A5081163727- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Electroconvulsive Therapy Studies
- Transcranial Magnetic Stimulation Studies
- Adenosine and Purinergic Signaling
- Schizophrenia research and treatment
- Substance Abuse Treatment and Outcomes
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Opioid Use Disorder Treatment
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrolyte and hormonal disorders
- Cannabis and Cannabinoid Research
- Neuropeptides and Animal Physiology
- Attention Deficit Hyperactivity Disorder
- Treatment of Major Depression
- Mental Health Research Topics
- Child and Adolescent Psychosocial and Emotional Development
- Mitochondrial Function and Pathology
National Cheng Kung University Hospital
2016-2025
Soochow University
2024
Soochow University
2018-2024
Quanta Computer (Taiwan)
2024
National Yang Ming Chiao Tung University
2010-2024
Chung Shan Medical University
2022
National Cheng Kung University
2011-2021
National Institute on Drug Abuse
2021
National Institutes of Health
2021
National Central University
2019-2021
Objective:Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines brain-derived neurotrophic factor between I, II, other specified disorder with short duration hypomania may support the association inflammatory dysregulation and, more specifically, provide for patients were similar to II from a marker perspective.
Vibrio parahaemolyticus is a marine bacterium that can infect and cause the death of aquatic organisms. V . also human foodborne infection via contaminated seafood, with clinical syndromes which include diarrhea, abdominal cramps, nausea so on. Since controlling important for aquaculture health, various strategies have been explored. This study investigates application antagonistic microorganisms to inhibit growth We screened environment samples identified Bacillus subtilis strain O-741...
Purpose As multinational firms seek to acquire competitive cost advantages through global sourcing, it is also important for them develop effective strategies reduce possible damage of a negative country‐of‐origin (COO) effect. This study aims examine whether brand image and evaluation mode could alleviate COO Design/methodology/approach A 2(COO)×2(brand)×2(evaluation mode) experimental design was employed in order effects on product vary under different modes. The data were analyzed by...
Objectives We aimed to examine whether the C-reactive protein (CRP) level could be used differentiate between major depressive disorder (MDD) and bipolar II (BD II). Methods Ninety-six healthy controls, 88 BD 72 MDD drug-naïve patients in their episodes were enrolled. The fasting plasma of high-sensitivity CRP was assessed at baseline after treatment. Results presented significantly higher 17-item Hamilton Depression Rating Scale (HDRS) scores levels when adjustment for age, gender, body...
Abstract The diagnosis of Bipolar II disorder (BD-II) is currently based on the patients’ description symptoms and clinical behavioral observations. This study explored possibility miRNA in peripheral blood (serum) as a specific biomarker for BD-II. We identified 6 candidate miRNAs to differentiate BD-II patients from controls using next-generation sequencing. then examined these real-time PCR first cohort (as training group) 79 95 controls. A diagnostic model was built tested an individual...
Abstract Background With the rising prevalence of mood disorders, there is a growing focus on distinguishing between Major Depressive Disorder (MDD) and Bipolar (BD), given their initial similarity in depressive episodes. Misdiagnosis can delay appropriate treatment1-3. Scholars collaborate to differentiate these disorders through neurocognitive, structural brain, clinical factors4,5. Aims This study posits that cognitive distinctions may be linked documented brain changes (e.g., prefrontal...
Abstract Background Emergent evidence showed that neuroinflammation may be involved in the pathogenesis of bipolar disorder (BD). Ouabain, a Na+/K+-ATPase inhibitor, is used to induce BD animal models [1] and associated with glial cell activation [2]. Our previous study ouabain treatment astrocytes increase matrix metalloproteinase (MMP)-8 expression. Aims & Objectives In present study, we investigated whether MMP-8 M8I, could control reduce manic-like behavior an ouabain-induced model....
