A5025803389- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Myasthenia Gravis and Thymoma
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Thyroid and Parathyroid Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cytomegalovirus and herpesvirus research
- Medical Imaging and Pathology Studies
- Polyomavirus and related diseases
- Congenital Diaphragmatic Hernia Studies
- T-cell and B-cell Immunology
- Mechanical Circulatory Support Devices
- Immune Response and Inflammation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Airway Management and Intubation Techniques
- Trauma Management and Diagnosis
- Meningioma and schwannoma management
- Tuberous Sclerosis Complex Research
German Center for Lung Research
2024-2025
Medizinische Hochschule Hannover
2011-2025
Osaka International Cancer Institute
2018-2024
Osaka University
2007-2021
Osaka Medical Center for Cancer and Cardiovascular Diseases
2002-2015
Kure Medical Center
2007
National Hospital Organization
2007
Takarazuka City Hospital
2001-2005
Although video-assisted thoracoscopic thymectomy (VATS-Tx) for thymoma has been introduced, its oncological outcome remains unclear. Our institutional experience with early-stage was retrospectively reviewed to evaluate the feasibility of thymectomy.A retrospective review consisting 74 patients Masaoka Stage I and II thymomas who had undergone performed. Forty-five underwent thymectomy, while 29 through open sternotomy approach. The clinical factors associated surgical outcome, including...
Most patients suffering from cancer die of metastatic disease. Surgical removal solid tumors is performed as an initial attempt to cure patients; however, surgery often accompanied with trauma, which can promote early recurrence by provoking detachment tumor cells into the blood stream or inducing systemic inflammation both. We have previously reported that administration atrial natriuretic peptide (ANP) during perioperative period reduces inflammatory response and has a prophylactic effect...
The IL-6-amplifier first was discovered as a synergistic activation mechanism for NF-κB/STAT3 in type 1 collagen(+) cells. This process is marked by the hyperinduction of chemokines and subsequent local inflammation that leads to autoimmune diseases. In this study, we show IL-6 amplifier grafts plays important roles allogeneic graft rejection using tracheal heterotopic transplantation model includes bronchiolitis obliterans, pathological marker chronic rejection. IL-6, epidermal growth...
Introduction: Lung volume reduction surgery (LVRS) is an important treatment option for patients with advanced emphysema and typically performed in a non-anatomical fashion. This study reports the outcome of anatomical LVRS by means uniportal video-assisted thoracoscopic (VATS). Methods: We retrospectively evaluated who underwent between June 2017 September 2023 at our institution. Patient characteristics, including demographic data, lung function, as well morbidity mortality were extracted...
Regulatory T cells (Treg) can regulate alloantigens and may counteract chronic lung allograft dysfunction (CLAD) in transplantation. We analyzed Treg peripheral blood prospectively correlated percentages of subpopulations with the incidence CLAD at 2 years. Among lung-transplanted patients between January 2009 July 2011, only sufficient measurements were included into study. Tregs measured immediately before transplantation, 3 weeks 3, 6, 12, 24 months after transplantation defined as CD4+...
Objective: The presence of isolated tumor cells (ITCs) in the pulmonary vein (PV) a lung resected for cancer has been reported to be prognostic factor. Previous investigations noted correlations between prognosis and or amount ITCs, although few studies have investigated clinical implications morphological characteristics those cells. We assessed ITCs PV using novel enrichment approach that maintained their characteristics. Methods: Ninety-four consecutive patients with primary...
Abstract The IL-6 amplifier, a positive feedback loop for NFκB signaling, which was originally found to be activated by IL-17A and stimulation in non-immune cells, is molecularly simultaneous activator of signal transducer transcription 3 (STAT3), functionally local chemokine inducer pathologically machinery inflammation development. It has been shown that amplifier activation epithelial cells contributes rejection responses mouse chronic model develops bronchiolitis obliterans (BO)-like...
Background. Recently, it has been reported that Th17 contributes to allograft rejection after transplantation. We investigated the alteration of and regulatory T cells (Treg) distribution in an animal model bronchiolitis obliterans following ectopic tracheal transplantation model. Methods. Tracheal grafts from B6 mice transplanted into subcutaneous sites C3H mice. Allografts were histologically evaluated, expressions CD4, CD8, CD25, CD28, CD127, CD152 Foxp3, intracellular interleukin (IL)-4,...
Thymoma-associated multi-organ autoimmunity is a rare, autoimmune disease that causes colitis, liver dysfunction and cutaneous graft-versus-host (GVH)-like skin damage. This paraneoplastic disorder may be due to inadequate T cell selection in the tumour environment of thymus. Although sporadic case reports have revealed its clinical features, little known about pathological mechanism. By comparing skin-infiltrating subsets with those GVH (GVHD) other inflammatory diseases, we sought...
Optimal surgical treatment for patients with stage IIIA N2 non-small cell lung cancer (NSCLC) remains a matter of debate, because the outcomes. The outcomes may be affected from variations in patterns lymph node metastasis. As sub-classifications, multiple station metastases mediastinal nodes (MN2), highest metastasis (HM), distribution metastatic (skip or non-skip N2), and clinical (c-) N factor have been cited. We investigated these factors pathological (pIIIA) NSCLC. reviewed 121...
OBJECTIVESAlthough video-assisted thoracoscopic surgery (VATS) is widely used for the resection of a mediastinal mass, it converted to an open in some patients with mature teratoma because dense adhesions. We reviewed cases removed by VATS and investigated indications that procedure this tumour.
OBJECTIVESThe existence of clustered isolated tumour cells (ITCs) in the pulmonary vein (PV) lungs patients with lung cancer has been reported to be a prognostic factor. However, clinical–pathological characteristics related their presence PV remain unclear.