A5041796082- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Neuroendocrine Tumor Research Advances
- Glycosylation and Glycoproteins Research
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Cancer-related molecular mechanisms research
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- HER2/EGFR in Cancer Research
- Tracheal and airway disorders
- Immunotherapy and Immune Responses
- Cancer therapeutics and mechanisms
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- Drug Transport and Resistance Mechanisms
Osaka University
2016-2025
Osaka Health Science University
2022
Takeda (United States)
2022
Weatherford College
2022
Eastern Cooperative Oncology Group
2017
Creative Commons
2017
Christie's
2017
University of Pennsylvania
2009-2012
Japan Science and Technology Agency
2012
Osaka University Hospital
2012
BACKGROUND. The PD-1–blocking antibody nivolumab persists in patients several weeks after the last infusion. However, no study has systematically evaluated maximum duration that on T cells or association between this and residual therapeutic efficacy potential adverse events.
Abstract The aim of this study was to investigate the clinical impact sarcopenia on efficacy programmed death (PD)-1 inhibitors. We retrospectively reviewed medical records all patients treated with nivolumab or pembrolizumab between January 2016 and September 2018 for previously advanced non–small cell lung cancer (NSCLC). cross-sectional area psoas muscle at level third lumbar vertebra baseline computed tomography assessed calculate index (PMI). Sarcopenia defined based PMI cut-off values...
Genotyping of EGFR (epidermal growth factor receptor) mutations is indispensable for making therapeutic decisions regarding whether to use tyrosine kinase inhibitors (TKIs) lung cancer. Because some cases might pose challenges biopsy, noninvasive genotyping in circulating tumor DNA (ctDNA) would be beneficial cancer treatment.We developed a detection system ctDNA by deep sequencing plasma DNA. Mutations were searched >100 000 reads obtained from each exon region. Parameters corresponding the...
PD-1 blockade exerts antitumor effects by reinvigorating tumor antigen–specific CD8+ T cells. Whereas neoantigens arising from gene alterations in cancer cells comprise critical antigens immunity, a subset of non–small cell lung cancers (NSCLCs) harboring substantial mutation burden (TMB) lack the microenvironment (TME), which results resistance to therapy. To overcome this resistance, clarifying mechanism(s) impairing immunity highly mutated NSCLCs is an urgent issue. Here, we showed that...
Abstract Introduction Nivolumab plus ipilimumab with chemotherapy (NICT) and pembrolizumab (PCT) are commonly used in patients advanced non-small cell lung cancer (NSCLC). Compared immune checkpoint inhibitor (ICI) monotherapy, ICI combination therapy can increase immune-related toxicity instead of prolonging survival. This study aimed to compare the efficacy safety NICT PCT decide on favorable treatment. Methods We conducted a multi-center retrospective cohort who underwent or between...
Positron emission tomography (PET) with [(18)F]fluorodeoxyglucose (FDG) is increasingly used in early assessment of tumor response after chemotherapy. We investigated whether a change [(18)F]FDG uptake at 2 days gefitinib treatment predicts outcome patients lung adenocarcinoma.Twenty were enrolled. [(18)F]FDG-PET/computed tomographic (CT) scan was carried out before and treatment. Maximum standardized values (SUV) measured, post-gefitinib percentage changes SUV calculated. Early metabolic...
Although multiple studies have identified skipping breakfast as a risk factor for weight gain, there is limited evidence on the clinical impact of lunch and dinner gain. This retrospective cohort study including 17,573 male 8860 female university students at national in Japan, assessed association frequency breakfast, lunch, with incidence gain (≥10%) overweight/obesity (body mass index ≥ 25 kg/m2), using annual participant health checkup data. Within observation period 3.0 ± 0.9 years, ≥10%...
Immune checkpoint inhibitors (ICIs) have caused revolutionary changes in cancer treatment, but low response rates remain a challenge. Semaphorin 4A (Sema4A) modulates the immune system through multiple mechanisms mice, although role of human Sema4A tumor microenvironment remains unclear. This study demonstrates that histologically Sema4A-positive non–small cell lung (NSCLC) responded significantly better to anti–programmed death 1 (PD-1) antibody than Sema4A-negative NSCLC. Intriguingly,...
