Abstract Background It is nearly impossible to overestimate the burden of chronic pain, which associated with enormous personal and socioeconomic costs. Chronic pain leading cause disability in world, multiple psychiatric comorbidities, has been causally linked opioid crisis. Access treatment called a fundamental human right by numerous organizations. The current COVID-19 pandemic strained medical resources, creating dilemma for physicians charged responsibility limit spread contagion treat...

Recurrent posterior instability of the shoulder can be difficult to diagnose and technically challenging treat. Although not as common anterior instability, recurrent is prevalent among certain demographic sporting groups, may overlooked if one aware typical examination radiographic findings. The diagnosis itself patients typically present with vague or confusing symptoms, treatment has evolved from open arthroscopic surgical techniques. This article intended review anatomy biomechanics...

Mobile-edge computing (MEC) has been regarded as a promising paradigm to reduce service latency for data processing in the Internet of Things (IoT) by provisioning resources at network edges. In this work, we jointly optimize task partitioning and computational power allocation computation offloading dynamic environment with multiple IoT devices edge servers. We formulate problem Markov decision process constrained hybrid action space, which cannot be well handled existing deep reinforcement...

Variations in Global Positioning Systems (GPSs) have been used for tracking users' locations. However, when location is needed an indoor space, such as a house or building, then alternative means of precise position may be required because GPS signals can severely attenuated completely blocked. In our approach to positioning, we developed localization system that minimizes the amount effort and cost by end user put use. This detects user's room-level within space which has installed. We...

Abstract The autonomous navigation of robots in unknown environments is a challenge since it needs the integration several subsystems to implement different functionality. It drawing map environment, robot localization, motion planning or path following, implementing real-world, and many others; all have be implemented simultaneously. Thus, development (ARN) problem essential for growth robotics field research. In this paper, we present simulation swarm intelligence method known as Particle...

Endoplasmic reticulum (ER) degradation pathways can selectively route proteins away from folding and maturation. Both soluble integral membrane be targeted the ER to proteasomal in this fashion. The cystic fibrosis transmembrane conductance regulator (CFTR) is an integral, multidomain protein localized apical surface of epithelial cells that functions facilitate Cl⁻transport. CFTR was among first for which a role proteasome ER-related described. However, signals ubiquitination...

We have developed a new strategy for the gene therapy of cancer based on activation purine nucleoside analogs by transduced E. coli phosphorylase (PNP, E.C. 2.4.2.1). The approach is designed to generate antimetabolites intracellularly that would be too toxic systemic administration. To determine whether this could used kill tumor cells without host toxicity, nude mice bearing human malignant D54MG glioma tumors expressing PNP (D54–PNP) were treated with either...

Abstract A deep‐learning neural network (DLNN) model was developed to predict thunderstorm occurrence within 400 km 2 South Texas domains for up 15 hr (±2 accuracy) in advance. The input features were chosen primarily from numerical weather prediction output parameters/variables; cloud‐to‐ground lightning served as the target. technique used stacked denoising autoencoder (SDAE) order create a higher representation of features. Logistic regression then applied SDAE train predictive model. An...

The reduction of visibility adversely affects land, marine, and air transportation. Thus, the ability to skillfully predict fog would provide utility. We categories below 1600 m, 3200 m 6400 by post-processing numerical weather prediction model output satellite-based sea surface temperature (SST) using a 3D-Convolutional Neural Network (3D-CNN). target is an airport located on barrier island adjacent major US port; measured from this serves as proxy for that develops over port. features...

Mapping and path planning in disaster scenarios is an area that has benefited from aerial imaging unmanned (UAV) surface vehicles (USV). Nowadays, there are many application areas of UAV USV which consist environmental monitoring, victim recovery river mapping the purpose rescue operations. There challenges for flood operations with existing systems where time response critical. The environment completely changing under conditions it causes a dangerous victims operators. Rescue boats widely...

Expression of <i>Escherichia coli</i> purine nucleoside phosphorylase (PNP) activates prodrugs and kills entire populations mammalian cells, even when as few 1% the cells express this gene. This phenomenon bystander killing has been previously investigated for herpes simplex virus-thymidine kinase (HSV-TK) shown to require cell contact. Using silicon rings separate <i>E. PNP expressing from non-expressing sharing same medium, we demonstrate that by does not cell-cell Initially, convert...

Abstract Invasion of exotic plants into vegetation communities on low‐nutrient soils in Sydney is often attributed to increased phosphorus the soil. However, composition native nearby national parks has been found be more closely correlated combinations soil nutrients and other environmental variables than alone. This study examined whether or a range better matched patterns urban bushland. Sites bushland were sampled, frequency recorded samples collected. Soil analysed for chemical physical...

We present a facial model designed primarily to support animated speech. Our takes geometry as input and transforms it into parametric deformable model. The uses muscle-based parameterization, allowing for easier integration between speech synchrony expressions. has highly lip that is grafted onto the provide necessary geometric complexity needed creating shapes high-quality renderings. also includes tongue can represent undergoes during add teeth, gums, upper palate complete inner mouth. To...

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The interaction of the ubiquitous Na(+)/H(+) exchanger, NHE1, with its commonly used inhibitors, amiloride- and benzoylguanidine (Hoechst type inhibitor (HOE))-type compounds, is incompletely understood. We previously cloned NHE1 from Amphiuma tridactylum (AtNHE1) Pleuronectes americanus (PaNHE1). Although highly homologous to HOE-sensitive human (hNHE1), AtNHE1 insensitive HOE-type PaNHE1 both compounds. Here we generated chimeras "knock in" amiloride HOE sensitivity PaNHE1, thereby...

Abstract The vegetation and sediment of urban non‐urban streams in the northern Sydney region were compared to examine possible effects urbanization on within‐stream vegetation. Many characteristics significantly different streams. At least one exotic plant species was found each stream sampled, but none presence led overall number abundance being higher Interestingly, native at sites same as sites, a suite usually present. This suggests that favour plants certain are adapted modified...

Seagrasses are critical components of marine food webs, yet negatively impacted by excessive coverage epiphyte (attached algae or plants) epifauna (organisms animals). Since nutrients result in epiphyte/epifauna growth, on seagrasses may serve as an indicator nutrient status local systems. In this work, the hyperspectral images obtained from seagrass samples investigated to quantify percent coverage. The N-FINDR algorithm is utilized for spectral analysis identify endmembers. Each test...

Abstract This paper presents the development of personalized job preparation and search training services for underrepresented STEM scholars as part an institutional partnership model created to assist dissertators, postdoctoral researchers, early career faculty along their path joining persisting in professoriate. work is a National Science Foundation (NSF) Alliances Graduate Education Professoriate (AGEP) grant awarded four university partners. The alliance goal develop, implement study...

The forecasting of hazardous atmospheric phenomena is often challenging. Artificial intelligence (AI) models have been applied to science problems. Model complexity provides a motivation quantify the importance model architecture components. We studied relative components FogNet that was designed for big data: 1) 3D versus 2D convolution, 2) physics-based grouping and ordering meteorological input features, 3) different auxiliary CNN-based feature learning modules 4) parallel sequential...

Recent innovations in 3D processing and availability of geospatial data have contributed largely to more comprehensive solutions visualization. As various formats are utilized describe the data, a combination layers from different sources allow us represent urban areas, contributing ideas emergency management smart cities. This work focuses on environment reconstruction using crowdsourced OpenStreetMap data. Once extracted, visualization pipeline draws features coloring for added context....