients following hemodialysis. Here, we discuss major considerations...
Clinical guidelines have become an integral part of clinical care. We assessed professional society-based from 2012 to 2022 elucidate the trends in numbers documents, recommendations, and classes recommendations. Our results found that 40% do not follow all recommendations made by Institute Medicine for trustworthy documents. There has been a significant increase documents cardiology, gastroenterology, hematology/oncology. In addition, more than 20,000 there was variability different...
<div>Abstract<p>Cancer stem cells (CSC) play a central role in cancer metastasis and development of drug resistance. miRNA are important regulating CSC properties considered potential therapeutic targets. Here we report that miR-328–3p (miR-328) is significantly upregulated ovarian CSC. High expression miR-328 maintained by directly targeting DNA damage binding protein 2, which has been shown previously to inhibit Reduced activity ERK signaling CSC, mainly due low level reactive...
<p>microRNA expression assay, primers and antibodies used in this study, as well supplementary tables figures showing the relationship among miR328, ERK, ROS CSCs.</p>
<p>microRNA expression assay, primers and antibodies used in this study, as well supplementary tables figures showing the relationship among miR328, ERK, ROS CSCs.</p>
<div>Abstract<p>Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved to treat recurrent ovarian cancer with <i>BRCA1</i> or <i>BRCA2</i> mutations, and as maintenance therapy for platinum-sensitive (BRCA wild-type mutated) after treatment platinum. However, the acquired resistance against PARPi remains a clinical hurdle. Here, we demonstrated that PARP inhibitor (olaparib)–resistant epithelial (EOC) cells exhibited an elevated aldehyde...