A5027808322- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- Extracellular vesicles in disease
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Neuroendocrine Tumor Research Advances
- Cancer Treatment and Pharmacology
- Brain Metastases and Treatment
- Mycobacterium research and diagnosis
- Chronic Lymphocytic Leukemia Research
- Axon Guidance and Neuronal Signaling
- Sarcoidosis and Beryllium Toxicity Research
- Neuroblastoma Research and Treatments
- Angiogenesis and VEGF in Cancer
- Tracheal and airway disorders
- RNA modifications and cancer
- Medical Imaging and Pathology Studies
Osaka University
2004-2025
Osaka International University
2020-2025
Osaka University Hospital
2025
Kumamoto University
2019-2024
Weatherford College
2022
Takeda (United States)
2022
National Kinki Chuo Hospital for Chest Disease
2017
Christie's
2017
Eastern Cooperative Oncology Group
2017
Creative Commons
2017
BACKGROUND. The PD-1–blocking antibody nivolumab persists in patients several weeks after the last infusion. However, no study has systematically evaluated maximum duration that on T cells or association between this and residual therapeutic efficacy potential adverse events.
<h3>Background</h3> Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function. Levels arginine are regulated by enzymes arginase 1,2 nitric oxide synthase (NOS). However, role activity lung tumor maintenance has not been investigated clinically relevant orthotopic models. <h3>Methods</h3> RNA sequencing (RNA-seq) sorted cell populations...
Small cell lung cancer (SCLC) is a pulmonary neuroendocrine with very poor prognosis and limited effective therapeutic options. Most patients are diagnosed at advanced stages, the exact reason for aggressive metastatic phenotype of SCLC completely unknown. Despite high tumor mutational burden, responses to immune checkpoint blockade minimal in SCLC. This may reflect defects surveillance. Here we illustrate that evading natural killer (NK) surveillance contributes aggressiveness metastasis,...
Immune checkpoint inhibitors (ICIs) have caused revolutionary changes in cancer treatment, but low response rates remain a challenge. Semaphorin 4A (Sema4A) modulates the immune system through multiple mechanisms mice, although role of human Sema4A tumor microenvironment remains unclear. This study demonstrates that histologically Sema4A-positive non–small cell lung (NSCLC) responded significantly better to anti–programmed death 1 (PD-1) antibody than Sema4A-negative NSCLC. Intriguingly,...
BackgroundNovel biomarkers (BMs) are urgently needed for bronchial asthma (BA) with various phenotypes and endotypes.ObjectiveWe sought to identify novel BMs reflecting tissue pathology from serum extracellular vesicles (EVs).MethodsWe performed data-independent acquisition of EVs 4 healthy controls, noneosinophilic (NEA) patients, eosinophilic (EA) patients BA. We confirmed EA-specific via validation in 61 BA 23 controls. To further validate these findings, we 6 chronic rhinosinusitis...
Immune checkpoint inhibitors (ICIs) are indicated for a diverse range of cancer types, and characterizing the tumor immune microenvironment is critical optimizing therapeutic strategies, including ICIs. T cell infiltration activation status in greatly affects efficacy Here, we show that semaphorin 6D (Sema6D) forward signaling, which reportedly involved coordinating orientation development migration as guidance factor, impaired tumor-specific CD8+ cells murine oral tumors. Sema6D expressed...
Progressive pulmonary fibrosis (PPF), defined as the worsening of various interstitial lung diseases (ILDs), currently lacks useful biomarkers. To identify novel biomarkers for early detection patients at risk PPF, we performed a proteomic analysis serum extracellular vesicles (EVs). Notably, identified candidate were enriched lung-derived proteins participating in fibrosis-related pathways. Among them, surfactant-associated protein B (SFTPB) EVs could predict ILD progression better than...
Type-A CpG oligodeoxynucleotides (ODNs), which have a natural phosphodiester backbone, is one of the highest IFN-α inducer from plasmacytoid dendritic cells (pDC) via Toll-like receptor 9 (TLR9)-dependent signaling. However, in vivo application has been limited because rapid degradation results relatively weak biological effect compared to other Type-B, -C, and -P ODNs, nuclease-resistant phosphorothioate backbones. To overcome this limitation, we developed lipid nanoparticles formulation...
Bronchoalveolar lavage is commonly performed to assess inflammation and identify responsible pathogens in lung diseases. Findings from bronchoalveolar might be used evaluate the immune profile of tumor microenvironment (TME). To investigate whether fluid (BALF) analysis can help patients with non-small cell cancer (NSCLC) who respond checkpoint inhibitors (ICIs), BALF blood were prospectively collected before initiating nivolumab. The secreted molecules, microbiome, cellular profiles based...
