A5002742863- Veterinary Orthopedics and Neurology
- Spine and Intervertebral Disc Pathology
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- TGF-β signaling in diseases
- Musculoskeletal pain and rehabilitation
- Osteoarthritis Treatment and Mechanisms
- Veterinary Medicine and Surgery
- Veterinary Oncology Research
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Veterinary Equine Medical Research
- Cervical and Thoracic Myelopathy
- Inflammatory mediators and NSAID effects
- Anesthesia and Pain Management
- Orthopaedic implants and arthroplasty
- Bone fractures and treatments
- Medical Imaging and Analysis
- Tendon Structure and Treatment
- Elbow and Forearm Trauma Treatment
- Connective tissue disorders research
- Bone Tissue Engineering Materials
- Spinal Fractures and Fixation Techniques
- Virus-based gene therapy research
- Knee injuries and reconstruction techniques
Utrecht University
2015-2024
Ministry of Agriculture, Nature and Food Quality
2021
Netherlands Food and Consumer Product Safety Authority
2021
Wageningen University & Research
2021
University of Bologna
2014-2019
Veterinary Oncological Center
2019
Swedish University of Agricultural Sciences
2011
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007
ISA Pharmaceuticals (Netherlands)
2006
Chiang Mai University
2006
Object. Pituitary adenomas are considered benign tumors; however, they may infiltrate surrounding tissues including the dura mater. In this paper authors analyze clinical significance of microscopically confirmed dural invasion by comparing a range variables (age and sex patients, adenoma type, size on magnetic resonance [MR] images, remission, residual pituitary disease, recurrence, survival, disease-free interval after surgery) between patients with noninvasive those invasive ones....
Negative feedback regulation of the proopiomelanocortin (POMC) gene by glucocorticoid (Gc) receptor (GR) is a critical feature hypothalamo-pituitary-adrenal axis, and it in part exerted trans-repression between GR orphan nuclear receptors related to NGFI-B. We now show that Brg1, ATPase subunit Swi/Snf complex, essential for this Brg1 required vivo stabilize interactions NGFI-B as well HDAC2. Whereas constitutively present at POMC promoter, recruitment HDAC2 ligand-dependent results histone...
Prospective observational and analytic study.To investigate whether spontaneous intervertebral disc degeneration (IVDD) occurring in both chondrodystrophic (CD) nonchondrodystrophic dogs (NCD) can be used as a valid translational model for human IVDD research.Different animal models are research, but most of these is induced manually or chemically rather than spontaneously.A total 184 discs (IVDs) from 19 different breeds were used. The extent was evaluated by macroscopic grading,...
Abstract Objective —To determine the incidence and distribution of intervertebral disk (IVD) degeneration–related diseases in a large population dogs various breeds, ages, sexes to mortality rates among with these diseases. Design —Epidemiological study. Sample —Insurance data for veterinary health-care life insurance coverage (n = 665,249 552,120, respectively). Procedures claim records 1 company Sweden were searched identify IVD diseases; determined affected < 12 years old 10 old,...
The anterior and intermediate lobes of the pituitary gland derive from surface ectoderm. They provide a simple system to assess mechanisms developmental identity established by tissue determinants. Each lobe contains lineage expressing hormone precursor pro-opiomelanocortin (POMC): corticotropes melanotropes. T-box transcription factor Tpit controls terminal differentiation both lineages. We now report on unique role Pax7 as selector melanotrope identity. Inactivation gene results in loss...
The medical records of 156 dogs with degenerative lumbosacral stenosis (DLS) that underwent decompressive surgery were reviewed for signalment, history, clinical signs, imaging and surgical findings. German Shepherd Dog (GSD) was most commonly affected (40/156, 25.6%). Pelvic limb lameness, caudal lumbar pain evoked by pressure the frequent Radiography showed step formation in 78.8% (93/118) which associated elongation sacral lamina 18.6% (22/118). Compression cauda equina diagnosed...
