A5088831645- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Occupational exposure and asthma
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Herpesvirus Infections and Treatments
- Dermatology and Skin Diseases
- Cytomegalovirus and herpesvirus research
- Skin Protection and Aging
- melanin and skin pigmentation
- Synthesis and properties of polymers
- Cancer and Skin Lesions
- Biopolymer Synthesis and Applications
- Biosensors and Analytical Detection
- Biotin and Related Studies
- Nail Diseases and Treatments
- Urticaria and Related Conditions
- Cutaneous Melanoma Detection and Management
- Viral-associated cancers and disorders
- Rabies epidemiology and control
- Cutaneous lymphoproliferative disorders research
- Melanoma and MAPK Pathways
- Acne and Rosacea Treatments and Effects
- Advanced Power Generation Technologies
- Inflammasome and immune disorders
Fujita Health University
2008-2023
Fujita Health University Hospital
1999-2021
Tokyo Medical and Dental University
1973-2019
Kariya Toyota General Hospital
2007-2017
University of Toyama
2017
Advanced Dermatology
2001-2017
Toyota Motor Corporation (Switzerland)
2011-2015
Tokai Central Hospital
2004-2005
Juntendo University Hospital
2005
Showa Pharmaceutical University
2003
Primers for herpes simplex virus type 1 (HSV 1)-specific loop-mediated isothermal amplification (LAMP) method amplified HSV-1 DNA, while HSV-2-specific primers only HSV-2 DNA; no LAMP products were produced by reactions performed with other viral DNAs. The sensitivities of the HSV-1- and methods, determined agarose gel electrophoresis, reached 500 1,000 copies/tube, respectively. turbidity assay, however, sensitivity methods to be 10,000 After initial validation studies, 18 swab samples (in...
Abstract Because some users develop depigmentation after the use of melanogenesis‐inhibiting products containing quasi‐drug ingredient Rhododenol, Japanese Dermatological Association (JDA) established a Special Committee on Safety Cosmetics Containing Rhododenol July 17, 2013 and management guide for dermatologists has been updated website in order to delineate diagnostic criteria Rhododenol‐induced leukoderma provides broad standard treatment based current knowledge. This is produced basis...
Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the color carminic acid (CA). Carmine an aluminum- or calcium-chelated product CA. CA carmine usually contain contaminating proteins, including 38-kDa protein thought to be primary allergen. Severe allergic reactions manifest anaphylaxis. aim this study was review all Japanese reported cases propose useful diagnostic chart.All cochineal dye-induced immediate allergy...
The reliability of varicella-zoster virus (VZV) loop-mediated isothermal amplification (LAMP) was evaluated for rapid diagnosis viral infection. VZV-specific primers only amplified VZV DNA; no LAMP products were observed in reactions performed with other DNA templates. specificity this method confirmed by two independent determinations, agarose gel electrophoresis and a turbidity assay. sensitivity LAMP, determined electrophoresis, 500 copies/tube. Detection using the assay, however, gave...
We examined the excretion of varicella zoster virus (VZV) in hospitalized patients with herpes localized to thoracic region whose skin lesions were covered either hydrocolloid dressing agents (hydrocolloid group) or conventional gauze bandages (gauze group). The presence VZV DNA swab samples from lesion coverings, throat, and filters air purifiers was by use a sensitive polymerase chain reaction assay. For group, detected none coverings purifier filters; for all 6 patients. less frequently...
Clock genes encoding transcription factors that regulate circadian rhythms may inform chronomodulated chemotherapy, where time-dependent dose alterations might affect drug efficacy and reduce side effects. For example, inhibiting the essential cystine transporter xCT with sulfasalazine induces growth arrest in cancer cells. Although anticancer effects of have been studied extensively, its on transcriptional control expression not studied. Here, we show administration during period increased...
Acne vulgaris (acne) and cutaneous resident microorganisms are considered to be closely related. However, the bacterial fungal microbiota in comedonal contents of inflammatory acne lesions have not yet been investigated detail.To clarify relationship between acne, we examined microbiome on facial skin patients with using 16s rRNA ITS gene sequencing a next-generation sequencer (NGS).Twenty-two untreated Japanese outpatients were examined. The face collected comedo extractor. Skin surface...
Natural rubber latex (NRL) allergy is a common occupational disease in health care workers (HCW). However, few reports have compared the major allergen of HCWs to those gloves that are routinely used hospital. The aim this study was evaluate NRL allergens by HCWs. We studied 20 who were suspected (LA). performed skin prick test (SPT) using allergens. Serological testing ImmunoCAP™. total amount protein and antigenic concentrations extracted from measured. Four different types FITkit™ measure...
