A5064943761- melanin and skin pigmentation
- Psychoanalysis and Psychopathology Research
- History and Theory of Mathematics
- Philosophy, Science, and History
- Linguistics and Discourse Analysis
- Mathematical and Theoretical Analysis
- Philosophy and History of Science
- French Urban and Social Studies
- Philosophy and Theoretical Science
- Historical and Literary Studies
- Social Policies and Family
- Skin Protection and Aging
- Computability, Logic, AI Algorithms
- Atherosclerosis and Cardiovascular Diseases
- Quantum Mechanics and Applications
- Child and Adolescent Psychosocial and Emotional Development
- Philosophical and Theoretical Analysis
- Philosophy, Sociology, Political Theory
- Mast cells and histamine
- Biochemical Analysis and Sensing Techniques
- Classical Philosophy and Thought
- Olfactory and Sensory Function Studies
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- Education, sociology, and vocational training
Institute of Rural Management Anand
2022
Université de Montréal
2009-2019
Centre Hospitalier Universitaire de Bordeaux
2003-2019
Centre Hospitalier Universitaire Sainte-Justine
1995-2019
Hôpital Saint-André
2003-2019
Inserm
2006-2018
Université de Bordeaux
1975-2018
Laurentian University
1969-2018
Hôpital Pellegrin
1992-2014
Hôpital Cardiologique du Haut-Lévêque
2013
During the 2011 International Pigment Cell Conference (IPCC), Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel experts, focused four topics: classification and nomenclature; definition stable disease; Koebner's phenomenon (KP); 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A emerged that segmental be...
The aetiopathogenic mechanisms of vitiligo are still poorly understood, and this has held back progress in diagnosis treatment. Up until now, treatment guidelines have existed at national levels, but no common European viewpoint emerged. This guideline for the segmental nonsegmental been developed by members Vitiligo Task Force other colleagues. It summarizes evidence-based expert-based recommendations (S1 level).
The anterior and intermediate lobes of the pituitary gland derive from surface ectoderm. They provide a simple system to assess mechanisms developmental identity established by tissue determinants. Each lobe contains lineage expressing hormone precursor pro-opiomelanocortin (POMC): corticotropes melanotropes. T-box transcription factor Tpit controls terminal differentiation both lineages. We now report on unique role Pax7 as selector melanotrope identity. Inactivation gene results in loss...
In vitiligo, melanocytes are gradually lost in depigmented macules of the skin. The disappearance has, however, not been clearly observed and consequently aetiology disease (autoimmune, neural, cytotoxic) is still elusive. starting point vitiligo frequently determined by local conditions such as wounds excoriations, but may also follow minor traumas pressure or repeated friction. This prominent feature often neglected.To clarify biological consequences friction on attachment survival non...
Pigment Cell & Melanoma ResearchVolume 28, Issue 3 p. 363-369 Meeting Report Developing core outcome set for vitiligo clinical trials: international e-Delphi consensus Viktoria Eleftheriadou, Corresponding Author Eleftheriadou Centre of Evidence Based Dermatology, University Nottingham, UKCORRESPONDENCE Khaled Ezzedine and e-mails: khaled.ezzedine@chu-bordeaux.fr; viktoria.eleftheriadou@nottingham.ac.ukSearch more papers by this authorKim Thomas, Kim Thomas UKSearch authorNanja van Geel,...
Abstract Permanency planning is a critical issue facing all children in foster care. Foster frequently suffer from developmental delays and severe behavior problems, often leading to repeated displacements that turn increase the risk for attachment disorders. To prevent emergence of such disturbances, an Attachment Clinic was developed Montreal offer consultation Youth Protection workers. A specific problem has been identified this Clinic: Should child who significant his or her parents...
Using chimeric human epidermal reconstructs, we previously demonstrated that pigmentation is dependent upon the phototype of melanocytes. We report here several lines experimental evidence for dermal modulation pigmentation. First, II-III reconstructs grafted on back immunotolerant Swiss nu/nu mice developed a patchy presence colonizing or mouse fibroblasts. Similarly, white Caucasoid split-thickness skin xenografted same strain became black within 3 months and histochemistry revealed VI...