BackgroundNovel biomarkers (BMs) are urgently needed for bronchial asthma (BA) with various phenotypes and endotypes.ObjectiveWe sought to identify novel BMs reflecting tissue pathology from serum extracellular vesicles (EVs).MethodsWe performed data-independent acquisition of EVs 4 healthy controls, noneosinophilic (NEA) patients, eosinophilic (EA) patients BA. We confirmed EA-specific via validation in 61 BA 23 controls. To further validate these findings, we 6 chronic rhinosinusitis...
Abstract Small cell lung cancer (SCLC) is an aggressive malignancy with extremely high mortality due to the appearance of widespread metastases early in its clinical course and rapid acquisition chemoresistance after initial therapy. A theory adhesion–mediated drug resistance thought be a principal mechanism which extracellular matrix proteins provide survival advantage against cytotoxic drug-induced apoptosis. We found that tetraspanin family member CD9 was expressed preferentially SCLC...
Chronic obstructive pulmonary disease is frequently complicated with comorbidities, such as cardiovascular disease, osteoporosis, and body weight loss, but the causal link remains unclear.To investigate role of adiponectin in pathogenesis chronic its potential use therapy.Adiponectin localization dynamics lung were analyzed an elastase-induced emphysema model. Next, adiponectin-knockout mice, extrapulmonary effects, underlying mechanism investigated. Finally, we tested whether exogenous...
Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with COPD-like phenotype progressively developed syndrome resembling human including cataracts, hair loss, atrophy various organs, thymus, muscle, testis, resulting shorter survival than wild-type (WT) mice....
Nontuberculous mycobacterial pulmonary disease (NTM-PD), mainly caused by Mycobacterium avium complex (MAC), and tuberculosis (TB) are emerging health problems worldwide. However, because their clinical features often similar, it remains difficult to differentiate NTM-PD from TB when the diagnosis cannot be made sputum culture. To investigate potential serum biomarkers, we conducted non-targeted proteome analysis on extracellular vesicles (EVs) collected 10 patients with MAC (MAC-PD), 7 TB,...
Abstract Stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. Although evidence exists in support positive role for cancer, its has remained somewhat controversial because insufficient study how genetic deletion may affect carcinogenesis various tissues. In this study, we show using epithelium-specific knockout mice (Stat3Δ/Δ) that blunts rather than supports antitumor immunity carcinogen-induced lung tumorigenesis. Stat3Δ/Δ did...
Tetraspanins have emerged as key players in malignancy and inflammatory diseases, yet little is known about their roles angiogenesis, nothing involvement lymphangiogenesis. We found here that tetraspanins are abundantly expressed human lymphatic endothelial cells (LEC). After intrathoracic tumor implantation, metastasis to lymph nodes was diminished accompanied by decreased angiogenesis lymphangiogenesis tetraspanin CD9-KO mice. Moreover, lymphangiomas induced mice were less pronounced with...
Although responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) are initially positive, 30%-40% of patients with EGFR-mutant tumors do not respond well EGFR-TKIs, and most lung cancer harboring mutations experience relapse resistance. Therefore, it is necessary identify only the mechanisms underlying EGFR-TKI resistance, but also potentially novel therapeutic targets and/or predictive biomarkers for adenocarcinoma. We found that GPI-anchored protein semaphorin 7A (SEMA7A) highly induced by...
Abstract Lung adenocarcinoma is the most common histological type of lung cancer and classified into in situ (AIS), minimally invasive (MIA) (IA). Atypical adenomatous hyperplasia (AAH) lesions are possible precursors to adenocarcinoma. However, mechanism underlying stepwise continuum unclear. In this study, involvement ADP‐ribosylation factor (ARF)‐like (ARL) 4C (ARL4C), a member small GTP‐binding protein family, progression possibility ARL4C as molecular target for therapy were explored....
The methyltransferase-like 3 (METTL3)-/METTL14-containing complex predominantly catalyzes N6-methyladenosine (m6A) modification, which affects mRNA stability. Although the METTL14 R298P mutation is found in multiple cancer types, its biological effects are not completely understood. Here, we show that heterozygous promotes cell proliferation, whereas homozygous reduces proliferation. Methylated RNA immunoprecipitation sequencing analysis indicates m6A modification at canonical motifs....
Idiopathic pulmonary fibrosis (IPF) is a chronic disorder of unknown etiology with few treatment options. Although tetraspanins are involved in various diseases, their roles have not been determined.To investigate the role tetraspanin CD151 fibrosis.CD151 knockout (KO) mice were studied by histological, biochemical, and physiological analyses compared wild-type CD9 KO mice. Further mechanistic performed vitro, vivo, on samples from patients IPF.A microarray study identified an enrichment...