A5063087094- Food Allergy and Anaphylaxis Research
- Contact Dermatitis and Allergies
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- RNA and protein synthesis mechanisms
- Asthma and respiratory diseases
- Transgenic Plants and Applications
- RNA modifications and cancer
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Eosinophilic Esophagitis
- Biochemical and Molecular Research
- Peptidase Inhibition and Analysis
- Biopolymer Synthesis and Applications
- Systemic Lupus Erythematosus Research
- Mycobacterium research and diagnosis
- dental development and anomalies
- Gastric Cancer Management and Outcomes
- DNA and Nucleic Acid Chemistry
- Mass Spectrometry Techniques and Applications
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Dermatology and Skin Diseases
- Monoclonal and Polyclonal Antibodies Research
- Animal health and immunology
Research & Development Institute
2014-2025
Fujita Health University
2016-2025
Japanese Foundation For Cancer Research
2023-2025
Toyota Central Research and Development Laboratories (Japan)
2015-2024
Fujita Health University Hospital
2015
Hoyu (Japan)
2009-2010
Gifu University
2006-2010
Soka University of America
2009
Temasek Life Sciences Laboratory
2008
National University of Singapore
2008
Cochineal dye is used worldwide as a red coloring in foods, drinks, cosmetics, quasi-drugs, and drugs. The main component of the color carminic acid (CA). Carmine an aluminum- or calcium-chelated product CA. CA carmine usually contain contaminating proteins, including 38-kDa protein thought to be primary allergen. Severe allergic reactions manifest anaphylaxis. aim this study was review all Japanese reported cases propose useful diagnostic chart.All cochineal dye-induced immediate allergy...
403 Background: The combination of docetaxel + S-1 (DS) therapy in postoperative adjuvant treatment for gastric cancer has proven to be effective and become a standard therapy. Clarification factors involved the timing non-adherence is important minimize non-adherence. Methods: Among 92 patients who started DS as chemotherapy between November 1, 2015 April 30, 2021 at Cancer Institute Hospital Japanese Foundation Research, 90 were eligible this study. adherence rate per cycle was defined...
Ostrich antibodies have a cost advantage over derived from small animals and are commercially used in diagnostic reagents. They also expected to be effective preventing infection, products containing them, such as cosmetics, available on the market. We encountered two cases of egg allergy adult women after using cosmetics ostrich yolk extract which this antibody was applied. Case 1: 44-year-old woman who consumed Japanese pizza with semi-cooked eggs experienced eyelid swelling, abdominal...
The specific aminoacylation of tRNA by tyrosyl-tRNA synthetases (TyrRSs) relies on the identity determinants in cognate tRNA(Tyr)s. We have determined crystal structure Saccharomyces cerevisiae TyrRS (SceTyrRS) complexed with a Tyr-AMP analog and native tRNA(Tyr)(GPsiA). Structural information for TyrRS-tRNA(Tyr) complexes is now full-line three kingdoms. Because archaeal/eukaryotic TyrRSs-tRNA(Tyr)s pairs do not cross-react their bacterial counterparts, recognition modes TyrRSs were...
Streptomyces griseus produced a certain kind of flocculating substance(s). The substance(s) could aggregate suspended kaolin particles in solution to form small floes and enables it sediment those particles. production by S. was not parallel the cell growth large number released into culture broth death phase. acted under acidic conditions maximum activity observed at pH 4.
Journal Article Site-selective Post-translational Modification of Proteins Using an Unnatural Amino Acid, 3-Azidotyrosine Get access Satoshi Ohno, Ohno * 1Department Biomolecular Science, Faculty Engineering; 2Division Regeneration and Advanced Medical Graduate School Medicine, Gifu University, Yanagido 1-1, 501-1193; 3Institute for Comprehensive Fujita Health Toyoake, Aichi 470-1192, Japan *To whom correspondence should be addressed. Tel: +81-58-293-2645, Fax: +81-58-230-1893, E-mail:...
Elevated expression of interleukin (IL)-18 mRNA and protein in intestinal mucosa, attributable to activated monocytes macrophages that site, has been reported patients with inflammatory bowel disease (IBD). However, changes serum IL-18 concentrations IBD have not reported. We measured bioactive from IBD, using an enzyme-linked immunosorbent assay (ELISA). Mean 5 Crohn (CD) were 400 pg/mL, approximately 1.7 times higher than 21 control subjects (p < 0.01). was increased ulcerative colitis...
Background: Immediate-type wheat allergy caused by a specific hydrolyzed protein (HWP-IWA), Glu- pearl 19S (GP19S), typically develops food-dependent exercise-induced anaphylaxis (FDEIA), but is different from conventional FDEIA, or simple in many aspects. The skin prick test (SPT) considered to be the most effective method for diagnosis of HWP-IWA. As SPT relatively qualitative method, we developed quantitative and high-throughput Methods: An enzyme-linked immunosorbent assay (ELISA)-based...
In Japan, over 2000 users of a facial soap containing Glupearl 19S (GP19S), hydrolysed wheat protein (HWP), developed immediate-type systemic allergy (HWP-IWA), and ∼70% them associated contact urticaria.We investigated whether HWP-IWA patients cross-react with other HWPs, analysed HWP antigenic characteristics.We used 10 types that are commercially available as cosmetic ingredients, 16 subjects HWP-IWA. We performed an enzyme-linked immunosorbent assay (ELISA) to evaluate the reactivity...
Immediate allergy caused by natto, a popular Japanese food prepared fermenting soybeans with Bacillus subtilis var. has been reported. Polygamma glutamic acid (PGA) in the sticky substance around natto beans reported to be causative allergen of allergy. However, some our patients were negative for PGA skin prick test (SPT). The contains subtilisin family serine protease, nattokinase, along PGA. In this study, we aimed examine antigenicity nattokinase allergy.Eight patients, who developed...
Screening for ω-5 gliadin specific IgE antibody (sIgE) has high diagnostic utility in cases of suspected wheat-dependent exercise-induced anaphylaxis (WDEIA); however, negative may require confirmatory tests, such as the oral challenge test. Thus, newly identified allergens that can be used serological diagnosis WDEIA are needed. This study aimed to identify additional sIgE biomarkers WDEIA.Forty-two patients with (5 negative/37 positive sIgE) were enrolled. For comparison, 8 immediate-type...
Background: Serological testing for immunoglobulin (Ig) E or IgG is useful diagnosing allergic bronchopulmonary aspergillosis (ABPA), as it detects type I and III reactions to Aspergillus species. However, few reports have investigated the allergen component cross-reactivity among We aimed measure analyze levels of IgGs specific each species investigate prevalence IgEs A. fumigatus (Af) in ABPA patients.Methods: Serum samples were collected from 12 patients who visited our hospital between...
We report the second case of neonatal alloimmune thrombocytopenia due to anti-human platelet antigen (HPA)-3b (Bak(b)) antibody. The infant was severely affected with intracranial haemorrhage. Most importantly, we were able detect this antibody only by using fresh, unfixed platelets as antigen. This detectable neither conventional mixed passive haemagglutination, immunofluorescence test fixed platelets, nor monoclonal immobilization assay solubilized platelets. assume that reacts fresh and...
Abstract We report here a case of immediate hypersensitivity to beer, in which female patient developed angioedema the eyelids shortly after consuming beer. In skin prick tests, showed positive reactions base ingredients particularly malt and barley. The specific serum immunoglobulin E antibodies against barley displayed weakly reactivity. To identify immunoreactive antigens, proteins were separated by 2‐D polyacrylamide gel electrophoresis immunoreacted with patient's serum. results mass...