A5083739689- Dyeing and Modifying Textile Fibers
- Advancements in Transdermal Drug Delivery
- Skin Protection and Aging
- Hair Growth and Disorders
- Dermatology and Skin Diseases
- Lipid Membrane Structure and Behavior
- Amino Acid Enzymes and Metabolism
- Textile materials and evaluations
- melanin and skin pigmentation
- Ginseng Biological Effects and Applications
- Metabolism and Genetic Disorders
- Allergic Rhinitis and Sensitization
- Nutritional Studies and Diet
- Sphingolipid Metabolism and Signaling
- Surfactants and Colloidal Systems
- Dermatologic Treatments and Research
- Bee Products Chemical Analysis
- Pediatric health and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Nuclear Structure and Function
- Skin and Cellular Biology Research
- Hematological disorders and diagnostics
- Medicine and Dermatology Studies History
- Dietary Effects on Health
- Salivary Gland Disorders and Functions
Kao Corporation (Japan)
2008-2025
Osaka University
1957-1961
Cancer Institute (WIA)
1957
Significance The sphingolipid backbone ceramide is the major lipid species in stratum corneum and plays a pivotal function skin permeability barrier formation. Acylceramide an important epidermis-specific species. However, details of acylceramide production, including its synthetic genes, reactions their orders, intracellular site for have remained unclear. In present study, we identified cytochrome P450, family 4, subfamily F, polypeptide 22 (CYP4F22) as missing fatty acid ω-hydroxylase...
Abstract The incidence of dementia, a clinical symptom characterized by severe cognitive decline, is increasing worldwide. Predictive biomarkers are therefore required for early identification and management. D-amino acids in the brain contribute to function suggested as useful diagnosing dementia risk. To clarify their relationship with human we developed an method chiral metabolomics detecting slight differences amino acid amounts. Chiral tandem liquid chromatography-tandem mass...
Abstract Background Specific species of ceramides (Cer), major constituents lipids in the stratum corneum (SC), are decreased and correlated with SC barrier water-holding functions skin patients atopic dermatitis (AD) or psoriasis (Pso). However, possible correlations between Cer subclass ratios properties barrier-disrupted healthy remain unclear. The objective this study was to identify a new marker evaluate epidermal differentiation not only but also skin. Methods control subjects AD Pso...
Abstract Background The global prevalence of dementia is significantly increasing. Early detection and prevention strategies, particularly for mild cognitive impairment (MCI), are crucial but currently hindered by the lack established biomarkers. Here, we aimed to develop a high-precision screening method MCI combining D-amino acid profiles from peripheral blood samples with non-invasive subject information using nonlinear machine learning algorithms Methods A cross-sectional study was...
Abstract Coffee polyphenols (CPPs), including chlorogenic acid, exert various physiological activities. The purpose of this study was to investigate the effects CPPs on skin properties and microcirculatory function in humans. In double-blind, placebo-controlled study, 49 female subjects with mildly xerotic received either a test beverage containing (270 mg/100 mL/day) or placebo for 8 weeks. ingestion significantly lowered clinical scores dryness, decreased transepidermal water loss, surface...
Ceramides (CERs) play key roles in signal transduction and cell regulation, probably during the keratinization of human hair. Current methods using mass spectrometry (MS), however, are not sufficient to allow comprehensive analysis CER molecules, including isobaric isomeric CERs. Therefore, a method for profiling CERs was developed. The developed is based on reversed-phase liquid chromatography (RPLC) coupled atmospheric pressure chemical ionization (APCI)-MS. Comprehensive identification...
<i>Background:</i> Although it is well known that chemical oxidation with alkaline hydrogen peroxide damages human hair, little about the effects of bleaching during daily life activities which may alter hair components. <i>Objective:</i> To determine combined weathering on lipids and amino acids in hair. <i>Methods:</i> Levels were analyzed by chromatography scalp fibers collected from three different females experimentally treated...
Since ceramides (CERs) play roles in signal transduction and cell regulation, CERs of human hair might be responsible for apoptosis during keratinization, addition to their structural barrier water-holding functions. Although, we previously developed a method comprehensive profiling the hair, that was too insensitive quantitatively characterize small amount samples. The aim this study develop novel highly sensitive determination diverse CERs. is negative ion electrospray ionization mass...
A technology for the deposition of a persistent hydrophobicity to alkaline-color-treated weathered hair surfaces using 18-MEA (18-methyleicosanoic acid) is presented. Two approaches were examined in order make bind tightly surface. One was apply as an acid form and other salt or complex. It found that combination with specific cationic surfactants [stearoxypropyldimethylamine (SPDA) docosyldimethylamine (DSDA)] makes surface hydrophobic its maintained even after shampooing. Characterization...
Ethnic and racial differences in infant skin have not been well characterized. The purpose of this study was to establish whether there are ethnic similarities the stratum corneum (SC) functions Thai Chinese infants.Healthy infants 6 24 months age (N = 60; 30 Thai, Chinese) who resided Bangkok, Thailand, were enrolled. Transepidermal water loss (TEWL) SC hydration (capacitance) on thigh, buttock, upper arm measured. Ceramide content determined arm.SC remarkably different between two...
