A5053803071- Obesity, Physical Activity, Diet
- Fibroblast Growth Factor Research
- Parathyroid Disorders and Treatments
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Dialysis and Renal Disease Management
- Helicobacter pylori-related gastroenterology studies
- Kruppel-like factors research
- Sleep and related disorders
- Biomarkers in Disease Mechanisms
- Smoking Behavior and Cessation
- Lung Cancer Treatments and Mutations
- Birth, Development, and Health
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Liver Diseases and Immunity
- Connective tissue disorders research
- Blood groups and transfusion
- Lung Cancer Research Studies
- Alcohol Consumption and Health Effects
- Substance Abuse Treatment and Outcomes
- Animal Virus Infections Studies
- Epigenetics and DNA Methylation
- Chronic Obstructive Pulmonary Disease (COPD) Research
Osaka University
2015-2024
Smoking Research Foundation
2024
Osaka Health Science University
2015-2022
Hokkaido Institute of Public Health
2022
Kanazawa Medical Center
2018
Kinki Central Hospital
2017
Shin Koga Hospital
2015
Nayoro City General Hospital
2015
Sapporo Medical University
1969-2011
Azabu University
2011
Background Vocal learning is a central functional constituent of human speech, and recent studies showing that adult male mice emit ultrasonic sound sequences characterized as "songs" have suggested the courtship sounds provide mammalian model vocal learning. Objectives We tested whether mouse songs are learned, by examining relative role rearing environment in cross-fostering experiment. Methods Findings found C57BL/6 BALB/c males clearly different pattern with frequency syllable...
Although multiple studies have identified skipping breakfast as a risk factor for weight gain, there is limited evidence on the clinical impact of lunch and dinner gain. This retrospective cohort study including 17,573 male 8860 female university students at national in Japan, assessed association frequency breakfast, lunch, with incidence gain (≥10%) overweight/obesity (body mass index ≥ 25 kg/m2), using annual participant health checkup data. Within observation period 3.0 ± 0.9 years, ≥10%...
Chronic obstructive pulmonary disease is frequently complicated with comorbidities, such as cardiovascular disease, osteoporosis, and body weight loss, but the causal link remains unclear.To investigate role of adiponectin in pathogenesis chronic its potential use therapy.Adiponectin localization dynamics lung were analyzed an elastase-induced emphysema model. Next, adiponectin-knockout mice, extrapulmonary effects, underlying mechanism investigated. Finally, we tested whether exogenous...
Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with COPD-like phenotype progressively developed syndrome resembling human including cataracts, hair loss, atrophy various organs, thymus, muscle, testis, resulting shorter survival than wild-type (WT) mice....
Tetraspanins have emerged as key players in malignancy and inflammatory diseases, yet little is known about their roles angiogenesis, nothing involvement lymphangiogenesis. We found here that tetraspanins are abundantly expressed human lymphatic endothelial cells (LEC). After intrathoracic tumor implantation, metastasis to lymph nodes was diminished accompanied by decreased angiogenesis lymphangiogenesis tetraspanin CD9-KO mice. Moreover, lymphangiomas induced mice were less pronounced with...
Tetraspanins organize protein complexes in tetraspanin-enriched membrane microdomains that are distinct from lipid rafts. Our previous studies suggested reduction the levels of tetraspanins CD9 and CD81 may be involved progression inflammatory lung diseases, especially COPD. To search for agents increase these tetraspanins, we screened 1,165 drugs clinical use found statins upregulate RAW264.7 macrophages. The lipophilic statins, fluvastatin simvastatin, reversed LPS-induced downregulation...
Abstract While aging is unavoidable, the mechanism still unclear because of its complexity. Smoking causes premature death and considered as an environmental accelerator. In present study, we focused on influence smoking to serum concentration anti-aging protein α-klotho (αKl) β-klotho-associated fibroblast growth factor (FGF)-21 in men. Subjects consisted apparently healthy men over 40 years age who underwent health examination. Physical biochemical parameters, including levels several...
There is an unmet need for novel biomarkers in the diagnosis of multifactorial COPD. We applied next-generation proteomics to serum extracellular vesicles (EVs) discover COPD biomarkers. EVs from 10 patients with and six healthy controls were analysed by tandem mass tag-based non-targeted proteomics, those elastase-treated mouse models emphysema also proteomics. For validation, 23 20 validated targeted Using we identified 406 proteins, 34 which significantly upregulated Of note, EV protein...
