A5102993239- Gut microbiota and health
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Smart Parking Systems Research
- Impact of Light on Environment and Health
- Alcohol Consumption and Health Effects
- Metabolomics and Mass Spectrometry Studies
- Building Energy and Comfort Optimization
- Barrier Structure and Function Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- Pregnancy-related medical research
- Statistical Methods in Clinical Trials
- Cell Adhesion Molecules Research
- Endoplasmic Reticulum Stress and Disease
- Prostate Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Food composition and properties
- Infant Nutrition and Health
- Cell Image Analysis Techniques
- CAR-T cell therapy research
- Cancer Research and Treatments
Rush University Medical Center
2018-2024
Toscana Life Sciences
2020-2022
Ca' Foncello Hospital
2016
University of Padua
2015-2016
Philips (Netherlands)
2015
University of Liverpool
1997-1999
Walton Centre
1997-1999
University of Birmingham
1992
Epidemiological studies propose a protective role for dietary fiber in colon cancer (CRC). One possible mechanism of is its fermentation property the gut and ability to change microbiota composition function. Here, we investigate mixture polyposis elucidate potential mechanisms using TS4Cre × cAPCl°x468 mice. Stool profiling was performed, while functional prediction done PICRUSt. short-chain fatty acid (SCFA) metabolites were measured. Histone acetylation expression SCFA butyrate receptor...
Significance Immunotherapy has revolutionized cancer treatment, yielding unprecedented long-term responses and survival. However, a significant proportion of patients remain refractory, which correlates with the absence immune-infiltrated (“hot”) tumors. Here, we observed that FDA-approved unadjuvanted seasonal influenza vaccines administered via intratumoral injection not only provide protection against active virus lung infection, but also reduce tumor growth by increasing antitumor CD8 +...
When advanced, oral squamous cell carcinoma (OSCC) may involve adjacent non-epithelial structures, and the prognosis is worse for bone invasion. Human relaxin-2 a peptide hormone that has recently been associated with cancer. It can induce human osteoclast differentiation activation, suggesting role in tumor-driven osteolysis. This study was preliminary assessment of prognostic surgical specimens OSCC tissue but uninvolved mandibular/maxillary bone.Relaxin-2 immunohistochemical expression...
We consider control of multiple luminaires with a central controller and occupancy light sensors co-located at the luminaires. The periodically provide local state illumination information to controller. Using this sensor feedback, determines dimming levels so as adapt artificial output changing daylight conditions, in an energy efficient way. propose multivariable feedback based on optimizing cost function component corresponding power consumption another errors sensors. constraints are...
Recent studies suggest that granulocytes (PMNs) play a role in the pathogenesis of acute and chronic myocardial ischemia extension injury. Granulocytes can release variety molecules mediating tissue injury which act synergistically with other cells. The aim our investigation was to evaluate granulocyte function patients affected by coronary artery disease (CAD) during angioplasty (PTCA). We studied 20 suffering from CAD. PMN's aggregating activity greater sinus than aorta (P < 0.01)....
Through a multitude of studies, the gut microbiota has been recognized as significant influencer both homeostasis and pathophysiology. Certain microbial taxa can even affect treatments such cancer immunotherapies, including immune checkpoint blockade. These impact processes individually well collectively through mechanisms from quorum sensing to metabolite production. Due this overarching presence in many physiological distal GI tract, we hypothesized that mice bearing tumors at...
Abstract Cancer is universally recognized as a heterogeneous disease. The different cell clones present in tumor can display distinct molecular and phenotypic profiles, which may influence proliferation capabilities, metastatic potential response to therapy. To better understand cancer progression possibly design effective therapeutic strategies, it fundamental cell-sorting technologies able isolate rare, viable from tissue or liquid biopsies. Fluorescence-activated sorting (FACS) the most...