A5009796911- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Impact of Technology on Adolescents
- Electrolyte and hormonal disorders
- Substance Abuse Treatment and Outcomes
- Child and Adolescent Psychosocial and Emotional Development
- Child Development and Digital Technology
- Psychosomatic Disorders and Their Treatments
- Resilience and Mental Health
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Mental Health Research Topics
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
- Opioid Use Disorder Treatment
- Eating Disorders and Behaviors
- Digital Marketing and Social Media
- Functional Brain Connectivity Studies
- Nerve injury and regeneration
- Child Abuse and Trauma
- Behavioral Health and Interventions
- Obesity and Health Practices
- Cannabis and Cannabinoid Research
National Chung Hsing University
2021-2025
National Cheng Kung University
2014-2025
National Cheng Kung University Hospital
2014-2025
National Tsing Hua University
2025
China Medical University
2016-2022
China Medical University Hospital
2016-2022
National Taipei University
2022
University College London
2022
Asia University
2015-2021
National Kaohsiung University of Science and Technology
2021
Objective:Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines brain-derived neurotrophic factor between I, II, other specified disorder with short duration hypomania may support the association inflammatory dysregulation and, more specifically, provide for patients were similar to II from a marker perspective.
Abstract Psychosocial factors, including life satisfaction, resilience, and social support, have been proposed to influence depressive symptom severity in adults because the age of onset disorders, i.e. adolescence early adulthood, is associated with various impairments psychosocial functioning. In this study, a model was constructed verify these relationships prevent depression. For 370 participants were recruited from community via poster or online advertisements. They completed several...
Over the past two decades, smartphones have become common, and accompanying devices also much more popular easily accessible worldwide. With development of smartphones, accompanied by internet facilities, excessive smartphone use or addiction may cause sleep disturbance daily dysfunction. This study proposed examining association between personality traits its effects on disturbance. Four hundred twenty-two university participants (80 male 342 female participants) with a mean age 20.22 years...
Abstract Background and aims Individuals with schizophrenia may often experience poor sleep, self-stigma, impaired social functions, problematic smartphone use. However, the temporal relationships between these factors have not been investigated. The present study used a longitudinal design to examine potential mediating roles of sleep self-stigma in associations use functions among individuals schizophrenia. Methods From April 2019 August 2021, 193 (mean [SD] age = 41.34 [9.01] years; 88...
Abstract Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its immunosuppressive microenvironment and the immune privilege. Immunotherapy activating system T lymphocyte infiltration holds great promise against GBM. However, brain’s low immunogenicity difficulty of crossing blood-brain barrier (BBB) hinder therapeutic efficacy. Recent advancements in immune-actuated particles for targeted drug delivery have shown potential overcome these...
Abstract Background and aims There are limited data regarding associations between gaming disorder physical activity (PA). The present study investigated the direct association these two variables assessed potentially mediating roles of PA avoidance types weight stigma (i.e., internalized perceived stigma) in association. Methods An online cross-sectional survey that avoidance, stigma, level was completed late 2023 by 884 Taiwanese young adults aged 20 40 years (63.9% females). Multinomial...
Abstract Background Bipolar disorder (BD) is a debilitating and enduring mental condition characterized by consistent lifetime prevalence rates across different genders ethnic backgrounds. BD notorious for its high relapse erratic mood fluctuations, which can profoundly disrupt various facets of life. These disruptions extend to sleep patterns, interpersonal relationships, occupational functioning. Previous research has consistently highlighted impairments range neuropsychological social...
Abstract Background With the rising prevalence of mood disorders, there is a growing focus on distinguishing between Major Depressive Disorder (MDD) and Bipolar (BD), given their initial similarity in depressive episodes. Misdiagnosis can delay appropriate treatment1-3. Scholars collaborate to differentiate these disorders through neurocognitive, structural brain, clinical factors4,5. Aims This study posits that cognitive distinctions may be linked documented brain changes (e.g., prefrontal...
The surge in mobile gaming, fueled by smartphone and internet accessibility, lacks a comprehensive understanding of physiological changes during gameplay.
OBJECTIVES. Clarifying the association between bipolar I and II disorders at genetic level is essential for improving our understanding of them. In this study, we evaluated hypothesis that dopaminergic polymorphisms are risk factors disorders. We examined catechol-O-methyltransferase (COMT) Val158Met dopamine D3 receptor (DRD3) Ser9Gly disorders, as well possible interactions these genes. METHODS. Seven hundred eleven participants were recruited: 205 with I, 270 II, 236 healthy controls. The...
As prevail of mobile networking, social media became ubiquitous in either work or our personal life. Based on Media Synchronization Theory and transformational framework, this study proposed a research model examined how the media' attributes impacting effectiveness through work-oriented social-oriented usage. The data 322 valid questionnaires from respondents was analyzed by SmartPLS 3.2.8. results indicated that features including availability symbol variety had significant influences...
Preventative factors in young people's physical inactivity require further understanding, including related psychosocial (eg, body image and weight stigma). The Tendency to Avoid Physical Activity Sport Scale (TAPAS) is a recently developed instrument address this issue the present study examined its psychometric properties among Chinese university students particularly relation patterns across sex, activity (PA) level, status.Using convenience sample of 3142 (mean age = 19.8 years; 56%...
Clarifying the association between bipolar I and II, two most common subtypes of disorder, at genetic level is essential for improving our understanding these disorders. The dopaminergic system has been implicated in pathogenesis disorder. It may be important to investigate genes involved metabolizing dopamine encoding receptors, such as aldehyde dehydrogenase 2 (ALDH2) D2 receptor/ankyrin repeat kinase domain containing 1 (DRD2/ANKK1) genes. We examined ALDH2 DRD2/ANKK1 Taq IA polymorphisms...
ABSTRACT Previous studies on acetaldehyde dehydrogenase 2 ( ALDH2 ) focused drinking behavior or alcoholism because the ALDH 2* allele protects against risk of developing alcoholism. The mechanism provides that gene's protective effect is also involved in dopamine metabolism. interaction gene with neurotransmitters, such as dopamine, suggested to be related Because often co‐morbid antisocial personality disorder (ASPD), previous association cannot differentiate whether those genes relate...
Abstract Managing contradictions and building resilience help us overcome life's challenges. Here, we explored the link between attitudes towards psychological resilience, examining role of cortical conflict resolution networks. We enlisted 173 healthy young adults used questionnaires to evaluate their cognitive thinking styles resilience. They underwent structural functional magnetic resonance imaging scans. Our results revealed that contrasting toward contradictions, formal logic, naïve...
Abstract Background Several studies have hypothesized that genes regulating the components of serotonin system, including transporter ( 5-HTTLPR ) and 1 B receptor (5-HT1B), may be associated with alcoholism, but their results are contradictory because alcoholism’s heterogeneity. Therefore, we examined whether gene 5-HT1B G861C polymorphism susceptibility factors for a specific subtype antisocial alcoholism in Han Chinese Taiwan. Methods We recruited 273 male inmates personality disorder...