Smoking and metabolic syndrome (MetS) are major public health problems in modern society important risk factors of cardiovascular disease (CVD). The association smoking, MetS, CVD is widely reported, but reports targeted to women few. In the present study, we evaluated factors, including visceral fat area (VFA), for development subclinical atherosclerosis female smokers especially.Subjects consisted 162 apparent healthy male smokers, 315 age-matched never-smokers who underwent a examination...
Abstract Heart failure is a major cause of death with an increasing population elderly individuals. Several studies have demonstrated the involvement soluble alpha-Klotho (sαKl) in various diseases. However, correlation between sαKl and heart remains to be understood. The aim this study investigate levels role patients failure. Twenty-eight consecutive acute (19 male, 9 female), admitted Osaka University Hospital from 2010 2018, were enrolled study. Mean NYHA score, left ventricular ejection...
Men and women react differently to some disease states, are reported be more sensitive than men the toxic effects of smoking. We examined serum concentration Klotho-related molecules, α-Klotho (αKl) fibroblast growth factor (FGF)-21, influence smoking on these molecules in both sexes.Subjects included 90 140 good health who underwent a examination.Among male subjects, concentrations FGF-21, soluble sαKl, inflammation-related cytokine interleukin (IL)-6 were significantly higher smokers...
Abstract Fibroblast growth factor (FGF) 21 has various functions, including glucose and lipid metabolism. This cross-sectional study aimed to investigate specific conditions that might influence the functions of FGF21. 398 men who underwent a health examination were enrolled in this study. Physical biochemical parameters information on several lifestyle behaviors obtained from all subjects. FGF21 levels correlated with age, body mass index (BMI), waist circumference (WC), systolic blood...
Singing in an indoor space may increase the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We conducted a case-control study karaoke-related disease 2019 (COVID-19) outbreaks to reveal factors for SARS-CoV-2 infection among individuals who participate karaoke.Cases were defined as people enjoyed karaoke at bar and tested positive by reverse-transcription polymerase chain reaction between 16 May 3 July 2020. Controls same during period cases negative. Odds...
We conducted a cross-sectional survey among SARS-CoV-2-positive persons and negative controls in Sapporo, Japan, to clarify symptoms of long COVID. collected responses from 8,018 participants, 3,694 case-patients 3,672 controls. calculated symptom prevalence for at 2-3, 4-6, 7-9, 10-12, 13-18 months after illness onset. used logistic regression, adjusted age sex, estimate the odds ratio (OR) each control reference. by stratifying disease severity, age, sex. At 4-18 onset, ORs anosmia,...
A 61-year-old male who originally visited a different hospital, underwent health checkup in which multiple lung nodules were detected. Multiple well-defined small observed both lungs, with lesions reaching the arteries. Metastatic cancer, unknown origin, was suspected. computed tomography-guided percutaneous biopsy performed; however, pathological diagnosis could not be established. Then patient referred to our hospital for surgical biopsy. Macroscopically, nodule dark-red color and solid...
Frequency of alcohol drinking is a potential predictor binge alcohol, serious social problem for university students. Although previous studies have identified skipping breakfast as various health-compromising behaviors and cardiometabolic diseases, few assessed the association between incidence frequent drinking. This retrospective cohort study included 17,380 male 8799 female students aged 18–22 years admitted to Osaka universities 2004 2015. The frequency (eating every day, occasionally,...
To identify the lifestyle factors responsible for increases in serum gamma-glutamyltransferase (GGT), 1014 hepatobiliary dysfunction-free (no medication and no past history of liver disease, < or = 39 U/L aspartate and/or alanine aminotransferase, 59 GGT) Japanese male office workers aged 35-55 years were examined annually over five successive (average period 4.5 years, SD 1.11 years). From Cox proportional hazards model without GGT at entry, significant correlates with incidence increased...
In this study, the full-length genome sequence of prototype sapovirus, namely Sapporo virus (SV82), was identified. RNA extracted from a fecal sample, amplified by RT-PCR and PCR products sequenced directly analyzed. Sequence analysis showed that consists 7433 nucleotides has three open reading frames. The strain shows 91.7% nucleotide identity to Manchester virus. Phylogenic also revealed closeness other sapovirus/genogroup I strains. Basic information on evolutionary history sapovirus is...