A5030178636- Congenital Heart Disease Studies
- Congenital heart defects research
- Lung Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Lung Cancer Treatments and Mutations
- Membrane Separation Technologies
- Pleural and Pulmonary Diseases
- Cardiovascular Issues in Pregnancy
- Neuroscience and Neuropharmacology Research
- Coronary Artery Anomalies
- Tracheal and airway disorders
- Kawasaki Disease and Coronary Complications
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Catalytic C–H Functionalization Methods
- Medical Imaging and Pathology Studies
- Sulfur-Based Synthesis Techniques
- Cardiac Valve Diseases and Treatments
- Cancer Diagnosis and Treatment
- Genomic variations and chromosomal abnormalities
- Occupational and environmental lung diseases
- Congenital Diaphragmatic Hernia Studies
- Gastric Cancer Management and Outcomes
- Cardiovascular Effects of Exercise
- Vascular Anomalies and Treatments
Tokyo Metropolitan Children's Medical Center
2020-2025
Keio University Hospital
2000-2024
Shinshu University
2020-2023
Keio University
2012-2023
Otemae Hospital
2017-2023
Osaka University
2003-2021
Faculty (United Kingdom)
2020
Engineering (Italy)
2020
Ōtani University
2020
Nagano University
2020
Haploinsufficiency of Tbx1 is likely a major determinant cardiac and craniofacial birth defects associated with DiGeorge syndrome. Although mice deficient in exhibit pharyngeal aortic arch defects, the developmental program mechanisms through which functions are relatively unknown. We identified single cis -element upstream that recognized winged helix/forkhead box (Fox)-containing transcription factors was essential for regulation endoderm head mesenchyme. The regulatory region responsive...
Birth defects, which occur in one out of 20 live births, often affect multiple organs that have common developmental origins. Human and mouse studies indicate haploinsufficiency the transcription factor TBX1 disrupts pharyngeal arch development, resulting cardiac craniofacial features associated with microdeletion 22q11 (del22q11), most frequent human deletion syndrome. Here, we generated an allelic series Tbx1 deficiency reveals a lower critical threshold for activity outflow tract compared...
The amino-acid balance in cancer patients often differs from that healthy individuals, because of metabolic changes. This study investigated the use plasma profiles as a novel marker for screening non-small-cell lung (NSCLC) patients.The concentrations venous blood samples pre-treatment NSCLC (n = 141), and age-matched, gender-matched, smoking status-matched controls 423), were measured using liquid chromatography mass spectrometry. resultant data set was subjected to multiple logistic...
Abstract Congenital heart defects (CHD) are very common in patients with trisomy 18 (T18) and 13 (T13). The surgical indication of CHD remains controversial since the natural history these trisomies is documented to be poor. To investigate outcome T18 T13, we collected evaluated clinical data from 134 27 T13 through nationwide network Japanese Society Pediatric Cardiology Cardiac Surgery. In T18, 23 (17%) were alive at this survey. One hundred twenty‐six (94%) had CHDs. most was ventricular...
Few studies with sufficient statistical power have shown the association of z score coronary arterial internal diameter events (CE) in patients Kawasaki disease (KD) artery aneurysms (CAA).To clarify time-dependent CE occurrence KD CAA.This multicenter, collaborative retrospective cohort study 44 participating institutions included 1006 younger than 19 years who received a angiography between 1992 and 2011.The CE, including thrombosis, stenosis, obstruction, acute ischemic events,...
Abstract Transcriptional regulation in a tissue‐specific and quantitative manner is essential for developmental events, including those involved cardiovascular morphogenesis. Tbx1 T‐box–containing transcription factor that responsible many of the defects observed 22q11 deletion syndrome humans. expressed secondary heart field (SHF) cardiac outflow tract (OFT) development. We previously reported regulated by sonic hedgehog means forkhead (Fox) factors head mesenchyme pharyngeal endoderm, but...
To investigate the effect of sucrose or caffeine ingestion on performance prolonged running, five male distance runners attending senior high school (15.6 yrs) carried out running a treadmill at an intensity corresponding to individuals' 80% V̇O2 max until exhaustion. Before and 45 min after exercise, subjects were given either placebo (Con), (81±18 g) (Su), (384±13 mg) (Caf), (72±22 plus (396±29 (Su + Caf) solution. The duration exercise was significantly longer in Su, Caf, Su Caf than Con....
Despite the report of new treatment options, surgery remains best for pulmonary metastases from renal cell carcinoma (RCC). Repeat resection is also an effective means recurrent metastases. The aim present study was to define prognostic factors survival after metastasectomy RCC based on a 25-year single-centre experience.Between 1973 and 2008, 59 thoracotomies 48 patients (38 men, 10 women) were performed in our hospital. resections eight patients. clinicopathological surgical data these...
Developing a PET ligand for imaging of the peripheral benzodiazepine receptor (PBR; Translocator Protein [18 kDa] TSPO) is great importance studying its role in glial cells injured brain and neurodegenerative disorders, such as Alzheimer9s disease. The aim this study was to synthesize evaluate <i>N</i>-benzyl-<i>N</i>-ethyl-2-(7-<sup>11</sup>C-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide (<sup>11</sup>C-AC-5216) PBR primate brain. <b>Methods:</b> AC-5216 desmethyl precursor...
Background Coronary arterial aneurysms (CAAs) associated with Kawasaki disease (KD) significantly affect prognosis. However, the clinical course of CAAs and factors CAA regression have not been well analyzed. Methods Results The cohort Z-Score 2nd Project Stage study, a multicenter, retrospective, study involving 44 institutions in Japan including 1006 patients KD, was examined. were classified by z score their internal diameter acute phase: small (z<5), medium (5≤z<10), large (z≥10). lower...
Chromosome 22q11.2 deletion causes DiGeorge syndrome, velocardiofacial conotruncal anomaly face syndrome with tetralogy of Fallot (TOF), and sporadic or familial TOF. To determine the prevalence clinical importance 22q 11.2 in TOF, a series 212 Japanese TOF patients was studied. The type pulmonary blood supply, which may lead to various outcomes, other additional anomalies were evaluated clinically. diagnosed by fluorescence situ hybridization N25 TUPLE1 probes. Of examined, 28 (13%) had...
We report on male monozygotic twins with 22q11.2 deletion and discordant phenotypes. The had twin-to-twin transfusion syndrome. Twin 1, the smaller of pair, Tetralogy Fallot, a characteristic facial appearance, swallowing dysfunction, anal atresia, short stature, mental retardation, whereas twin 2 appearance but no other signs 22q11 Fluorescence in situ hybridization analysis showed microdeletion chromosome both twins. Zygosity gave probability monozygosity greater than 99.999%. These...
This prospective study was undertaken to establish a novel management algorithm using new indicators decide the type of lung resection for small peripheral lesions.Inclusion criteria were: (1) <or=20mm lesion(s) and (2) absence significant lymph node swelling on preoperative CT. Along with conventional criteria, percentage ground-glass opacity (GGO) (>or=50% as GGO <50% solid type) high-resolution CT scan employed. In accordance such indicators, wide wedge (WWR), segmentectomy or lobectomy...