Abstract Background Bipolar disorder (BD) is hypothesized to be associated with accelerated biological aging. Telomere length (TL) a biomarker of aging, and although TL reduces each cell division, the shortening rate may affected by allostatic load inflammation. We that BD patients have levels inflammatory markers TL. Aims & Objectives aimed investigate whether there in association between markers. Method healthy controls (HC) were recruited. The leukocyte plasma cytokines [tumor...
Abstract Objectives The primary objective of this study is to investigate the effects repetitive transcranial magnetic stimulation (rTMS) left dorsolateral prefrontal cortex (DLPFC) on symptom domains in mood disorders. Specifically, we endeavor characterize alterations symptoms and clarify if improvement concurrently associated with enhancements social cognition abilities individual cases. Methods Individuals diagnosed unipolar or bipolar depression participated a series 12 sessions 10 Hz...
Cheng-Tsung Lin, Tzu-Yun Wang, Tsung-Yu Tsai, Huai-Hsuan Tseng, Kao Chin Chen, I Hui Lee, Po See Yen Kuang Yang, Ru-Band Lu. Clin Psychopharmacol Neurosci -0001;0:. https://doi.org/10.9758/cpn.24.1248
Abstract Background and Hypothesis Minor physical abnormalities (MPAs) are neurodevelopmental markers that can be traced to prenatal events may significant features of early-onset schizophrenia (EOS). Therefore, our study aimed (1) find the primary interaction effects MPAs for EOS (2) develop validate model based on explainable machine learning algorithms. Study Design The included 549 patients with (193 356 AOS) 420 healthy controls (HC) in southern Taiwan. For feature selection, variable...
Much evidence supports the role of serotonin transporter (SERT) in pathophysiology and pharmacotherapy major depressive disorder (MDD) suicidal behaviors. In this study, we recruited 17 antidepressant-naïve patients with MDD age- gender-matched healthy controls. SERT availability was measured vivo N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) positron emission tomography (PET) imaging. The 21-item Hamilton Depression Rating Scale (HDRS) Beck for Suicide Ideation...
Abstract The aims of this study were to compare the quality life (QOL) between subjects with and without heroin use examine association QOL sociodemographic characteristics, characteristics use, family support, depression among users at entry a methadone maintenance treatment program. A group 123 who visited an outpatient addiction clinic in southern Taiwan for recruited into study. We also 106 had never used as control group. Their status was assessed by short form Version World Health...
Memantine, a noncompetitive N-methyl-d-aspartate receptor antagonist with mood-stabilizing effect, and an association between bipolar disorder proinflammatory cytokine levels have been reported. Whether adding-on memantine would reduce is more effective than valproic acid (VPA) alone in II was investigated. A randomized, double-blind, controlled, 12-week study conducted. Patients undergoing regular VPA treatments were randomly assigned to group: + (5 mg/d) (n = 106) or placebo 108). The...
Background: Repetitive transcranial magnetic stimulation (rTMS) shows potential therapeutic effects for individuals with addiction, but few studies have examined opioid use disorder (OUD).Objectives: We conducted an add-on double-blinded, sham-controlled rTMS feasibility pilot trial to examine OUD participants undergoing methadone maintenance therapy (MMT). The current report focused on the of (1) craving and heroin behavior (2) depression, impulsivity, attention.Methods: Active or sham...
Abstract We explored the effect of Brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism (rs6265) on correlation between changes in plasma levels with cognitive function and quality life (QoL) after 12 weeks treatment bipolar disorder (BD). Symptom severity were assessed upon recruitment during 1, 2, 4, 8 12. QoL, Wisconsin Card Sorting Test (WCST), Conners’ Continuous Performance (CPT) at baseline endpoint. The was genotyped. Changes QoL over reduced using analysis for evaluation...
Clozapine-associated fever is common but the specific cytokine changes and treatment durations that may cause remain unknown. We investigated association between inflammatory clozapine-induced in patients who were treated with clozapine.Forty-three schizophrenia or schizoaffective disorder, diagnosed by using Chinese Version of Mini International Neuropsychiatric Interview, clozapine for first time (first-time use group, n = 22) more than 6 months (long-term 21). The Positive Negative...