A5052566797- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural and Behavioral Psychology Studies
- Stress Responses and Cortisol
- Autism Spectrum Disorder Research
- Child and Adolescent Psychosocial and Emotional Development
- Electroconvulsive Therapy Studies
- Mental Health Research Topics
- Heart Rate Variability and Autonomic Control
- Genetics and Neurodevelopmental Disorders
- Attention Deficit Hyperactivity Disorder
- Substance Abuse Treatment and Outcomes
- Psychosomatic Disorders and Their Treatments
- Mental Health Treatment and Access
- Sexual function and dysfunction studies
- Mental Health and Psychiatry
- Opioid Use Disorder Treatment
- Family Caregiving in Mental Illness
- Cardiovascular Syncope and Autonomic Disorders
- Cannabis and Cannabinoid Research
National Cheng Kung University Hospital
2016-2025
National Cheng Kung University
2013-2024
Kaohsiung Veterans General Hospital
2016
Kaohsiung Medical University
2016
Kaohsiung Chang Gung Memorial Hospital
2016
National Yunlin University of Science and Technology
2016
National Science and Technology Council
2013-2016
Ministry of Education
2016
Atomic Energy Council
2016
Tainan University of Technology
2016
Objective:Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines brain-derived neurotrophic factor between I, II, other specified disorder with short duration hypomania may support the association inflammatory dysregulation and, more specifically, provide for patients were similar to II from a marker perspective.
Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study [ 99m Tc] TRODAT‐1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: Dopamine has been implicated the etiology of disorder. aim this was to explore transporter (DAT) availability patients. Methods: Seventeen drug‐free were recruited. DAT approximated using single...
Childhood trauma is associated with executive function impairment and an increased risk of methamphetamine (MA) use. MA use itself also compromises function. Limited evidence known about the association between childhood trauma, functioning treatment outcomes among individuals disorder (MAUD). The study explored whether patients MAUD who had experienced presented poorer outcomes. participants were all recruited from outpatient-based addiction clinic 2019 to 2022. was assessed using Trauma...
Inflammation is thought to be involved in the pathophysiology of bipolar disorder (BP) and metabolic syndrome. Prior studies evaluated association between profiles cytokines only during certain mood states instead their changes treatment. We enrolled drug-naïve patients with BP-II investigated correlation symptoms indices plasma cytokine levels after 12 weeks pharmacological Drug-naïve (n = 117) diagnosed according DSM-IV criteria were recruited. Metabolic (cholesterol, triglyceride, HbA1C,...
OBJECTIVES. Clarifying the association between bipolar I and II disorders at genetic level is essential for improving our understanding of them. In this study, we evaluated hypothesis that dopaminergic polymorphisms are risk factors disorders. We examined catechol-O-methyltransferase (COMT) Val158Met dopamine D3 receptor (DRD3) Ser9Gly disorders, as well possible interactions these genes. METHODS. Seven hundred eleven participants were recruited: 205 with I, 270 II, 236 healthy controls. The...
Abstract The Continuous Performance Test (CPT) is a widely used measure of sustained attention, which preferred tool for assessing various mental functions. A well‐established norm CPT essential when choosing suitable threshold classifying individuals as either case (CPT impairment) or non‐case. performance 900 adults who were randomly chosen from community survey was measured to establish the norms subgroups with different gender, age, and educational levels. results revealed that age level...
Objective. Although studies have indicated that the human basal ganglia a specific role in different memory systems, functional significance of striatal dopamine activities for remains less clear. This study assessed relationship between measures and indices systems healthy individuals. Method. Single photon emission computed tomography [ 123 I]IBZM (iodobenzamide) were used to assess D 2 /D 3 receptor density 62 volunteers aged 19 61 years. All subjects underwent Wechsler Memory Scale –...
Abstract We explored the effect of Brain-derived neurotrophic factor ( BDNF ) Val66Met polymorphism (rs6265) on correlation between changes in plasma levels with cognitive function and quality life (QoL) after 12 weeks treatment bipolar disorder (BD). Symptom severity were assessed upon recruitment during 1, 2, 4, 8 12. QoL, Wisconsin Card Sorting Test (WCST), Conners’ Continuous Performance (CPT) at baseline endpoint. The was genotyped. Changes QoL over reduced using analysis for evaluation...
Clozapine-associated fever is common but the specific cytokine changes and treatment durations that may cause remain unknown. We investigated association between inflammatory clozapine-induced in patients who were treated with clozapine.Forty-three schizophrenia or schizoaffective disorder, diagnosed by using Chinese Version of Mini International Neuropsychiatric Interview, clozapine for first time (first-time use group, n = 22) more than 6 months (long-term 21). The Positive Negative...
Top-down regulation in the human brain and anatomical connections between prefrontal cortex (PFC) specific catecholamine-related regions have been well-studied. However, way which PFC modulates downstream neuro-networks terms of serotonin autonomic nervous system (ANS) by variation level brain-derived neurotrophic factor (BDNF) is still unclear. We recruited sixty-seven healthy subjects. Serotonin transporter (SERT) availability was examined SPECT with [123I]ADAM analysis; heart rate...