Abstract Objective —To assess whether the Pfirrmann system for grading lumbar intervertebral disk (IVD) degeneration in humans can also be used dogs. Animals —202 Procedures —Magnetic resonance imaging was to obtain images of vertebral segments from dogs, which were reviewed separately by 3 observers who graded extent each visible IVD use classification humans. Grading validated against 2 factors associated with degeneration: type dog (chondrodystrophic or nonchondrodystrophic breeds) and...
Early degeneration of the intervertebral disc (IVD) involves a change in cellular differentiation from notochordal cells (NCs) nucleus pulposus (NP) to chondrocyte-like (CLCs). The purpose this study was investigate gene expression profiles involved process using NP tissue non-chondrodystrophic and chondrodystrophic dogs, species with naturally occurring IVD degeneration.Dual channel DNA microarrays were used compare 1) healthy containing only NCs (NC-rich), 2) mixed population CLCs (Mixed),...
Low back pain, related to degeneration of the intervertebral disc (IVD), affects millions people worldwide. Clinical studies using oral cyclooxygenase-2 (COX-2) inhibitors have shown beneficial effects, although side-effects were reported. Therefore, intradiscal delivery nonsteroidal anti-inflammatory drugs can be an alternative treatment strategy halt and address IVD-related pain. In present study, controlled release biologic potency celecoxib, a selective COX-2 inhibitor, from...
Objective —To evaluate microsurgical transsphenoidal hypophysectomy in dogs with pituitary‐dependent hyperadrenocorticism (PDH). Study Design —Prospective study to the results (survival and disease‐free interval, remission, recurrence) complications of by clinical follow‐up, computed tomography (CT), urinary corticoid‐to‐creatinine (C/C) ratios PDH. The effect surgical experience was investigated comparing cases 1 through 26 27 52. Animals or Sample Population—52 Results —Preoperative CT...
Objective To assess pedicle screw‐rod fixation ( PSRF ) of the canine lumbosacral junction LSJ ex vivo and in . Study Design Ex cadaver study pilot study. Sample Population Six cadaveric spinal specimens 3 Greyhound dogs diagnosed with degenerative stenosis DLSS ). Methods study: was performed 6 using guidelines evaluated by radiography, computed tomography, magnetic resonance imaging. In Greyhounds had dorsal laminectomy partial discectomy combined Curettage endplates insertion an...
Abstract The notochordal cell (NC) of the nucleus pulposus (NP) is considered a potential NP progenitor cell, and early intervertebral disk (IVD) degeneration involves replacement NCs by chondrocyte‐like cells (CLCs). Wnt/β‐catenin signaling plays crucial role in maintaining fate during embryogenesis, but also involved tissue regeneration. canine species, which can be subdivided into non‐chondrodystrophic chondrodystrophic breeds, characterized differential maintenance NC: dogs, NC remains...
Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration inflammation are significant components of the pathological cascade. Only limited studies have studied cytokine chemokine profiles IVD dogs, mainly focused on gene expression. A better understanding needed order to develop biological therapies that address both pain disease. Therefore, this study, we determined levels prostaglandin E2 (PGE2), cytokines, chemokines, matrix IVDs from chondrodystrophic (CD)...
Degenerative lumbosacral stenosis is a common problem in large breed dogs. For severe degenerative stenosis, conservative treatment often not effective and surgical intervention remains as the last option. The objective of this retrospective study was to assess middle long term outcome with pedicle screw-rod fixation or without evidence radiological discospondylitis. Twelve client-owned dogs underwent junction. During follow-up, were monitored by clinical evaluation, diagnostic imaging,...
Background Transsphenoidal hypophysectomy is one of the treatment strategies in comprehensive management dogs with pituitary‐dependent hypercortisolism ( PDH ). Objectives To describe influence pituitary size at time gland surgery on long‐term outcome. Animals Three‐hundred–and‐six . Methods Survival and disease‐free fractions were analyzed related to size; without recurrence compared. Results Four weeks after surgery, 91% alive remission was confirmed 92% these dogs. The median survival 781...