A5100626875- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Stroke Rehabilitation and Recovery
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Cancer Cells and Metastasis
- Musculoskeletal pain and rehabilitation
- Gut microbiota and health
- Helicobacter pylori-related gastroenterology studies
- Bioinformatics and Genomic Networks
- DNA Repair Mechanisms
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cryospheric studies and observations
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Image Processing Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Clostridium difficile and Clostridium perfringens research
- Acute Ischemic Stroke Management
- Cancer-related Molecular Pathways
- Neurological Disease Mechanisms and Treatments
Institute of Biological Chemistry, Academia Sinica
2023-2025
Zhejiang Chinese Medical University
2023-2025
National Yang Ming Chiao Tung University
2010-2024
Wuhan University
2022-2024
Georgia State University
2020-2024
Chang Gung Memorial Hospital
2024
Soochow University
2011-2024
Soochow University
2024
VA Loma Linda Healthcare System
2024
China Medical University Hospital
2023
Abstract Background It is nearly impossible to overestimate the burden of chronic pain, which associated with enormous personal and socioeconomic costs. Chronic pain leading cause disability in world, multiple psychiatric comorbidities, has been causally linked opioid crisis. Access treatment called a fundamental human right by numerous organizations. The current COVID-19 pandemic strained medical resources, creating dilemma for physicians charged responsibility limit spread contagion treat...
The accumulation of extracellular β-amyloid (Aβ) plaques within the brain is unique to Alzheimer’s disease (AD) and thought induce synaptic deficits neuronal loss. Optimal therapies should tackle core AD pathophysiology prevent decline in memory cognitive functions. This study aimed evaluate therapeutic performance mesenchymal stem cell-derived exosomes (MSC-exosomes), which are secreted membranous elements encapsulating a variety MSC factors, on AD. A human neural cell culture model with...
Importance With the rising prevalence of mental disorders among children and adolescents, identifying modifiable associations is critical. Objective To examine association between physical fitness disorder risks. Design, Setting, Participants This nationwide cohort study used data from Taiwan National Student Fitness Tests Health Insurance Research Databases January 1, 2009 to December 31, 2019. were divided into 2 cohorts targeting anxiety depression (1 996 633 participants)...
Background. Most studies of bilateral arm training (BAT) did not employ a randomized controlled trial design and involved very limited functional tasks. Objective . Compare the effects BAT with control intervention (CI) on motor performance upper extremity also gains in patients chronic stroke. Methods. This 2-group pretreatment posttreatment measures enrolled 33 stroke (mean age = 53.85 years) 6 to 67 months after onset first They received either program concentrating both extremities...
Triple-negative breast cancer (TNBC), defined by the absence of an estrogen receptor, progesterone and human epidermal growth factor receptor 2 expression, is associated with early recurrence disease poor outcome. Furthermore, majority deaths in patients are from metastases instead primary tumors. In this study, MCF-7 (an receptor-positive cell line), MDA-MB-231 (a TNBC line) 4T1 mouse were used to investigate anti-cancer effects ionizing radiation (IR) combined suberoylanilide hydroxamic...
The traditional treatments for fibrosarcoma have limited efficacy. Therefore, new therapeutic strategies and/or adjuvant drugs still need to be explored. Accumulating evidence indicates that programmed cell death (PCD) is closely related anticancer therapy. Many studies shown tumor cells treated with experience the induction of type I PCD, apoptosis, and II autophagy. In present study, we investigated effects ionizing radiation (IR) combined arsenic trioxide (ATO) in human vitro xenograft...
Photochemically induced cerebral ischemia is an easy-manipulated, reproducible, relatively noninvasive, and lesion controllable model for translational study of ischemic stroke. In order to longitudinally investigate the characterization model, magnetic resonance imaging, 18F-2-deoxy-glucose positron emission tomography, fluorescence, bioluminescence imaging system were performed in correlation with triphenyl tetrazolium chloride (TTC), hematoxylin-eosin staining, immunohistochemistry...
Vibrio parahaemolyticus is a marine bacterium that can infect and cause the death of aquatic organisms. V . also human foodborne infection via contaminated seafood, with clinical syndromes which include diarrhea, abdominal cramps, nausea so on. Since controlling important for aquaculture health, various strategies have been explored. This study investigates application antagonistic microorganisms to inhibit growth We screened environment samples identified Bacillus subtilis strain O-741...
Breast Cancer (BC) is one of the most prevalent malignant tumors in women. The incidence estrogen receptor-positive (ER+) breast cancer as high 70%, and it increasing. Amorphophalli rhizoma (APR) has potential to be used cancer. objectives present study were explore impact different APR extracts on proliferation, migration, invasion ER+BC investigate their possible mechanism at molecular level. Various prepared solvents, such petroleum ether, ethyl acetate, n-butanol, water. ER+ T47D cell...
In this study, the role of phosphorylation in liquid–liquid phase separation (LLPS) tau, underlying driving forces, and potential implications on protein conformation subsequent aggregation were investigated. We compared vivo-produced phosphorylated tau (p-tau) nonphosphorylated under different coacervation conditions without adding crowding agents. Our findings revealed that spontaneous occurs exclusively p-tau, triggered by a temperature shift from 4 °C to room temperature, is driven...
Abstract Stat3 mediates a complex spectrum of cellular responses, including inflammation, cell proliferation, and apoptosis. Although evidence exists in support positive role for cancer, its has remained somewhat controversial because insufficient study how genetic deletion may affect carcinogenesis various tissues. In this study, we show using epithelium-specific knockout mice (Stat3Δ/Δ) that blunts rather than supports antitumor immunity carcinogen-induced lung tumorigenesis. Stat3Δ/Δ did...
Chiayi County is located in the largest alluvial plain of Taiwan with extensive aquaculture and rice farming sustained by water extracted from groundwater wells. a typical area affected land subsidence, yet such lands worldwide combine to provide nearly 90% global products, greatly reducing oceanic overfishing problems. This study uses precision leveling, multi-layer compaction monitoring well (MLCW) spaceborne SAR interferometry (InSAR) examine cause effect subsidence associated extractions...
Abstract To augment cytological diagnosis of pancreatic ductal adenocarcinoma (PDAC) in tissue samples obtained by minimally invasive endoscopic ultrasound‐guided fine needle aspiration, we investigated whether a small set molecular markers could accurately distinguish PDAC from chronic pancreatitis (CP). Expression levels 29 genes were first determined quantitative real‐time RT‐PCR training tissues which the final was ( n = 20) or CP 10). Using receiver operator characteristic curve...
Background Epigenetic variants have been shown in recent studies to be important contributors the pathogenesis of systemic lupus erythematosus (SLE). Here, we report a 2-step study discovery followed by replication identify DNA methylation alterations associated with SLE Chinese population. Using genome-wide microarray, Illumina Infinium HumanMethylation450 BeadChip, compared levels CpG sites extracted from white blood cells 12 female patients and 10 healthy controls. Results We identified...