A5052247299- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Myasthenia Gravis and Thymoma
- Pleural and Pulmonary Diseases
- Cardiac tumors and thrombi
- Radiomics and Machine Learning in Medical Imaging
- Tracheal and airway disorders
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Meningioma and schwannoma management
- Salivary Gland Tumors Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
- Esophageal and GI Pathology
- Management of metastatic bone disease
- Cardiac, Anesthesia and Surgical Outcomes
- Renal cell carcinoma treatment
- Medical Imaging Techniques and Applications
Osaka International Cancer Institute
2022-2025
Osaka University
2014-2024
Lund University
2020-2024
Nippon Kayaku (Japan)
2023
Bristol-Myers Squibb (Germany)
2023
Kyowa Kirin (Japan)
2023
Bayer (United States)
2023
Eisai (United States)
2023
Janssen (Belgium)
2023
Chugai Pharma (United States)
2023
IntroductionTo investigate the clinical performance of AMOY 9-in-1 kit (AMOY) in comparison with a next-generation sequencing (NGS) panel lung cancer patients.MethodsLung patients enrolled LC-SCRUM-Asia program at single institution were analyzed for success rate analysis, detection targetable driver mutations, turn around time (TAT) from specimen submission to result reporting, and concordance results NGS panel.ResultsOf 406 included 81.3% had adenocarcinoma. The rates 98.5% 87.8%,...
Despite the report of new treatment options, surgery remains best for pulmonary metastases from renal cell carcinoma (RCC). Repeat resection is also an effective means recurrent metastases. The aim present study was to define prognostic factors survival after metastasectomy RCC based on a 25-year single-centre experience.Between 1973 and 2008, 59 thoracotomies 48 patients (38 men, 10 women) were performed in our hospital. resections eight patients. clinicopathological surgical data these...
Postoperative recurrences of uncertain malignant potential [(smooth muscle tumors (STUMPs)] have been reported, with lung as the most common site. Herein, we describe pulmonary metastases a uterine STUMP presenting bullae in female patient. Computed tomography revealed two left several both lungs, and patient was referred to our department for metastasectomy. Despite mild right pneumothorax on admission, metastasectomy bullectomy were safely performed, an uneventful postoperative course....
Alterations to the tumor stromal microenvironment induced by chemotherapy could influence behavior of cancer cells. In microenvironment, cancer-associated fibroblasts (CAFs) play an important role. Because receptor tyrosine kinase Axl and its ligand Gas6 be involved in promoting non-small cell lung (NSCLC), we investigated role secreted CAFs during NSCLC. a murine model, found that expression was upregulated following cisplatin treatment. might influenced intratumoral hypoperfusion...
F18-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT), which allows differentiation between malignant and benign lesions based on difference in tissue glucose metabolism, has become increasingly important lung cancer diagnosis. This study examined the clinical value of FDG-PET/CT a large number patients with non-small cell (NSCLC) after potentially curative surgery.Four hundred ninety 241 (143 males 98 females; age range 38-87 years; mean 68.0 years) May 2006...
There is little information on pulmonary metastasectomy of urinary tract transitional cell carcinoma (TCC). In this study, we examined the long-term outcome and factors associated with survival after TCC based a 20-year single center experience. Between 1984 2005, 18 patients (12 men, six women) underwent in our hospital. The clinicopathological surgical data these obtained from medical records were analyzed retrospective study. time interval between lung resection death, or latest follow-up...
Epithelial–mesenchymal transition ( EMT ) plays an important role in the progression of lung carcinoma. Podocalyxin PODXL ), which belongs to CD 34 family and regulates cell morphology, has been linked cancer, overexpression is associated with poor prognosis several different classes cancers. The aim this study was clarify determine prognostic value tumors from cancer patients. marker expression, migration invasion abilities engineered A549 ‐knockdown KD or ‐overexpression OE adenocarcinoma...
Abstract Background The significance of epithelial‐mesenchymal transition (EMT) and immune checkpoint proteins in thymic carcinoma remains unknown. We examined the clinical EMT, tumor‐infiltrating lymphocytes expressing protein, programmed cell death 1 (PD‐1 + TILs), expression PD‐1 ligand (PD‐L1) (TC). also investigated relationships between these EMT status impact induction chemotherapy on patients with tumors that express proteins. Methods relationship TILs/PD‐L1 clinicopathological...
Indications for current immune checkpoint inhibitors are expanding and now include thymic epithelial tumors (TETs). Although clinical trials on TETs ongoing, a rationale has not yet been established immunotherapy TETs. Therefore, we herein performed phenotypic functional analyses of T cells in surgically resected TET tissues with focus the anti-tumor properties to as step towards establishing We examined T-cell profiles tissues, particularly CD4 CD8 single-positive cells, using flow...
Information on prognostic factors after repeat pulmonary metastasectomy (PM) is limited, and outcomes a third PM are not well documented.
Hepatocellular carcinoma (HCC) rarely originates in extrahepatic liver tissue. Laparoscopic resection is widely used to treat HCC. This report presents a case of patient with ectopic HCC arising the left triangular ligament that was successfully treated by laparoscopic resection. A 59-year-old female presented an elevated serum alpha-fetoprotein (AFP) level (2,508 ng/ml). Dynamic computed tomography demonstrated tumor measuring 20 mm diameter below diaphragm just adjacent spleen. The showed...
The results of preoperative chemotherapy or chemoradiotherapy followed by surgery for locally advanced thymoma were analysed.Between 1997 and 2016, 29 patients with a underwent surgery. These cases retrospectively reviewed.The study population included 9 men 20 women, mean age 48.8 years (range 31-68 years). Masaoka stage was III in 12, IVa 13 IVb 4 patients, whereas histological type B3 11, B2 others 5 patients. tumour size 8.0 ± 2.5 cm (3.4-15.0 cm). site infiltration shown radiological...
A new pathological classification for pre- and minimally invasive adenocarcinoma has been established, with distinction prior to surgery crucial because of the extremely good prognosis. Of 412 patients who underwent lung cancer from 2008 2011, 110 classified as c-stage I had each following four parameters assessed predictive power or relapse-free survival (RFS): (i) whole tumour size (WS) shown by computed tomography (CT) , (ii) solid (SS) component in CT findings, (iii) maximum standard...
A common cause of complications after a pulmonary resection procedure is prolonged air leakage. Recently introduced digital drainage systems provide accurate recording leak data for later review. We investigated the clinical usefulness continuous stream recorded by such device.We analyzed obtained from 299 patients with malignancy who underwent lung cancer use chest system. Postoperative patterns were divided into 4 groups and their correlation leakage was evaluated.The incidence 10%...