ABSTRACT We report a 22‐year‐old woman with urticaria, dyspnea and bronchial asthma‐like attacks after eating curried rice. found the symptoms to be due an immediate‐type allergy caused by spice antigens contained in curry spices detailed questioning, skin test measurement of specific immunoglobulin (Ig)E antibodies. This case was complicated pollen‐food syndrome (PFAS) from melon latex (LA) natural rubber (NRL) antigen she had also atopic dermatitis, allergic rhinitis pollinosis. Serum IgE...
Myo-inositol phosphate intermediates formed during dephosphorylation of phytic acid (by rice bran phosphatase with phytase activity F2) were isolated by ion-exchange chromatography. Hydrolysis proceeded via L-myo-inositoI 1, 2, 3, 4, 5 and D-myo-inositol 5, 6-pentakisphosphate, 6 L-myo-inositol 4-tetrakisphosphate, D-myoinositol myo-inositol 3-trisphosphate, 2-bisphosphate finally myoinositol monophosphate (myo-inositol 93%; 7%). Six percent 85% Pi found in the reaction mixture when...
In recent years, it has been proposed that the primary mechanism for development of food allergies is percutaneous sensitization. Since 2010, in Japan, number immediate-type wheat allergy due to hydrolyzed protein dramatically increased among those who have using soap containing wheat. This incidence supports hypothesis allergens arise through sensitization.A 25-year-old man (case 1) and an 18-year-old girl 2) with atopic dermatitis visited our Department because hand eczema. After starting...
Background The proportion of positive test results with gold sodium thiosulfate included in a patch panel (P‐GST) had been found to be greater than that 0.5% pet. by allergEAZE (A‐GST). Objectives To compare reactions P‐GST and A‐GST, evaluate late after the day (D) 7 reading. Methods A retrospective analysis was performed 588 patients at participating departments (119 males; 469 females) who were tested A‐GST May 2015 March 2016. Results Positive observed 15% 6% patients, respectively....
Loop-mediated isothermal amplification (LAMP) is a nucleic acid method with high specificity, efficiency and speed. No reports exist regarding the usefulness of LAMP for clinically suspected skin infections caused by herpes simplex virus (HSV) or varicella zoster (VZV). The aim this study was to evaluate clinical in diagnosis common cutaneous alpha herpesvirus (HSV type 1 2, VZV) infections. real-time polymerase chain reaction (PCR) were performed using swab samples collected from 106...
A 16-year-old girl presented with a 9-year history of vesicles on the vulva. She had initially taken wait-and-see approach, but required treatment because bleeding. Histological examination biopsied vesicle revealed dilated lymph channels in upper dermis, suggesting lymphangioma circumscriptum (LC). The challenge for this pathology has been to find conservative low morbidity and better results than those reported surgical excision, which mainstay therapy. In case, LC vulva was successfully...
The Japanese baseline series (JBS), established in 1994, was updated 2008 and 2015. JBS 2015 is a modification of the thin-layer rapid-use epicutaneous (TRUE) test (SmartPractice Denmark, Hillerød, Denmark). No nationwide studies concerning TRUE have previously been reported.To determine prevalence sensitizations to allergens from 2018.We investigated patch results using web-registered Skin Safety Care Information Network (SSCI-Net) April March 2019.Patch 5865 patients were registered 63...
Immediate allergy caused by natto, a popular Japanese food prepared fermenting soybeans with Bacillus subtilis var. has been reported. Polygamma glutamic acid (PGA) in the sticky substance around natto beans reported to be causative allergen of allergy. However, some our patients were negative for PGA skin prick test (SPT). The contains subtilisin family serine protease, nattokinase, along PGA. In this study, we aimed examine antigenicity nattokinase allergy.Eight patients, who developed...
Screening for ω-5 gliadin specific IgE antibody (sIgE) has high diagnostic utility in cases of suspected wheat-dependent exercise-induced anaphylaxis (WDEIA); however, negative may require confirmatory tests, such as the oral challenge test. Thus, newly identified allergens that can be used serological diagnosis WDEIA are needed. This study aimed to identify additional sIgE biomarkers WDEIA.Forty-two patients with (5 negative/37 positive sIgE) were enrolled. For comparison, 8 immediate-type...