A5049177021- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Genetics and Neurodevelopmental Disorders
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- Neurotransmitter Receptor Influence on Behavior
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Attention Deficit Hyperactivity Disorder
- Neuroinflammation and Neurodegeneration Mechanisms
- Child and Adolescent Psychosocial and Emotional Development
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Electroconvulsive Therapy Studies
- Family Caregiving in Mental Illness
- Obsessive-Compulsive Spectrum Disorders
- Electrolyte and hormonal disorders
- Diet and metabolism studies
- Regulation of Appetite and Obesity
- Maternal Mental Health During Pregnancy and Postpartum
- Transcranial Magnetic Stimulation Studies
National Cheng Kung University Hospital
2016-2025
National Cheng Kung University
2016-2025
Kaohsiung Medical University
2016-2022
National University of Tainan
2017
Tainan University of Technology
2016
Kaohsiung Veterans General Hospital
2016
Kaohsiung Chang Gung Memorial Hospital
2016
I-Shou University
2016
National Defense Medical Center
2016
National Science and Technology Council
2012-2016
Objective:Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines brain-derived neurotrophic factor between I, II, other specified disorder with short duration hypomania may support the association inflammatory dysregulation and, more specifically, provide for patients were similar to II from a marker perspective.
Abstract Objectives The primary objective of this study is to investigate the effects repetitive transcranial magnetic stimulation (rTMS) left dorsolateral prefrontal cortex (DLPFC) on symptom domains in mood disorders. Specifically, we endeavor characterize alterations symptoms and clarify if improvement concurrently associated with enhancements social cognition abilities individual cases. Methods Individuals diagnosed unipolar or bipolar depression participated a series 12 sessions 10 Hz...
Summary The inflammatory effects of glycogen synthase kinase‐3 (GSK‐3) have been identified; however, the potential mechanism is still controversial. In this study, we investigated GSK‐3‐mediated interleukin‐10 (IL‐10) inhibition on lipopolysaccharide (LPS)‐induced inflammation. Treatment with GSK‐3 inhibitor significantly blocked LPS‐induced nitric oxide (NO) production as well inducible NO (iNOS) expression in BV2 murine microglial cells and primary rat microglia‐enriched cultures. Using...
The amygdala is an important structure contributing to socio-emotional behavior. However, the role of in autism remains inconclusive. In this study, we used 28–35 days valproate (VPA)-induced rat model observe autistic phenotypes and evaluate their synaptic characteristics lateral nucleus (LA) amygdala. VPA-treated offspring demonstrated less social interaction, increased anxiety, enhanced fear learning impaired memory extinction. Slice preparation electrophysiological recordings showed...
Comorbidity exists between metabolic disorders and depressive syndrome with unclear mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet (HFD) to induce disorder phenotypes in mice. Initially, identified an enhanced glutamatergic input nucleus accumbens of HFD Retrograde tracing chemogenetic inhibition showed that hyperactive ventral hippocampal afferents determined exhibition depression-like behavior Using lentiviral knockdown overexpression approaches,...
Objectives We aimed to examine whether the C-reactive protein (CRP) level could be used differentiate between major depressive disorder (MDD) and bipolar II (BD II). Methods Ninety-six healthy controls, 88 BD 72 MDD drug-naïve patients in their episodes were enrolled. The fasting plasma of high-sensitivity CRP was assessed at baseline after treatment. Results presented significantly higher 17-item Hamilton Depression Rating Scale (HDRS) scores levels when adjustment for age, gender, body...
Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study [ 99m Tc] TRODAT‐1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation John Wiley & Sons A/S. Objectives: Dopamine has been implicated the etiology of disorder. aim this was to explore transporter (DAT) availability patients. Methods: Seventeen drug‐free were recruited. DAT approximated using single...
Accumulating evidence suggests that dysfunction of the amygdala is related to abnormal fear processing, anxiety, and social behaviors noted in autistic spectrum disorders (ASDs). In addition, studies have shown disrupted brain serotonin homeostasis linked ASD. With a valproate (VPA)-induced rat ASD model, we investigated possible role phenotypes further explored underlying mechanism. We first discovered distribution tryptophan hydroxylase immunoreactivity caudal raphe system was modulated on...
Abstract Peripheral injection with a high dose of valproic acid (VPA), histone deacetylase (HDAC) inhibitor, into animals mild or moderate spinal cord injury (SCI) for 1 week can reduce tissue loss and promote hindlimb locomotor recovery. A purinergic adenosine triphosphate (ATP) receptor subtype, P2X 4 (P2X R), has been considered as potential target to diminish SCI‐associated inflammatory responses. In this study, using minipump‐based infusion system, we found that intraspinal VPA 3 days...
Background: Cross-sectional studies have shown that late-onset depression is associated with larger deep white matter lesions (WMLs) and subcortical gray (GMLs). In a longitudinal analysis, we examined changes in WMLs GMLs older depressed nondepressed subjects over 4-year period.Methods: Brain magnetic resonance imaging (MRI) scans were obtained on 164 126 healthy aged 60 years or at baseline, 2 4 after recruitment. measured using semiautomated technique. We used repeated-measures analysis...
Endocannabinoids are critically involved in the extinction of fear memory. Here we examined effects repeated cannabinoid administration on memory rats and inhibitory synaptic transmission medial prefrontal cortex (mPFC) slices. Rats were treated with CB1 receptor agonist WIN55212-2 (WIN 10 mg/kg, i.p.) once per day for 7 d. On 8, submitted to a standard conditioning procedure, retention was measured potentiated startle paradigm. We found that (1) WIN-pretreated exhibited much less cue alone...