A5033484471- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Salivary Gland Tumors Diagnosis and Treatment
- CAR-T cell therapy research
- Myasthenia Gravis and Thymoma
- Axon Guidance and Neuronal Signaling
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sarcoidosis and Beryllium Toxicity Research
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Bladder and Urothelial Cancer Treatments
- Phagocytosis and Immune Regulation
- Sinusitis and nasal conditions
- Ferroptosis and cancer prognosis
- T-cell and Retrovirus Studies
- Pulmonary Hypertension Research and Treatments
- Vector-Borne Animal Diseases
- Radiomics and Machine Learning in Medical Imaging
- Advanced Proteomics Techniques and Applications
- HER2/EGFR in Cancer Research
Osaka University
2018-2024
Osaka Police Hospital
2024
Takeda (United States)
2022
Weatherford College
2022
Osaka International University
2018-2021
Japan Agency for Medical Research and Development
2018
Itami City Hospital
2013
BACKGROUND. The PD-1–blocking antibody nivolumab persists in patients several weeks after the last infusion. However, no study has systematically evaluated maximum duration that on T cells or association between this and residual therapeutic efficacy potential adverse events.
Immune checkpoint inhibitors (ICIs) have caused revolutionary changes in cancer treatment, but low response rates remain a challenge. Semaphorin 4A (Sema4A) modulates the immune system through multiple mechanisms mice, although role of human Sema4A tumor microenvironment remains unclear. This study demonstrates that histologically Sema4A-positive non–small cell lung (NSCLC) responded significantly better to anti–programmed death 1 (PD-1) antibody than Sema4A-negative NSCLC. Intriguingly,...
Abstract Introduction Nivolumab plus ipilimumab with chemotherapy (NICT) and pembrolizumab (PCT) are commonly used in patients advanced non-small cell lung cancer (NSCLC). Compared immune checkpoint inhibitor (ICI) monotherapy, ICI combination therapy can increase immune-related toxicity instead of prolonging survival. This study aimed to compare the efficacy safety NICT PCT decide on favorable treatment. Methods We conducted a multi-center retrospective cohort who underwent or between...
BackgroundNovel biomarkers (BMs) are urgently needed for bronchial asthma (BA) with various phenotypes and endotypes.ObjectiveWe sought to identify novel BMs reflecting tissue pathology from serum extracellular vesicles (EVs).MethodsWe performed data-independent acquisition of EVs 4 healthy controls, noneosinophilic (NEA) patients, eosinophilic (EA) patients BA. We confirmed EA-specific via validation in 61 BA 23 controls. To further validate these findings, we 6 chronic rhinosinusitis...
Progressive pulmonary fibrosis (PPF), defined as the worsening of various interstitial lung diseases (ILDs), currently lacks useful biomarkers. To identify novel biomarkers for early detection patients at risk PPF, we performed a proteomic analysis serum extracellular vesicles (EVs). Notably, identified candidate were enriched lung-derived proteins participating in fibrosis-related pathways. Among them, surfactant-associated protein B (SFTPB) EVs could predict ILD progression better than...
Although responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) are initially positive, 30%-40% of patients with EGFR-mutant tumors do not respond well EGFR-TKIs, and most lung cancer harboring mutations experience relapse resistance. Therefore, it is necessary identify only the mechanisms underlying EGFR-TKI resistance, but also potentially novel therapeutic targets and/or predictive biomarkers for adenocarcinoma. We found that GPI-anchored protein semaphorin 7A (SEMA7A) highly induced by...
There is an unmet need for novel biomarkers in the diagnosis of multifactorial COPD. We applied next-generation proteomics to serum extracellular vesicles (EVs) discover COPD biomarkers. EVs from 10 patients with and six healthy controls were analysed by tandem mass tag-based non-targeted proteomics, those elastase-treated mouse models emphysema also proteomics. For validation, 23 20 validated targeted Using we identified 406 proteins, 34 which significantly upregulated Of note, EV protein...
Abstract Coronavirus disease 2019 (COVID‐19) can cause severe lymphopenia and respiratory failure requiring prolonged invasive mechanical ventilation (MV). COVID‐19 patients with or are at risk of developing secondary infections. Here, we present the needle autopsy findings a critically ill patient who required reintubation MV, eventually died cytomegalovirus (CMV) pneumonia. This case highlights potential long‐term steroid use need for routine monitoring CMV infection in COVID‐19.