Hair lipid images, as visualized by argon sputter etching-scanning electron microscopy (ASE-SEM), reveal convex structures with a stitch pattern (SP) at the cell membrane complex (CMC) in transverse hair plane. Based on interindividual variation, different features of SP were classified into Types 0 to 4 corresponding scores 4. Observations using fibers collected from 27 Japanese females revealed significant positive correlations between and levels exogenous lipids, which suggests that...
The effect of the anteiso-branch moiety 18-MEA (18-methyleicosanic acid) to create a persistent hydrophobicity alkaline-color-treated weathered hair treated with 18-MEA/SPDA (stearoxypropyldimethylamine) was investigated by comparing straight-chain fatty acid (n-heneicosanoic acid, n-HEA) and an iso-branch (19-methyleicosanic 19-MEA) (18-MEA), using dynamic contact angle measurements, quantification LC/MS, temperature controlled atomic force microscopy (AFM). measurements indicated that is...
Chronic kidney disease (CKD) is highly prevalent in domestic cats. This study aimed to compare urinary D-amino acid levels between control and CKD-afflicted cats as a novel noninvasive method for assessing CKD. Cats were divided into CKD stage II groups accordance with the International Renal Interest Society guidelines. The DL-amino of analyzed using chiral tandem liquid chromatography-tandem mass spectrometry, their medical records investigated. group had considerably lower concentrations...
Accepted for publication February 20, 2008 Synopsis The variation of hair curvature in Japanese women was quantitatively investigated and the structure curved characterized with transmission electron microscopy (TEM) amino acid analysis. Two hundred thirty volunteers, aged from 10 to 70 years, were randomly selected. evaluation volunteers’ natural shape showed that 53% have straight hair, while remaining 47% (varying a slightly wavy frizzy style). average curl radius determined be 4.4 ± 2.3...
毛髪外観は毛髪の形や色，光学物性などの影響を受ける。たとえば，毛髪の形は加齢に伴いうねり(くせ)が強くなることが報告されているが，うねりの増加に起因して毛髪の揃いが乱れ，髪の艶が低下する。そこで本研究では毛髪の形に着目し，毛髪の形と微細構造との関係を明確にすることを目的とし，種々の解析を行い以下の結果を得た。1．蛍光色素のくせ毛内部への浸透挙動は非対称(くせ形状の外側で浸透速度が速く，内側で遅い)であった。この結果は外側・内側における構造／化学組成の違いを示唆する。2．透過型電子顕微鏡観察により，くせの外側では中間径フィラメント(IF)が螺旋状に配列し比較的小さなマクロフィブリルを形成し，くせの内側ではIFは毛髪軸にほぼ平行に配列し比較的大きなマクロフィブリルを形成する傾向が認められた。3．くせ毛を外側と内側に分割しアミノ酸組成を分析した結果，くせの外側にはAsp，Glu，Glyが多く，内側にはCysが多いことが判明した。以上のヒトのくせ毛解析結果は，羊毛のオルト／パラコルテックス細胞の解析結果に似ており，曲がった形の毛髪の構造や組成が哺乳類で共通である可能性を示唆する。
クロロゲン酸の降血圧効果を阻害する，コーヒー中の微量のヒドロキシヒドロキノン（HHQ）を定量するために，高速液体クロマトグラフ（HPLC）法を開発した．逆相でのHPLC/紫外検出（UVD）を用いたHHQの測定において，試料調製溶液及び移動相に0.1% wt リン酸0.1 mmol/L 1-ヒドロキシエタン-1,1-ジホスホン酸（HEDP）5% メタノール溶液（v/v）（pH 2.1）を用いることにより，標準のHHQを試料調製後の時間依存的な変化なしに安定に測定することが可能となった．コーヒー試料にて安定に測定するためには，陽イオン交換型の固相抽出を用いた前処理が有効であった．HHQの高感度検出にはHPLC/電気化学検出（ECD）を確立した（HPLC/UVDの検出下限0.05 μg/mLに対しHPLC/ECDでは0.001...
毛髪表面は18-MEA (18-メチルエイコサン酸) に覆われ，疎水的かつ低摩擦に保たれている。しかし，18-MEAはヘアカラーなどのアルカリ処理で容易に失われ，毛髪表面は親水化し摩擦は増大する。それは，毛髪の指通りや櫛通り，感触の悪化に影響すると考えられる。そこで，前述のようなダメージ実感を改善するため，18-MEAを表面に高吸着させることによる疎水性・低摩擦などの表面物性を回復させる技術開発を行い，18-MEAと特定の長鎖3級アミン (ステアロキシプロピルジメチルアミン：SPDA) の組み合わせにより，それが可能であることを見出した。その高吸着性のメカニズムを明らかにするため，18-MEAとSPDAから形成される吸着膜の解析を行った。その結果，その吸着膜はアルキルを外側に向けた状態で，表面を均一に覆い，18-MEAの末端の分子運動により最表面に液体状の相を形成することで，耐摩擦性を有することを見出した。さらに，18-MEAとSPDAを含有するコンディショナーの使用テストでは，滑らかな感触に加え，浮き毛や跳ね毛を減少させるなど，ヘアスタイルのまとまりをも向上する効果をもつことを見出した。
<sec> <title>BACKGROUND</title> Human health status can be measured on the basis of many different parameters. Statistical relationships among these parameters will enable several possible care applications and an approximation current individuals, which allow for more personalized preventive by informing potential risks developing interventions. Furthermore, a better understanding modifiable risk factors related to lifestyle, diet, physical activity facilitate design optimal treatment...