A5051742779- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Venomous Animal Envenomation and Studies
- Gastric Cancer Management and Outcomes
- Immune Response and Inflammation
- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Immune cells in cancer
- Tracheal and airway disorders
- Pleural and Pulmonary Diseases
- Myasthenia Gravis and Thymoma
- Abdominal Surgery and Complications
- Erythrocyte Function and Pathophysiology
- Cellular transport and secretion
- Pancreatic and Hepatic Oncology Research
- Airway Management and Intubation Techniques
- Gastrointestinal Tumor Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Liver Disease and Transplantation
- Marine Invertebrate Physiology and Ecology
- Lung Cancer Research Studies
- Esophageal and GI Pathology
- Appendicitis Diagnosis and Management
- Trauma Management and Diagnosis
Kawasaki Medical School
2024-2025
Sakai Municipal Hospital
2019-2024
Nagahama Institute of Bio-Science and Technology
2024
Jikei University School of Medicine
2024
Tokyo University of Pharmacy and Life Sciences
2018-2023
EA Pharma (Japan)
2019-2022
Osaka University
2001-2020
Hokkaido University
2020
International University of Health and Welfare
2019
Kobe University
2013-2016
Interleukin-8 (IL-8) is a newly described leukocyte chemotactic and activating cytokine that belongs to the novel family of inflammatory cytokines whose genes locate on human chromosome 4, q12-21 region. The production IL-8 usually not constitutive can be induced rapidly abundantly in different cell types by variety stimuli such as lipopolysaccharide, interleukin-1, tumor necrosis factor-alpha well promotor phorbol myristate acetate. We report here addition these gene also protein X...
Inflammatory stimuli cause a state of emergency myelopoiesis leading to neutrophil-like monocyte expansion. However, their function, the committed precursors, or growth factors remain elusive. In this study we find that Ym1+Ly6Chi monocytes, an immunoregulatory entity arise from progenitors neutrophil 1 (proNeu1). Granulocyte-colony stimulating factor (G-CSF) favors production monocytes through previously unknown CD81+CX3CR1lo precursors. GFI1 promotes differentiation proNeu2 proNeu1 at cost...
Ly6Chi monocytes migrate to injured sites and induce inflammation in the acute phase of tissue injury. However, once causes injury are eliminated, monocyte-derived macrophages contribute resolution repair. It remains unclear whether emergence these immunoregulatory is attributed phenotypic conversion inflammatory situ or recruitment bone marrow-derived regulatory cells de novo. Here, we identified a subpopulation that Ym1+Ly6Chi greatly expanded marrow during recovery systemic infiltrating...
Salvage high-dose-rate brachytherapy (HDR-BT) is a potential treatment for localized recurrence of prostate cancer following definitive radiation therapy. This study aimed to evaluate the long-term safety and efficacy HDR-BT alone, without androgen deprivation therapy (ADT), in this patient population. We conducted retrospective analysis patients with who developed pathologically confirmed local after were treated salvage alone at Kawasaki Medical School Hospital between 2007 2021. The...
Abstract Macrophages manifest distinct phenotype according to the organs in which they reside. In addition, flexibly switch their character adaptation changing environment. However, molecular basis that explains conversion of macrophage has so far been unexplored. We find CD169+ macrophages change by regulating level a transcription factor Maf both vitro and vivo C57BL/6J mice. When were exposed bacterial components, expressed an array acute inflammatory response genes Maf-dependent manner...
Systemic and local inflammation associated with therapeutic intervention of primary tumor occasionally promotes metastatic recurrence in mouse human. However, it remains unclear what types immune cells are involved this process. Here, we found that the tissue-repair-promoting Ym1 + Ly6C hi monocyte subset expanded as a result systemic induced by intravenous injection lipopolysaccharide or resection promoted lung metastasis originating from circulating (CTCs). Deletion suppressed...
In this study, we demonstrate the one-step production of cadaverine (1,5-diaminopentane) from cellobiose using an Escherichia coli strain displaying β-glucosidase (BGL) on its cell surface. L-lysine decarboxylase (CadA) derived E. and BGL Thermobifida fusca YX (Tfu0937) fused to anchor protein Blc were co-expressed as a host. The expression CadA was confirmed by Western blotting activity surface evaluated pNPG substrate. Growth sole carbon source also achieved. OD600 value co-expressing 8.0...