Background Concurrent KRAS LKB1 (STK11, KL) mutant non-small cell lung cancers (NSCLC) do not respond well to current immune checkpoint blockade therapies, however targeting major histocompatibility complex class I-related chain A or B (MICA/B), could pose an alternative therapeutic strategy through activation of natural killer (NK) cells. Methods Expression NK activating ligands in NSCLC line and patient data were analyzed. Cell surface expression MICA/B lines was determined flow cytometry...
Nontuberculous mycobacterial pulmonary disease (NTM-PD), mainly caused by Mycobacterium avium complex (MAC), and tuberculosis (TB) are emerging health problems worldwide. However, because their clinical features often similar, it remains difficult to differentiate NTM-PD from TB when the diagnosis cannot be made sputum culture. To investigate potential serum biomarkers, we conducted non-targeted proteome analysis on extracellular vesicles (EVs) collected 10 patients with MAC (MAC-PD), 7 TB,...
<title>Abstract</title> Background Hypereosinophilic syndrome is a group of disorders characterized by organ dysfunction caused hypereosinophilia, which frequently leads to thromboembolic complications with potentially fatal outcomes. Interleukin-5, key cytokine that promotes the differentiation and activation eosinophils, has been identified as therapeutic target. Anti-interleukin-5 antibody therapy demonstrated efficacy in reducing eosinophil counts enabling steroid dose tapering patients...
Abstract Background Interstitial lung disease (ILD), represented by idiopathic pulmonary fibrosis (IPF) and progressive (PPF), shows poor prognosis due to fibrosis. Early therapeutic intervention is required enhance the efficacy of antifibrotic drugs, highlighting importance early detection ILD progression. Although candidate biomarkers for predicting progression have been recently reported through omics analyses, clinically measurable remain unestablished. This study aimed identify that...
Red cells of the clam Barbatia reeveana express two hemoglobins, one composed 16- to 17-kDa chains and other 35-kDa chains. The nucleotide sequence cDNA encoding chain shows that polypeptide has very similar heme-binding domains, which are joined without use an additional bridging sequence. Two novel introns occur in gene for two-domain globin: one, "precoding" intron, is located bases 5' from start codon, other, a "bridge" separates DNA sequences domains. Close correspondence exists between...
Abstract Cancer immunotherapy has shown great promise as a new standard therapeutic strategy against cancer. However, the response rate and survival benefit remain unsatisfactory because most current approaches, such use of immune checkpoint inhibitors, depend on spontaneous antitumor responses. One possibility for improving efficacy is to promote immunity using adjuvants or specific cytokines actively. IL-33 been candidate cytokine therapies, but it remains unclear how in which situations...
Rationale: Most of nonsmall cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) activating mutations eventually acquire resistance to the first EGFR-tyrosine kinase inhibitors (TKIs) therapy after varying periods treatment. Of note, approximately one-third those develop brain metastases, which deteriorate their quality life and survival. The effect systemic chemotherapy on metastases acquisition EGFR-TKI is limited, thus far, whole-brain radiation therapy, may...
Granzyme B (GrB) is an essential cytotoxic effector in cancer immunotherapy as it can be a potential biomarker to predict the efficacy of immunotherapies including checkpoint inhibitors.Monitoring activity cells would help determine patient's clinical response treatment and lead better strategies by preventing administration ineffective therapies avoid adverse events resulting delay subsequent treatment.Methods: A microfluidic device with hydrodynamic traps pneumatic valving system was...
Abstract Sarcoidosis is a complex, polygenic, inflammatory granulomatous multi-organ disease of unknown cause. The inflammation in sarcoidosis driven by the interplay between T cells and macrophages. Extracellular vesicles (EVs) play important roles intercellular communication. We subjected serum EVs, isolated size exclusion chromatography, from seven patients with five control subjects to non-targeted proteomics analysis. Non-targeted, label-free analysis detected 2292 proteins EVs; 42 were...
Although small cell lung cancer (SCLC) is initially sensitive to chemotherapy, it recurs in most cases. Standard regimens for salvage chemotherapy have not been established, and the prognosis of relapsed SCLC remains poor. In present study, we investigated clinical efficacy safety nanoparticle albumin-bound paclitaxel (nab-paclitaxel) treatment SCLC. this retrospective multicenter analysis, 14 patients (3 women 11 men; median age 71 years) with received nab-paclitaxel alone or combination...
Group 2 innate lymphoid cells (ILC2s) have been implicated in both physiologic tissue remodeling and allergic pathology, yet the niche signaling required for ILC2 properties is poorly understood. Here, we show that an axonal guidance cue semaphorin 6D (Sema6D) plays critical roles maintenance of IL-10–producing ILC2s. Sema6d −/− mice exhibit a severe steady-state reduction ILC2s peripheral sites such as lung, visceral adipose tissue, mesentery. Interestingly, loss Sema6D results suppressed...