Abstract Cancer immunotherapy has shown great promise as a new standard therapeutic strategy against cancer. However, the response rate and survival benefit remain unsatisfactory because most current approaches, such use of immune checkpoint inhibitors, depend on spontaneous antitumor responses. One possibility for improving efficacy is to promote immunity using adjuvants or specific cytokines actively. IL-33 been candidate cytokine therapies, but it remains unclear how in which situations...
This is the first report of COVID-19 in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier. HTLV-1 infection can cause immune dysfunction even asymptomatic carriers. case highlights need for guidance on management COVID-19-HTLV-1 coinfection, specifically appropriate use corticosteroid treatment while considering secondary infection.
Abstract Sarcoidosis is a complex, polygenic, inflammatory granulomatous multi-organ disease of unknown cause. The inflammation in sarcoidosis driven by the interplay between T cells and macrophages. Extracellular vesicles (EVs) play important roles intercellular communication. We subjected serum EVs, isolated size exclusion chromatography, from seven patients with five control subjects to non-targeted proteomics analysis. Non-targeted, label-free analysis detected 2292 proteins EVs; 42 were...
Abstract Anti-programmed cell death-1 (PD-1) therapy exerts beneficial effects in a limited population of cancer patients. Therefore, more accurate diagnostics to predict the efficacy anti-PD-1 are desired. The present study investigated whether peripheral T cytotoxicity predicts for advanced non-small lung (NSCLC) Advanced NSCLC patients treated with monotherapy (nivolumab or pembrolizumab) were consecutively enrolled study. Peripheral blood samples subjected an analysis and flow cytometry...
Combined small cell lung cancer (c‐SCLC) is a relatively rare subtype of SCLC and defined by the combination any elements non‐small carcinoma (NSCLC). Standard chemotherapy for patients with c‐SCLC has not yet been established. Gene mutations such as epidermal growth factor receptor (EGFR) may be detected in c‐SCLC. However, little known about anaplastic lymphoma kinase (ALK) rearrangement patients. Here, we report young female patient who was successfully treated alectinib ALK‐positive...
Pure red cell aplasia (PRCA), Good's syndrome (GS), and thymoma-associated multiorgan autoimmunity (TAMA) are associated with thymoma. Herein, we describe the case of a 56-year-old woman PRCA, GS, TAMA simultaneously. She was treated cyclosporine, immunoglobulin supplementation, prednisolone; however, she died uncontrolled sepsis due to extreme immunosuppression. The combination these three diseases is likely lead fatal infections, avoid such it may be necessary reduce or discontinue...
A 58-year-old man underwent upper lobectomy for primary pleomorphic carcinoma of the lung. Nine months later, was recurred with marked peripheral leukocytosis and an elevated C-reactive protein. Chest abdominal computed tomography (CT) revealed enlarged mediastinal lymph nodes a bulky tumor in small intestine. An enterectomy performed intestinal removed. Immunostaining cells positive G-CSF TNF-α as well increased level serum TNF-α. We describe rare case producing lung metastasis to
Abstract Rationale: Thymic carcinoma (TC) is a malignant mediastinal tumor, and there are no established treatments for pre-treated patients with advanced TC. Recently, lenvatinib was approved such in Japan, ahead of other countries. Higher dose may be more efficacious than conventional treatments, although many experience grade 3 hypertension. Therefore, reduction remains controversial terms efficacy tolerability. Patient concerns: Case 1 involves 72-year-old woman who underwent complete...
Pulmonary fibrosis and emphysema result in relatively maintained ventilation reduced diffusing capacity. This pulmonary functional impairment complicates the evaluation of function patients with combined (CPFE). Therefore, a single easy-to-use index to evaluate CPFE warrants further studies. Respiratory impedance can easily be provided by oscillometry might candidate CPFE. As preliminary study assess utility respiratory impedance, we investigated associations physiological indices, including...
Abstract Sarcoidosis is an inflammatory granulomatous multi-organ disease of unknown cause. The inflammation in sarcoidosis driven by the interplay between T cells and macrophages. Extracellular vesicles (EVs) play important roles intercellular communication. Isolated serum EVs from seven patients with five control subjects were subjected to non-targeted proteomics analysis. Then 2,292 proteins detected; 42 upregulated relative subjects, 324 downregulated. protein signature reflected...