A5030894893- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Eosinophilic Disorders and Syndromes
- Cancer Genomics and Diagnostics
- Palliative Care and End-of-Life Issues
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Monoclonal and Polyclonal Antibodies Research
- Drug-Induced Adverse Reactions
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fungal Infections and Studies
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Bacterial Identification and Susceptibility Testing
- Autoimmune Bullous Skin Diseases
- Respiratory Support and Mechanisms
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Axon Guidance and Neuronal Signaling
- Nail Diseases and Treatments
- Frailty in Older Adults
- Rheumatoid Arthritis Research and Therapies
Suita Municipal Hospital
2025
Fukujuji Hospital
2022-2023
Osaka Hospital
2017-2021
Osaka University
2013-2018
Osaka Prefectural Medical Center
2012
Abstract Chronic obstructive pulmonary disease (COPD) has been recently characterized as a of accelerated lung aging, but the mechanism remains unclear. Tetraspanins have emerged key players in malignancy and inflammatory diseases. Here, we found that CD9/CD81 double knockout (DKO) mice with COPD-like phenotype progressively developed syndrome resembling human including cataracts, hair loss, atrophy various organs, thymus, muscle, testis, resulting shorter survival than wild-type (WT) mice....
Although responses to EGFR tyrosine kinase inhibitors (EGFR-TKIs) are initially positive, 30%-40% of patients with EGFR-mutant tumors do not respond well EGFR-TKIs, and most lung cancer harboring mutations experience relapse resistance. Therefore, it is necessary identify only the mechanisms underlying EGFR-TKI resistance, but also potentially novel therapeutic targets and/or predictive biomarkers for adenocarcinoma. We found that GPI-anchored protein semaphorin 7A (SEMA7A) highly induced by...
<title>Abstract</title> Background Hypereosinophilic syndrome is a group of disorders characterized by organ dysfunction caused hypereosinophilia, which frequently leads to thromboembolic complications with potentially fatal outcomes. Interleukin-5, key cytokine that promotes the differentiation and activation eosinophils, has been identified as therapeutic target. Anti-interleukin-5 antibody therapy demonstrated efficacy in reducing eosinophil counts enabling steroid dose tapering patients...
Abstract Small-cell lung cancer (SCLC) easily recurs with a multidrug resistant phenotype. However, standard therapeutic strategies for relapsed SCLC remain unestablished. We found that human epidermal growth factor receptor 2 (HER2) is not only expressed in pretreated specimens, but also upregulated when HER2-positive cells acquire chemoresistance. Trastuzumab induced differential levels of antibody-dependent cell-mediated cytotoxicity (ADCC) to cells. Furthermore, as mechanism the ADCC, we...
AbstractSmall cell lung cancer with interstitial disease (ILD- SCLC)is difficult to treat because of the risk fatal pneu- monitis. Our study aims evaluate validity topotecan (TOP) as chemotherapy for patients re- lapsed ILD-SCLC. Overall survival was compared between TOP and other drugs second-line treatments ILD- SCLC patients. Forty-seven began treatment administered in 48.5% relapsed cases. The response rate therapy 16.7%. Hematologic toxicities were grade 4 anemia, 3 neutropenia...
A 73-year-old man was admitted in respiratory failure that had subacutely progressed after five weeks of dapsone treatment for a skin rash. He also presented with fever, systemic erythroderma and liver dysfunction. Chest computed tomography showed diffuse reticular shadows ground-glass opacity bilateral mediastinal lymphadenopathy. Lymphocytes, but not eosinophils, were increased the bronchoalveolar lavage fluid. Moreover, reactivation human herpes virus-6 confirmed on paired serum test....
An 82-year-old man with miliary tuberculosis was admitted to our hospital. Approximately six weeks after starting anti-tuberculosis treatment, he complained of pain in the fingers, wrists, and ankles. A histopathological examination synovial biopsy revealed nonspecific chronic inflammation no granulomas. Culture specimen yielded acid-fast bacilli. Poncet's disease diagnosed based on clinical presentation, findings suggestive other diseases. His joint rapidly improved steroid therapy....
Endobronchial polypoid lesions can be observed after removal of a foreign body and usually regress without treatment. Bronchial obstruction with cause atelectasis in nonelderly adults history an episode aspiration.
A 78-year-old man developed disseminated cryptococcosis with central nervous system involvement as encapsulated yeast cells were detected in transbronchial biopsy and skin specimens, cer...
Abstract Small-cell lung cancer (SCLC) accounts for approximately 15% of primary and has the poorest outcome all its histological types. One major reasons extreme aggressiveness SCLC is that it recurs shortly after initial therapy with multidrug resistance (MDR) phenotype. However, standard therapeutic strategy relapsed-SCLC not been established yet. As one targetable receptor tyrosine kinases, human epidermal growth factor 2 (HER2) was reported to be a negative prognostic in...