Aims AJM300 is an oral antagonist of α4‐integrin that reduces inflammation by blocking leucocyte trafficking. This study aimed to investigate safety, tolerability, pharmacokinetics and pharmacodynamics in healthy male subjects. Methods A total 23 subjects were randomised receive 240 mg ( n = 6), 480 5), 960 6) or the corresponding placebo 2 per group). The drugs taken orally 3 times daily after each meal on first day followed a 4‐day washout period. Thereafter, multiple‐dose administration...
Abstract The tyrosine kinase c-Src is upregulated in various human cancers, although the precise regulatory mechanism underlying this upregulation unclear. We previously reported that a transmembrane adaptor Csk-binding protein (Cbp; PAG1) plays an important role controlling cell transformation induced by activation of c-Src. To elucidate vivo Cbp, we examined function Cbp lung cancer lines and tissues. In study, found was markedly downregulated non–small (NSCLC) cells. ectopic expression...
As the number of long-term survivors pancreatic cancer is expected to increase thanks recent advances in multidisciplinary treatment and earlier diagnoses cancer, we are likely encounter more cases postoperative pulmonary nodules. We analyzed clinical course prognosis resection metastases from clarify prognostic implication metastasectomy for cancer.We retrospectively 35 patients who underwent lung after surgery. Short- outcomes factors associated with were analyzed.The observation period...
Septic shock remains a serious disorder associated with high mortality. Accumulating evidence indicates that TNF is major and essential mediator of endotoxin shock. We report here administration an antibody against CD18 dramatically reduced endotoxin-induced in rabbits as revealed by prevention severe hypotension, metabolic acidosis pathological change suggestive disseminated intravascular coagulation concomitant inhibition elevation plasma activity. The anti-CD18 also inhibited the...
Acute lethality was induced in rabbits by the sequential injection of Propionibacterium acnes and lipopolysaccharide (LPS). P. infiltration inflammatory cells into liver lobules during early phase, LPS late phase caused death association with pathological changes mimicking hepatocellular necrosis or degeneration around infiltrated mononuclear fibrin deposition liver, lung, kidney, suggestive a systemic Schwartzman-like reaction. These were accompanied elevation plasma tumor factor (TNF)...
It has been reported that the chemically synthesized 3'-sulfo-Le(a) and 3'-sulfo-Le(x) epitopes have a high potential as ligand for selectins. To elucidate physiological functions of 3'-sulfated Lewis epitopes, remodeling system was developed using combination betaGal-3-O-sulfotransferase GP3ST, hitherto known alpha1,3/1,4-fucosyltransferases (FucT-III, IV, V, VI, VII, IX) arylsulfatase A. The pyridylaminated (PA) lacto-N-tetraose (Galbeta1-3GlcNAcbeta1-3Galbeta1-4Glc) first converted to...
Adenoid cystic carcinoma (ACC), which is a subtype of the nonpapillary adenocarcinoma thymus, extremely rare. We report patient with thymic ACC-like features presented multiple bone and pulmonary metastases that underwent surgery. The present case firstly demonstrated could have metastatic potential.
Impaired nutrition is an important predictor of perioperative complications in lung cancer patients, and preoperative chemoradiotherapy increases the risk such complications. The goal this study was to assess effect immune-enhancing diet on nutritional status patients undergoing resection after chemoradiotherapy. We compared 15 with without who had Body mass index lymphocyte counts were lower Although there no difference rate postoperative morbidity between groups, more likely have severe...
Recently, the utilization of surgical stabilization rib fractures (SSRF) with video-assisted thoracoscopic surgery (VATS) has been increasing owing to its effectiveness. The present report describes case a patient who underwent SSRF VATS and subsequently developed splenic rupture that was speculated be related intrathoracic manipulation during surgery.
Abstract Purpose Until March 2018, patients with high-risk localized prostate cancer had been administered high-dose-rate brachytherapy (HDR-BT) combined external beam radiotherapy (EBRT) without additional hormone therapy (HT) at our institution. In this study, we aimed to evaluate long-term outcomes of treatment. Materials and methods Patients who received HDR-BT EBRT between April 1997 2021 were followed up for least 6 months included in the study. High-risk groups classified into five...