Dermatological practice in Martinique frequently encounters a bizarre skin condition presenting as progressive and extensive hypomelanosis on the back. The course of this disorder is highly characteristic: it occurs mainly females from 18-25 years age, with development round, pale, coalescent macules back sometimes abdomen. This disease, which does not respond to therapy, spontaneously regresses within 3 4 years. Decreased epidermal melanin only histological feature. Ultrastructural...
Common generalized vitiligo is an acquired depigmenting disorder characterized by a chronic and progressive loss of melanocytes from the epidermis hair follicles. We previously proposed new theory that involves detachment transepidermal caused autoimmune, neural impaired redox mechanisms associated with mechanical trauma. In this study, we reconstructed on dead de-epidermized dermis normal and/or non-segmental non-lesional (NSV) cells tested catecholamines or sera hydrogen peroxide. Under...
Although mixed forms have been described recently, segmental (SV) and nonsegmental vitiligo (NSV) are considered as clinically distinct. However, limited epidemiological data available to help distinguish associated factors, recent genome-wide association studies restricted NSV. The higher prevalence of SV in children is helpful when comparing the two major presentations disease.To compare factors with NSV, especially for markers autoimmunity or autoinflammation.We conducted a single-centre...
Background Until now, segmental vitiligo has been considered as a stable entity and mixed vitiligo, the association of nonsegmental reported rarely. Objectives The aim this study was to search for factors associated with generalization in patients vitiligo. Patients methods This prospective observational conducted clinic Department Dermatology Bordeaux, France. Vitiligo European Task Force questionnaire completed each patient attending confirmed diagnosis after exclusion other forms (focal,...
Background Unstable vitiligo lesions are usually considered to be contraindications for surgical treatment. Unfortunately, in the majority of common cases, neither accurate clinical signs nor routine blood tests available determine whether or not disease is active. Objectives To establish a direct correlation between aspect and their activity. Methods This was prospective observational study that took place over 1 year. For each patient, standardized evaluation included both careful daylight...
The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that 'repigmentation' and 'maintenance of gained repigmentation' are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these topics two sections includes atlas depicting repigmentation patterns color match. first section delineates mechanisms characteristics repigmentation, the second summarizes outcomes meeting discussions e-surveys on...
Background: Medical treatments are ineffective in many patients and surgical methods have therefore been developed.Objective: A review of autologous non-cultured melanocyte grafting techniques is proposed to obtain a successful repigmentation vitiligo macules.Methods: Initially 1992, we had developed simplified method which was carried out the following two steps: production blisters on depigmented lesions by freezing with liquid nitrogen injection each blister suspension epidermal cells.The...
Hypochromic vitiligo is a rare entity that has been reported only twice under the term 'vitiligo minor', with an absence of clear delineation.To delineate hypochromic through case series patients typical bilateral hypopigmented lesions affecting face and trunk.This retrospective multicentric evaluation study conducted in eight departments dermatology France, Belgium, Senegal Saudi Arabia.Twenty-four cases were identified. Fourteen men 10 women. The mean age at diagnosis was 35·4 years (range...
Abstract Background Segmental vitiligo and generalized are in general considered separate entities. However, clinico‐epidemiological data on segmental scarce compared with those of vitiligo. Objective To analyse the clinical profile distribution pattern lesions patients. Methods patients were examined questioned a prospective retrospective setting. The extent evaluated using photographs. Results Different phenotypes found, including unilateral type (124 patients; group 1), bilateral (three...
The combination of skin ablation and 5-Fluorouracil (5-FU) ointment was previously tried in the treatment vitiligo, good results were specifically reported glabrous without follicular melanocyte reservoirs. Methods. This study carried out on skins seven guinea pigs: three treated with mechanical dermabrasion plus topical 5-FU an achromic area contiguous to a pigmented area; two by only similar alone. Clinical, histological, ultrastructural studies performed over months. Results. In pigs...
Cette livraison spéciale de l'importante revue philosophique Philosophische Rundschau propose un tour d'horizon critique la « logique des sciences sociales. » L'auteur, professeur à l'Université Francfort, nous présente une synthèse magistrale l'epistémologie contemporaine sociales en deux cents pages d'un texte serré.