A5049807771- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Virus-based gene therapy research
- Synthetic Organic Chemistry Methods
- Immune cells in cancer
- Fluorine in Organic Chemistry
- Renal Transplantation Outcomes and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced Polymer Synthesis and Characterization
- Renal Diseases and Glomerulopathies
- Chronic Kidney Disease and Diabetes
Rush University Medical Center
2015-2016
DePaul University
2015
Belden (United States)
2015
Rush University
2015
Melanoma is one of the few types cancer with an increasing annual incidence. While a number immunotherapies for melanoma have been associated significant clinical benefit, including high-dose IL-2 and cytotoxic T lymphocyte antigen 4 (CTLA-4) blockade, response to either these single agents has limited 11-20% treated patients. Therefore, in this study, we sought test hypothesis that combination CTLA-4 blockade could mediate more profound therapeutic response.Here, B6 mice were challenged...
Background . The PHS increased risk donor (IRD) is underutilized in liver transplantation. We aimed to examine the posttransplant outcomes recipients of increased-risk organs. Methods analyzed 228,040 transplants Organ Procurement and Transplantation Network database from 2004 2013. Endpoints were graft failure death. Results controlled for demographics comorbidities. Statistical analysis utilized Fisher’s test logistic regression. 58,816 patients identified (5,534 IRD, 53,282 non-IRD). IRDs...
Abstract Emerging epidemiological studies report increased cancer occurrence in patients with chronic viral infections, even when such infections are non-oncogenic and not the same tissue as cancer. In our recent studies, we observed decreased anti-tumor immune responses context of concomitant infection. Specifically, discovered that anti-melanoma (gp100) CD8+ T cell mice challenged melanoma shunted from tumor site (skin) to influenza infection (lung), leading faster growth hastened host...
Novel electrophilic trisubstituted ethylene monomers, halo ring-disubstituted 2-cyano-3-phenyl-2-propenamides, RPhCH = C(CN)CONH2, where R is 2,3-difluoro, 2,4-difluoro, 2,5-difluoro, 2,6-difluoro, 3,4-difluoro, 3,5-difluoro, 2-chloro-4-fluoro, 3-chloro-2-fluoro, 3-chloro-4-fluoro were prepared and copolymerized with styrene. The monomers synthesized by potassium hydroxide catalyzed Knoevenagel condensation of ring-substituted benzaldehydes cyanoacetamide, characterized CHN elemental...