A5025136502- Astrophysical Phenomena and Observations
- Gamma-ray bursts and supernovae
- Immune Cell Function and Interaction
- Astronomical Observations and Instrumentation
- Pulsars and Gravitational Waves Research
- T-cell and B-cell Immunology
- Pluripotent Stem Cells Research
- Immunotherapy and Immune Responses
- CRISPR and Genetic Engineering
- Immune cells in cancer
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Organ Transplantation Techniques and Outcomes
- Astrophysics and Cosmic Phenomena
- SAS software applications and methods
- Nuclear Physics and Applications
- Pancreatic function and diabetes
- High-pressure geophysics and materials
- Solar and Space Plasma Dynamics
- Statistical and numerical algorithms
- Particle Detector Development and Performance
- RNA Interference and Gene Delivery
- Mechanics and Biomechanics Studies
- Geophysics and Gravity Measurements
Hokkaido University
2011-2025
Nihon University Itabashi Hospital
2024
Sapporo Science Center
2023
St. Marianna University School of Medicine
2006-2011
RIKEN Center for Integrative Medical Sciences
2004-2008
RIKEN
2005-2007
Japan Science and Technology Agency
2006
Fujita Health University
2004
University of Tsukuba
1997-2001
Juntendo University
1997
Abstract The naked mole-rat (NMR, Heterocephalus glaber ), which is the longest-lived rodent species, exhibits extraordinary resistance to cancer. Here we report that NMR somatic cells exhibit a unique tumour-suppressor response reprogramming induction. In this study, generate NMR-induced pluripotent stem (NMR-iPSCs) and find NMR-iPSCs do not teratoma-forming tumorigenicity due species-specific activation of alternative reading frame ( ARF ) disruption mutation oncogene ES cell-expressed Ras...
Epidemiological studies have suggested that the recent increase in incidence and severity of immunoglobulin (Ig)E-mediated allergic disorders is inversely correlated with Mycobacterium bovis bacillus Calmette Guerin (BCG) vaccination; however, underlying mechanisms remain uncertain. Here, we demonstrate natural killer T (NKT) cells mice humans play a crucial role BCG-induced suppression IgE responses. BCG-activated murine Vα14 NKT cells, but not conventional CD4 selectively express high...
Abstract Vα14 NKT cells exhibit various immune regulatory properties in vivo, but their precise mechanisms remain to be solved. In this study, we demonstrate the of generation dendritic (DCs) by stimulation vivo. After repeated injection α-galactosylceramide (α-GalCer) into mice, splenic DCs acquired IL-10-dependent fashion, such as nonmatured phenotypes and increased IL-10 reduced IL-12 production. The unique cytokine profile these appears regulated ERK1/2 IκBNS. These also showed an...
Abstract It is well-documented that certain chemokines or their receptors play important roles in the graft rejection. However, of and maintenance transplantation tolerance remain unclear. In this study, we demonstrate blocking interaction between chemokine receptor, CXCR6, highly expressed on Vα14+ NKT cells its ligand, CXCL16, resulted failure to maintain thus induction acceleration a mouse transplant model, expression CXCL16 was up-regulated tolerated allografts, anti-CXCL16 mAb inhibited...
Significance A unique characteristic of invariant natural killer T ( i NKT) cells is their ability to immediately produce large amounts interferon-gamma (IFN-γ) upon activation, which enables these play critical roles in initiating immune responses various pathological conditions. In this study, we demonstrate a previously unidentified mechanism mediated by basic helix–loop–helix transcription factor family, member e40 (Bhlhe40) for accelerating IFN-γ production NKT cells. Bhlhe40 required...
Currently, most cell or tissue transplantations using induced pluripotent stem cells (iPSCs) are anticipated to involve allogeneic iPSCs. However, the immunological properties of iPSCs in an setting not well understood. We previously established a mouse transplantation model MHC-compatible/minor antigen-mismatched combinations, assuming hypoimmunogenic iPSC-setting. Here, we found that subcutaneously inoculated into MHC-compatible host mice resisted rejection and formed teratomas without...
The transmembrane chemokine CXCL 16 (CXCL16), which is the same molecule as scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX), has been shown to mediate chemotaxis adhesion of CXC 6-expressing cells such NKT activated Th1 cells. We generated SR-PSOX/CXCL16-deficient mice examined role this in vivo. mutant showed a reduced number liver cells, decreased production IFN-gamma IL-4 by administration alpha-galactosylceramide (alphaGalCer). Of note,...
Recently, accumulating evidence has suggested that tumors, including ovarian cancer, are composed of a heterogeneous cell population with small subset cancer stem cells (CSCs) sustain tumor formation and growth. The emergence drug resistance is one the most difficult problems in treatment which been explained recently by potential CSCs to have superior against anti-cancer drugs than conventional cells. In this study, we expanded line study examine whether phenomenon also observed clinical...
Background The cancer stem cell theory proposes that tumor formation in vivo is driven only by specific tumor-initiating cells having stemness; however, clinical trials conducted to test drugs target the stemness provided unsatisfactory results thus far. Recent studies showed clear involvement of immunity tumors; requirements tumor-initiation followed stable growth immunocompetent individuals remain largely unknown. Methods To clarify this, we used two similarly induced glioblastoma lines,...
In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these to transplantation has not been elucidated. We showed here depletion increased proliferative response CD4+ and cytotoxic lymphocyte induction CD8+ cells. Depletion recipient but donor before caused rejection. Furthermore, number population...
CD1d-restricted natural killer T (NKT) cells are a potential therapeutic target for cancer, which several clinical trials have already been reported. NKT specifically activated by synthetic glycolipid, alpha-galactosylceramide (alpha-GalCer). However, it is known that, in human cancer patients, express degree of hyporesponsiveness to alpha-GalCer. In this study, we examined the mechanism alpha-GalCer can be induced. cancer-bearing mice, alpha-GalCer-induced cell expansion, cytokine...