A5004415872- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Viral gastroenteritis research and epidemiology
- Synthesis and Biological Evaluation
- Research in Cotton Cultivation
- Viral Infectious Diseases and Gene Expression in Insects
- Lymphoma Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Chronic Lymphocytic Leukemia Research
- melanin and skin pigmentation
- Cancer Research and Treatments
- Heat shock proteins research
- Immune cells in cancer
- Magnesium in Health and Disease
- Genomics, phytochemicals, and oxidative stress
- Extracellular vesicles in disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced biosensing and bioanalysis techniques
AbbVie (United States)
2020-2024
Loyola University Chicago
2023
Rutgers, The State University of New Jersey
2015-2022
Rutgers Cancer Institute of New Jersey
2015-2017
Johnson University
2014-2017
Northwestern University
2013-2015
Rush University
2015
Rush University Medical Center
2014-2015
Rutgers Sexual and Reproductive Health and Rights
2015
University of Chicago
2010-2013
Significance Immunotherapy has revolutionized cancer treatment, yielding unprecedented long-term responses and survival. However, a significant proportion of patients remain refractory, which correlates with the absence immune-infiltrated (“hot”) tumors. Here, we observed that FDA-approved unadjuvanted seasonal influenza vaccines administered via intratumoral injection not only provide protection against active virus lung infection, but also reduce tumor growth by increasing antitumor CD8 +...
Vitiligo can be reversed through immune targeting with mutant heat shock protein 70.
Abstract The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development and immune responses, has also been implicated tumorigenesis tumor survival. However, it is unknown whether for antitumor responses. We evaluated venetoclax, a selective small-molecule inhibitor of BCL2, would influence the activity checkpoint inhibitors (ICI). demonstrate mouse syngeneic models that venetoclax can augment efficacy ICIs accompanied by increase PD-1+ T effector memory cells....
Melanoma is one of the few types cancer with an increasing annual incidence. While a number immunotherapies for melanoma have been associated significant clinical benefit, including high-dose IL-2 and cytotoxic T lymphocyte antigen 4 (CTLA-4) blockade, response to either these single agents has limited 11-20% treated patients. Therefore, in this study, we sought test hypothesis that combination CTLA-4 blockade could mediate more profound therapeutic response.Here, B6 mice were challenged...
d-Amino acid analogs of peptides and proteins are attractive for applications in biotechnology medicine due to their reduced proteolytic sensitivity. Here, we report that self-assembling peptide nanofibers composed d-amino acids act as immune adjuvants, investigate ability induce antibody responses comparison l-amino counterparts. The model antigenic OVA (chicken egg ovalbumin aa 323–339) from chicken ovalbumin, known elicit mice, was linked an l- or domain generate enantiomeric displaying...
Abstract The activated B cell (ABC) subset of diffuse large B-cell lymphoma (DLBCL) is characterized by chronic receptor signaling and associated with poor outcomes when treated standard therapy. In ABC-DLBCL, MALT1 a core enzyme that constitutively stimulation the or gain-of-function mutations in upstream components pathway, making it an attractive therapeutic target. We discovered novel small-molecule inhibitor, ABBV-MALT1, potently shuts down selectively ABC-DLBCL preclinical models...
In this study, we demonstrate that engagement of two different natural killer receptors (NKRs) can lead to contrasting effects in the development self-reactive CD8+T cells and autoimmune vitiligo. Specifically, using a mouse model, show CD8+T-cell targeting melanocyte antigen, tyrosinase-related protein-1 (TRP-1) combination with delivery NKG2D ligands (Rae-1ϵ or H60), results strong responses against TRP-1 contrast, CD48, ligand for NKR 2B4, leads reduced formation TRP-1-reactive decreased...
A main goal of cancer immunology research is the formation Ag-specific memory T cell immunity capable activation upon tumor re-encounter. The requirements necessary to overcome inhibitory signals present in microenvironment and form such responses are unknown. In contrast previous studies targeting tumors expressing highly immunogenic model Ags, we demonstrate that alleviating tumor-induced suppression along with vaccination against authentic Ags during perioperative period provides...
CD8 T cells play a critical role in immunity against intracellular pathogens and cancer. A primary objective of cell-based vaccine strategies is the induction durable effective immune responses. Achieving this goal involves more than simply boosting numbers responding cells. Of particular interest with polycytokine capability, specifically ability to co-produce IFNγ, TNFα IL-2. The presence these polycytokine-producing correlates strongly protection foreign Therefore, approaches capable...
CD8(+) T cell responses have been shown to be regulated by dendritic cells (DCs) and CD4(+) cells, leading the tenet that play a passive role in their own differentiation. In contrast, using DNA vaccination model, separate events of from those priming, we demonstrate themselves, actively limit memory potential through cell-derived IFN-γ-dependent modification IL-12/IL-15Rα axis on DCs. Such cell-driven cytokine alterations result increased T-bet decreased Bcl-2 expression, thus progenitor...