A5058458428- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Skin Protection and Aging
- Immune Cell Function and Interaction
- Heat shock proteins research
- Herpesvirus Infections and Treatments
- Mast cells and histamine
- Melanoma and MAPK Pathways
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Tuberous Sclerosis Complex Research
- Immune Response and Inflammation
- interferon and immune responses
- Invertebrate Immune Response Mechanisms
- Biochemical Analysis and Sensing Techniques
- Vascular Tumors and Angiosarcomas
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Inflammatory Myopathies and Dermatomyositis
- Histiocytic Disorders and Treatments
- Renal and related cancers
Northwestern University
2009-2025
Allegheny General Hospital
2025
University of Virginia
2024
Robert H. Lurie Comprehensive Cancer Center of Northwestern University
2019-2024
Loyola University Chicago
2011-2021
Bipar
2019
Data Harbor (United States)
2015
Loyola University Medical Center
2003-2014
University of Illinois Chicago
2010
Dynamic Systems (United States)
2010
During the 2011 International Pigment Cell Conference (IPCC), Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel experts, focused four topics: classification and nomenclature; definition stable disease; Koebner's phenomenon (KP); 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A emerged that segmental be...
The pathobiology of vitiligo has been hotly disputed for as long one remembers, and a magnet endless speculation. Evidently, the different schools thought--ranging, e.g. from concept that essentially is free-radical disorder to being primary autoimmune disease--imply very consequences best therapeutic strategies should adopt. As more effective therapy this common, often disfiguring pigmentary direly needed, we must strive harder settle pathogenesis debate definitively--on basis sound...
In human vitiligo, cutaneous depigmentation involves cytotoxic activity of autoreactive T cells. It was hypothesized that can progress in the absence regulatory cells (Treg). The percentage Treg among skin infiltrating evaluated by immunoenzymatic double staining for CD3 and FoxP3, revealing drastically reduced numbers non-lesional, perilesional lesional vitiligo skin. Assessment circulating pool FACS analysis CD4, CD25, CD127 FoxP3 expression, mixed lymphocyte reactions presence sorted...
Th17 cells are known to play a critical role in adaptive immune responses several important extracellular pathogens. Additionally, implicated the pathogenesis of autoimmune and inflammatory disorders as well cancer. Therefore, it is essential understand mechanisms that regulate differentiation. Notch signaling be at stages T cell development In this study, we report Notch1 activated both mouse human vitro-polarized blockade significantly downregulates production Th17-associated cytokines,...
Vitiligo can be reversed through immune targeting with mutant heat shock protein 70.
Vitiligo is a T-cell mediated skin disorder characterized by progressive loss of color. In individuals genetically predisposed to the disease, various triggers contribute initiation vitiligo. Precipitating factors can stress skin, leading activation and recruitment. Though hereditary are implicated in pathogenesis vitiligo, it unknown whether precipitating, stressful events play role To understand this, we utilized validated perceived scale (PSS) measure this parameter vitiligo patients...
Abstract It is now well established that cultured human melanocytes are capable of expressing immunologically important cell surface molecules and they can produce cytokines. Not all cells with the ability to express MHC class II effective Ag presentation. However, dendritic nature melanocytes, their strategic position within skin, phagocytic capacity seem suggest a role for these in processing presenting Ag. This study demonstrates normal skin present peptide Ag, process mycobacterial HSP65...
HSP70i and other stress proteins have been used in anti-tumor vaccines. This begs the question whether plays a unique role immune activation. We vaccinated inducible (Hsp70-1) knockout mice wild-type animals with optimized TRP-1, highly immunogenic melanosomal target molecule. were unable to induce robust lasting depigmentation Hsp70-1 mice, vivo cytolytic assays revealed lack of cytotoxic T-lymphocyte activity. Absence T-cell infiltration skin maintenance hair follicle melanocytes observed....
Vitiligo is an autoimmune skin disease characterized by melanocyte destruction. Regulatory T cells (Tregs) are greatly reduced in vitiligo skin, and replenishing peripheral Tregs can provide protection against depigmentation. Ganglioside D3 (GD3) overexpressed perilesional epidermal cells, including melanocytes, which prompted us to generate GD3-reactive chimeric antigen receptor (CAR) treat vitiligo. Mice received either untransduced or GD3-specific test the hypothesis that specificity...