A5063991205- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Nutrition and Health in Aging
- Colorectal and Anal Carcinomas
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Brain Metastases and Treatment
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Telomeres, Telomerase, and Senescence
Kagoshima University
2015-2021
Columbia University Irving Medical Center
2019-2020
National Center on Addiction and Substance Abuse at Columbia University
2020
Health First
2020
University of Pennsylvania
2018-2019
Breast Center
2016
Fred Hutch Cancer Center
2016
University of Washington Medical Center
2016
Cancer Research Center
2016
John Wiley & Sons (United States)
2016
Abstract Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat among the deadliest human malignancies. We describe protocols initiate, grow, passage, characterize patient‐derived organoids (PDO) of esophageal cancers, as well carcinomas oral/head‐and‐neck anal origin. Formed rapidly (<14 days) from a single‐cell suspension embedded in basement membrane matrix, cancer PDO recapitulate histology original tumors....
Patients with advanced esophageal squamous cell carcinoma ( ESCC ) is received chemoradiotherapy or chemotherapy for clinical management. However, it difficult to predict tumor response and prognosis using blood markers before starting treatments. The purpose of this study was investigate the pre‐treatment plasma fibrinogen neutrophil–lymphocyte ratio NLR in patients treated chemotherapy, assess utility a combined score these markers, named as F‐ (fibrinogen score, predictor prognosis. A...
Abstract Stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. Although evidence exists in support positive role for cancer, its has remained somewhat controversial because insufficient study how genetic deletion may affect carcinogenesis various tissues. In this study, we show using epithelium-specific knockout mice (Stat3Δ/Δ) that blunts rather than supports antitumor immunity carcinogen-induced lung tumorigenesis. Stat3Δ/Δ did...
We assessed the clinical applicability of F-NLR score, which is based on fibrinogen (F) and neutrophil-lymphocyte ratio (NLR), Glasgow Prognostic Score (GPS) to predict therapeutic effects chemotherapy or chemoradiotherapy advanced gastric cancer prognoses patients.Sixty-eight patients with treated first-line were classified into two groups tumor response. Furthermore, we categorized according cutoff scores 2 [hyperfibrinogenemia (>400 mg/dl) high NLR (>3.0)], 1 [one these hematological...
The aim of the present study was to compare human epidermal growth factor receptor 2 (HER2) expression before and after trastuzumab-based chemotherapy in patients with advanced HER2-positive gastric cancer.We assessed HER2 using immunohistochemistry and/or fluorescence situ hybridization pre-treatment biopsied specimens post-treatment resected obtained from seven cancer receiving chemotherapy.Four maintained status three had a change positive negative. In showing loss treatments, tumor cells...
The homeostatic proliferation-differentiation gradient in the esophageal epithelium is perturbed under inflammatory disease conditions such as gastroesophageal reflux and eosinophilic esophagitis. Herein we describe protocols for rapid generation (<14 days) characterization of single-cell-derived, three-dimensional (3D) organoids from human subjects mice with normal mucosa or conditions. While 3D recapitulate epithelial renewal, proliferation, differentiation, non-cell autonomous reactive...
The mitochondria-to-nucleus retrograde signaling (MtRS) pathway aids in cellular adaptation to stress. We earlier reported that the Ca
The incidence of pathological lymph node metastases in patients with gastric cancer is 5% to 10%, which means that approximately 90% may undergo unnecessary lymphadenectomy. precise intraoperative diagnosis sentinel (SN) essential. purpose the current study was verify usefulness a rapid reverse transcriptase-polymerase chain reaction (RT-PCR) system compared hematoxylin and eosin staining for such diagnoses.A total 113 clinical T1-T2 (cT1-T2) cancer, including 73 cT1cN0 disease tumor...
Abstract Background Postoperative complications have been linked to the morbidity and mortality of several cancers. However, predicting whether will occur in early period after surgery or not is challenging. Hence, this study aimed examine diagnostic accuracy serum creatine phosphokinase (CPK) c-reactive protein (CRP) development postgastrectomy complications. Methods We retrospectively analyzed 188 patients with gastric cancer (GC) who underwent gastrectomy. The CPK CRP was investigated...
// Takaaki Arigami 1, 2, * , Yoshikazu Uenosono Shigehiro Yanagita 1 Keishi Okubo Takashi Kijima Daisuke Matsushita Masahiko Amatatsu Takahiko Hagihara Naoto Haraguchi Yuko Mataki Katsuhiko Ehi Sumiya Ishigami and Shoji Natsugoe 2 Department of Digestive Surgery, Breast Thyroid Kagoshima University Graduate School Medical Dental Sciences, Kagoshima, Japan Molecular Frontier These authors have contributed equally to this work Correspondence to: Arigami, email: arigami@m.kufm.kagoshima-u.ac.jp...
// Manti Guha 1 , 4 Satish Srinivasan Maura M. Sheehan Takashi Kijima Gordon Ruthel Kelly Whelan 2 Koji Tanaka Andres Klein-Szanto 3 Prasanna Chandramouleeswaran Hiroshi Nakagawa and Narayan G. Avadhani Department of Biomedical Sciences, School Veterinary Medicine, University Pennsylvania, Philadelphia, PA, USA Division Gastroenterology, Pennsylvania Perelman Histopathology Facility, Fox Chase Cancer Center, Temple University, Herbert Irving Comprehensive Columbia Medical New York, NY,...
The percentage of gastroduodenal neuroendocrine tumors (NETs) among all gastroenteropancreatic (GEP) NETs has gradually increased worldwide. Sentinel node navigation surgery (SNNS) been developed as a personalized approach in the surgical strategy for early gastrointestinal tract cancers. We herein report 2 cases treated with SNNS. Technetium-tin colloid including indocyanine green was endoscopically injected into submucosa around tumor day before surgery. Basin dissection sentinel nodes...
The clinical benefit of conversion surgery (CS) after chemotherapy remains unclear for stage IV gastric cancer (GC) patients. This study aimed to investigate the prognostic factors used determine whether CS is a promising therapeutic strategy.We retrospectively analyzed data from 156 patients diagnosed with unresectable GC who underwent as initial treatment, including 40 had R0 resection in CS.The median survival time was significant longer than that alone. A multivariate analysis identified...